留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

心肌缺血的昼夜节律性与时辰疗法

张恩晖 王海峰 陈莉 刘佃花 于剑光 蔡国君

张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003

Circadian rhythms of myocardial ischemia and chronotherapy

  • 摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。
  • [1] Portaluppi F,Manfredini R,Fersini C.From a static to a dynamic concept of risk:the circadian epidemiology of cardiovascular events[J].Chronobiol Int,1999,16(1):33-49.
    [2] Haus E,Sackett-Lundeen L,Smolensky MH.Rheumatoid arthritis:circadian rhythms in disease activity,signs and symptoms,and rationale for chronotherapy with corticosteroids and other medications[J].Bull NYU Hosp Jt Dis,2012,70(Suppl 1):3-10.
    [3] Mori H,Nakamura N,Tamura N,et al.Circadian variation of basal total vascular tone and chronotherapy in patients with vasospastic angina pectoris[J].Biomed Pharmacother,2002,56(Suppl 2):339s-344s.
    [4] Thome C,Vajkoczy P,Horn P,et al.Continuous monitoring of regional cerebral blood flow during temporary arterial occlusion in aneurysm surgery[J].J Neurosurg,2001,95(3):402-411.
    [5] Araki H,Koiwaya Y,Nakagaki O,et al.Diurnal distribution of ST-segment elevation and related arrhythmias in patients with variant angina:a study by ambulatory ECG monitoring[J].Circulation,1983,67(5):995-1000.
    [6] Joy M,Pollard CM,Nunan TO.Diurnal variation in exercise responses in angina pectoris[J].Br Heart J,1982,48(2):156-160.
    [7] Ogawa H,Yasue H,Oshima S,et al.Circadian variation of plasma fibrinopeptide A level in patients with variant angina[J].Circulation,1989,80(6):1617-1626.
    [8] Kusama Y,Kodani E,Nakagomi A,et al.Variant angina and coronary artery spasm:the clinical spectrum, pathophysiology,and management[J].J Nippon Med Sch, 2011,78(1):4-12.
    [9] Edahiro R,Sakata Y,Nakatani D,et al.Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction:a prospective observational study in Japan[J].BMJ Open,2014,4(6):e005067.
    [10] Selvi Y,Smolensky MH,Boysan M,et al.Role of patient chronotype on circadian pattern of myocardial infarction:a pilot study[J].Chronobiol Int,2011,28(4):371-377.
    [11] Behar S,Halabi M,Reicher-Reiss H,et al.Circadian variation and possible external triggers of onset of myocardial infarction.SPRINT Study Group[J].Am J Med,1993,94(4):395-400.
    [12] Gilpin EA,Hjalmarson A,Ross JJr.Subgroups of patients with atypical circadian patterns of symptom onset in acute myocardial infarction[J].Am J Cardiol,1990,66(16):7G-11G.
    [13] Hjalmarson A,Gilpin EA,Nicod P,et al.Differing circadian patterns of symptom onset in subgroups of patients with acute myocardial infarction[J].Circulation,1989,80(2):267-275.
    [14] Kanth R,Ittaman S,Rezkalla S.Circadian patterns of ST elevation myocardial infarction in the new millennium[J].Clin Med Res,2013,11(2):66-72.
    [15] Kinjo K,Sato H,Sato H,et al.Circadian variation of the onset of acute myocardial infarction in the Osaka area,1998-1999:characterization of morning and nighttime peaks[J].Jpn Circ J,2001,65(7):617-620.
