Experimental study on physical dependence of total Ervatamia yunnansis alkaloid
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摘要: 目的 评价狗牙花总生物碱的身体依赖性潜力。 方法 采用小鼠催促戒断和大鼠自然戒断模型对狗牙花总生物碱进行身体依赖性实验。 结果 在小鼠催促实验中，给予狗牙花总生物碱低剂量（140 mg/kg）、高剂量（430 mg/kg），连续注射7 d，而后经纳洛酮激发，实验小鼠未出现明显的戒断症状、跳跃次数增加和体重下降现象。在大鼠自然戒断实验中，给予狗牙花总生物碱低剂量（210 mg/kg）、高剂量（775 mg/kg），连续注射30 d，停药后未见大鼠出现戒断反应和体重下降现象。 结论 狗牙花总生物碱无身体依赖性。Abstract: Objective To evaluate the physical dependence of total Ervatamia yunnansis alkaloid. Methods The physical dependence of total Ervatamia yunnansis alkaloid was observed by jump test in mice and spontaneous withdrawal test in rats. Results In the jump test, after injecting total Ervatamia yunnansis alkaloid (total dosage of 140 and 430 mg/kg) for 7 days continuously, the mice didn't show any withdrawal symptom and the loss of body weight. In the spontaneous withdrawal test, two dosages of total Ervatamia yunnansis alkaloid (total dosage of 210 and 775 mg/kg) were continuously given for 30 days. The withdrawal response and the loss of body weight were not found in rats after drug withdrawal. Conclusion Total Ervatamia yunnansis alkaloid showed no obvious withdrawal symptoms in mice and rats, which suggests that it has no physical dependence.
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Key words:
- total Ervatamia yunnansis alkaloid /
- physical dependence /
- morphine
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[1] Brown TK. Ibogaine in the treatment of substance dependence[J]. Curr Drug Abuse Rev, 2013, 6(1):3-16. [2] Popik P, Layer RT, Skolnick P. 100 years of ibogaine:neurochemical and pharmacological actions of a putative anti-addictive drug[J]. Pharmacol Rev, 1995,47(2):235-237. [3] 国家中医药管理局中华本草编委会. 中华本草[M]. 17卷. 上海:上海科学技术出版社, 1999:5604. [4] 宣伟东,陈海生,袁志,等.云南狗牙花吲哚类生物碱成分及其生物活性研究[J].第二军医大学学报,2006,27(1):92-96. [5] 黄矛,周丽华,张晓冬,等. 狗牙花总碱防治吗啡依赖的药理作用[J]. 中国药物依赖性杂志, 2001, 10(1):8-10. [6] 陈梅玉, 周丽华,张晓冬,等.云南狗牙花总碱的镇痛作用[J]. 药学实践杂志, 2006, 24(4):203-205. [7] 傅秋生,鲍燕燕,衣淑珍,等.云南狗牙花总碱对吗啡依赖小鼠位置偏爱再现的阻断作用[J].解放军药学学报, 2004, 20(5):352-355. [8] Tang BQ, Wang WJ, Huang XJ, et al. Iboga-type Alkaloids from Ervatamia officinalis.[J]. J Nat Prod, 2014, 77(8):1839-1846. [9] Koenig X, Hilber K. The anti-addiction drug ibogaine and the heart:a delicate relation[J]. Molecules, 2015, 20(2):2208-2228. [10] Geng CA,Liu XK.Five new indole alkaloids from the leaves of Rauvolfia yunnanensis[J].Fitoterapia,2013,89(7):42-47. [11] 冯燕云,胡银婷,吴广勇,等. 细叶榕树提取物急性毒性及身体依赖性实验研究[J]. 右江民族医学院学报, 2014, 36(4):535-536. [12] 崔跃,李欣欣,崔皓哲,等.戒断对吗啡成瘾大鼠活动性的影响研究[J]. 中国现代药物应用, 2015, 9(16):264-265. [13] 国家食品药品监督管理局. 药物非临床依赖性研究技术指导原则2007版[S]. 北京:中国医药科技出版社,2007:6-11. [14] Bulling S, Schicker K, Zhang YW, et al. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters[J]. J Biol Chem, 2012, 287(22):18524-18534. -
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