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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

提高CAR-T细胞疗法抗癌活性及安全性的研究进展

夏涌 黄健 钱其军

夏涌, 黄健, 钱其军. 提高CAR-T细胞疗法抗癌活性及安全性的研究进展[J]. 药学实践与服务, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
引用本文: 夏涌, 黄健, 钱其军. 提高CAR-T细胞疗法抗癌活性及安全性的研究进展[J]. 药学实践与服务, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
XIA Yong, HUANG Jian, QIAN Qijun. Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
Citation: XIA Yong, HUANG Jian, QIAN Qijun. Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023

提高CAR-T细胞疗法抗癌活性及安全性的研究进展

doi: 10.3969/j.issn.1006-0111.2016.04.023

Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy

  • 摘要: 经过25年的研究,以嵌合抗原受体(CAR)为基础的细胞治疗目前在治疗恶性肿瘤方面展现了巨大潜力。近几年有大量的相关试验和临床数据被报道,本综述通过对这些数据的对比和分析,讨论如何增强CAR-T细胞疗法对不可切除的恶性肿瘤的治疗效果,也对CAR-T细胞技术在恶性肿瘤临床治疗领域存在的安全问题及解决策略进行概述。
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    [16] Long AH, Haso WM, Shern JF, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors[J]. Nat Med,2015,21(6):581-590.
    [17] Song DG, Ye Q, Carpenito C, et al. In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137(4-1BB)[J]. Cancer Res,2011,71(13):4617-4627.
    [18] Zhao Z, Condomines M, van der Stegen SJ, et al. Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells[J]. Cancer Cell,2015,28(4):415-428.
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  • 收稿日期:  2016-01-06
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提高CAR-T细胞疗法抗癌活性及安全性的研究进展

doi: 10.3969/j.issn.1006-0111.2016.04.023

摘要: 经过25年的研究,以嵌合抗原受体(CAR)为基础的细胞治疗目前在治疗恶性肿瘤方面展现了巨大潜力。近几年有大量的相关试验和临床数据被报道,本综述通过对这些数据的对比和分析,讨论如何增强CAR-T细胞疗法对不可切除的恶性肿瘤的治疗效果,也对CAR-T细胞技术在恶性肿瘤临床治疗领域存在的安全问题及解决策略进行概述。

English Abstract

夏涌, 黄健, 钱其军. 提高CAR-T细胞疗法抗癌活性及安全性的研究进展[J]. 药学实践与服务, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
引用本文: 夏涌, 黄健, 钱其军. 提高CAR-T细胞疗法抗癌活性及安全性的研究进展[J]. 药学实践与服务, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
XIA Yong, HUANG Jian, QIAN Qijun. Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
Citation: XIA Yong, HUANG Jian, QIAN Qijun. Research progress on improving the anti-cancer activity and safety of the CAR-T cells therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
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