    [16] Trappolini M,Matteoli S,Borgia MC,et al.Circadian variations in the onset of acute myocardial infarction[J]. Minerva Cardioangiol,2001,49(5):289-296.
    [17] Cohen MC,Rohtla KM,Lavery CE,et al.Meta-analysis of the morning excess of acute myocardial infarction and sudden cardiac death[J].Am J Cardiol,1997,79(11):1512-1516.
    [18] Arntz HR,Willich SN,Oeff M,et al.Circadian variation of sudden cardiac death reflects age-related variability in ventricular fibrillation[J].Circulation,1993,88(5 Pt 1):2284-2289.
    [19] Willich SN,Goldberg RJ,Maclure M,et al.Increased onset of sudden cardiac death in the first three hours after awakening[J].Am J Cardiol,1992,70(1):65-68.
    [20] Hansen O,Johansson BW,Gullberg B.The clinical outcome of acute myocardial infarction is related to the circadian rhythm of myocardial infarction onset[J].Angiology,1993,44(7):509-516.
    [21] Fujita M,Araie E,Yamanishi K,et al.Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction[J].Am J Cardiol,1993,71(15):1369-1371.
    [22] Cooke-Ariel H.Circadian variations in cardiovascular function and their relation to the occurrence and timing of cardiac events[J].Am J Health Syst Pharm,1998,55(Suppl 3):5-11.
    [23] Furlan R,Guzzetti S,Crivellaro W,et al.Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects[J].Circulation,1990,81(2):537-547.
    [24] Yasue H,Touyama M,Kato H,et al.Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm:documentation by coronary arteriography[J].Am Heart J,1976,91(2):148-155.
    [25] Wolk R,Gami AS,Garcia-Touchard A,et al.Sleep and cardiovascular disease[J].Curr Probl Cardiol,2005,30(12):625-662.
    [26] Hilfenhaus M.Circadian rhythm of the renin-angiotensin-aldosterone system in the rat[J].Arch Toxicol,1976,36(3-4):305-316.
    [27] Cugini P,Lucia P.Circadian rhythm of the renin-angiotensin-aldosterone system:a summary of our research studies[J].ClinTer,2004,155(7-8):287-291.
    [28] Vaughan DE,Lazos SA,Tong K.Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells.A potential link between the renin-angiotensin system and thrombosis[J].J Clin Invest,1995,95(3):995-1001.
    [29] Brown NJ,Kim KS,Chen YQ,et al.Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production[J].J Clin Endocrinol Metab,2000,85(1):336-344.
    [30] Clow A,Hucklebridge F,Stalder T,et al.The cortisol awakening response:more than a measure of HPA axis function[J].Neurosci Biobehav Rev,2010,35(1):97-103.
    [31] Wilhelm I,Born J,Kudielka BM,et al.Is the cortisol awakening rise a response to awakening?[J].Psychoneuroendocrinology,2007,32(4):358-366.
    [32] Champaneri S,Xu X,Carnethon MR,et al.Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus:the Multi-Ethnic Study of Atherosclerosis[J].Metabolism,2012,61(7):986-995.
    [33] Sahna E,Parlakpinar H,Turkoz Y,et al.Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes[J].Physiol Res,2005,54(5):491-495.
    [34] Buxton OM,L'Hermite-Balériaux M,Turek FW,et al.Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion[J].Am J Physiol Regul Integr Comp Physiol,2000,278(2):373-382.
