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孤儿核受体NR4A1与动脉粥样硬化的研究进展

干润 霍炎 黄金路 杨全军 郭澄

干润, 霍炎, 黄金路, 杨全军, 郭澄. 孤儿核受体NR4A1与动脉粥样硬化的研究进展[J]. 药学实践与服务, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
引用本文: 干润, 霍炎, 黄金路, 杨全军, 郭澄. 孤儿核受体NR4A1与动脉粥样硬化的研究进展[J]. 药学实践与服务, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
GAN Run, HUO Yan, HUANG Jinlu, YANG Quanjun, GUO Cheng. Research progress on orphan nuclear receptor NR4A1 in atherosclerosis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
Citation: GAN Run, HUO Yan, HUANG Jinlu, YANG Quanjun, GUO Cheng. Research progress on orphan nuclear receptor NR4A1 in atherosclerosis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002

孤儿核受体NR4A1与动脉粥样硬化的研究进展

doi: 10.3969/j.issn.1006-0111.2016.04.002
基金项目: 国家自然科学基金(81503155);上海市科委基金(14ZR1432200);上海交通大学医工交叉项目(YG2014MS21)

Research progress on orphan nuclear receptor NR4A1 in atherosclerosis

  • 摘要: 孤儿核受体NR4A1是尚未发现特异性配体的转录因子之一,属于NR4A亚家族。早期研究发现,NR4A1可通过改变基因表达、翻译后修饰以及辅调蛋白间相互作用,调控细胞的增殖、凋亡、分化和应激反应。近年来研究发现其在动脉粥样硬化损伤部位表达异常,被认为是血管细胞功能紊乱过程中的关键调节基因。通过调控NR4A1基因的表达,可对平滑肌细胞的增殖和内皮细胞的激活产生重要影响,同时能够减少炎症反应、减少泡沫细胞的形成以及脂质沉积,抑制血管重塑,预防和阻止动脉粥样硬化的发生与发展。这些研究显示NR4A1可能成为研发预防和治疗动脉粥样硬化药物的新靶点。
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    [14] Cui M, Cai Z, Chu S, et al. Orphan nuclear receptor Nur77 inhibits angiotensin Ⅱ-induced vascular remodeling via downregulation of β-catenin[J]. Hypertension, 2016, 67(1):153-162.
    [15] Yu Y, Cai Z, Cui M, et al. The orphan nuclear receptor Nur77 inhibits low shear stress-induced carotid artery remodeling in mice[J]. Int J Mol Med, 2015, 36(6):1547-1555.
    [16] Bonta PI, van Tiel CM, Vos M, et al. Nuclear orphan receptors Nur77, Nurr1 and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses[J]. Arterioscler Thromb Vasc Biol, 2006, 26(10):2288-2294.
    [17] Pei L, Castrillo A, Chen M, et al. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli[J]. J Biol Chem, 2005, 280(32):29256-29262.
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孤儿核受体NR4A1与动脉粥样硬化的研究进展

doi: 10.3969/j.issn.1006-0111.2016.04.002
    基金项目:  国家自然科学基金(81503155);上海市科委基金(14ZR1432200);上海交通大学医工交叉项目(YG2014MS21)

摘要: 孤儿核受体NR4A1是尚未发现特异性配体的转录因子之一,属于NR4A亚家族。早期研究发现,NR4A1可通过改变基因表达、翻译后修饰以及辅调蛋白间相互作用,调控细胞的增殖、凋亡、分化和应激反应。近年来研究发现其在动脉粥样硬化损伤部位表达异常,被认为是血管细胞功能紊乱过程中的关键调节基因。通过调控NR4A1基因的表达,可对平滑肌细胞的增殖和内皮细胞的激活产生重要影响,同时能够减少炎症反应、减少泡沫细胞的形成以及脂质沉积,抑制血管重塑,预防和阻止动脉粥样硬化的发生与发展。这些研究显示NR4A1可能成为研发预防和治疗动脉粥样硬化药物的新靶点。

English Abstract

干润, 霍炎, 黄金路, 杨全军, 郭澄. 孤儿核受体NR4A1与动脉粥样硬化的研究进展[J]. 药学实践与服务, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
引用本文: 干润, 霍炎, 黄金路, 杨全军, 郭澄. 孤儿核受体NR4A1与动脉粥样硬化的研究进展[J]. 药学实践与服务, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
GAN Run, HUO Yan, HUANG Jinlu, YANG Quanjun, GUO Cheng. Research progress on orphan nuclear receptor NR4A1 in atherosclerosis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
Citation: GAN Run, HUO Yan, HUANG Jinlu, YANG Quanjun, GUO Cheng. Research progress on orphan nuclear receptor NR4A1 in atherosclerosis[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 292-296. doi: 10.3969/j.issn.1006-0111.2016.04.002
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