    [35] Ludka O,Spinar J,Pozdisek Z,et al.Is there circadian variation of big endothelin and NT-proBNP in patients with severe congestive heart failure?[J]. Vnitr Lek,2010,56(6):488-493.
    [36] Tofler GH,Brezinski D,Schafer AI,et al.Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death[J].N Engl J Med,1987,316(24):1514-1518.
    [37] Quyyumi AA,Crake T,Wright CM,et al.Medical treatment of patients with severe exertional and rest angina:double blind comparison of beta blocker,calcium antagonist,and nitrate[J].Br Heart J,1987,57(6):505-511.
    [38] Conte G,Rigon N,Perrone A.Application of chronotherapy to cardiovascular diseases [J].Recenti Prog Med,1998,89(9):465-469.
    [39] Kuwajima I,Abe K.Effects of the long-acting calcium channel blocker barnidipine hydrochloride on 24-h ambulatory blood pressure[J].Blood Press Monit,2002,7(1):63-65.
  • [1] 伊博文, 刘慧宁, 郑蕊, 任佳伟, 刘洋.  荜茇提取物中5个生物碱的含量测定与对垂体后叶素所致大鼠实验性心肌缺血的影响 . 药学实践与服务, 2023, 41(4): 218-221, 264. doi: 10.12206/j.issn.2097-2024.202112011
    [2] 伊博文, 刘慧宁, 郑蕊, 任佳伟, 刘洋.  荜茇提取物中5个生物碱的含量测定与对垂体后叶素所致大鼠实验性心肌缺血的影响 . 药学实践与服务, 2023, 41(6): 1-5. doi: 10.12206/j.issn.2097-2024.202112011
    [3] 刘玉兰, 刘梅, 鲁毅, 毕慧, 许桂丽.  1例急性心肌梗死合并三尖瓣修补术患者的抗栓治疗及药学监护 . 药学实践与服务, 2023, 41(12): 760-762. doi: 10.12206/j.issn.2097-2024.202204122
    [4] 管文婕, 陈慧慧, 汪涛, 张晨晨, 陈延杰, 朱捷.  冠状动脉介入术后发生肝素诱导的血小板减少症抗栓治疗的药学监护 . 药学实践与服务, 2019, 37(4): 370-374. doi: 10.3969/j.issn.1006-0111.2019.04.017
    [5] 杨贤, 郑萍.  临床药师参与1例亚急性心肌梗死合并腔隙性脑梗及深静脉血栓患者的抗栓治疗体会 . 药学实践与服务, 2017, 35(2): 161-164. doi: 10.3969/j.issn.1006-0111.2017.02.016
    [6] 姜舒, 芮耀诚, 李铁军.  心肌梗死中涉及炎症和凋亡的机制 . 药学实践与服务, 2016, 34(2): 119-123. doi: 10.3969/j.issn.1006-0111.2016.02.007
    [7] 高越, 陈安妮, 赵亚红, 薛丹, 安泳潼, 柴逸峰, 张海.  养心氏片防治慢性缺血性心力衰竭及急性心肌缺血再灌注损伤的实验研究 . 药学实践与服务, 2016, 34(5): 403-407,415. doi: 10.3969/j.issn.1006-0111.2016.05.006
    [8] 田霖, 郭海霞, 张洁, 焦育强, 吴秋业, 张川.  新型丹参素衍生物的合成与抗心肌缺血活性研究 . 药学实践与服务, 2015, 33(6): 525-528,535. doi: 10.3969/j.issn.1006-0111.2015.06.012
    [9] 程晶晶, 刘谋治, 李洪娇, 阎澜, 姜远英, 颜天华.  新化合物TG6对心肌缺血/再灌注损伤的影响及机制研究 . 药学实践与服务, 2014, 32(6): 440-443. doi: 10.3969/j.issn.1006-0111.2014.06.010
    [10] 唐庆年, 伍倩, 田淑娟, 毛峻琴.  黄杞叶和片姜黄提取物及其组方对大鼠急性心肌缺血的保护和协同作用 . 药学实践与服务, 2013, 31(2): 120-123. doi: 10.3969/j.issn.1006-0111.2013.02.010
    [11] 李洪斌, 于泓, 杨世杰.  益心酮抗心肌缺血作用的实验研究 . 药学实践与服务, 2011, 29(3): 188-192.
    [12] 陆文铨, 张国强, 陈大贵, 张川.  丹参素对大鼠急性心肌缺血的保护作用 . 药学实践与服务, 2010, 28(4): 279-282.
    [13] 于大海.  刺五加总皂苷对大鼠心肌缺血性再灌注的保护作用及机制研究 . 药学实践与服务, 2008, (3): 197-199,232.
    [14] 许文雅, 郭炜, 顾晓慧, 杨新鹏, 章忱, 吕嵘, 卫洪昌.  益心口服液预处理对大鼠急性心肌缺血的保护作用 . 药学实践与服务, 2008, (6): 422-426.
    [15] 卫洪昌, 王秀薇, 吕嵘, 程金波, 朱晓梅, 吴倩, 章忱.  益心口服液药物预处理对大鼠心肌缺血再灌注损伤的影响 . 药学实践与服务, 2001, (3): 157-159.
    [16] 李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸.  黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响 . 药学实践与服务, 2001, (5): 270-272.
    [17] 孙平龙, 朱晓梅, 卫洪昌.  徐长卿内关穴位注射对大鼠心肌缺血再灌注损伤的影响 . 药学实践与服务, 2000, (4): 212-215.
    [18] 卫洪昌, 朱冬胜, 朱晓梅, 孙平龙, 戴薇薇.  益心口服液预处理对急性心肌缺血大鼠CEC、血浆ET、CGRP及心肌病理形态学的影响 . 药学实践与服务, 1999, (4): 202-204.
    [19] 刘卫, 郭卫, 张黎明, 赵志春, 苏定冯.  硝苯地平缓释片对高血压昼夜节律的作用 . 药学实践与服务, 1998, (5): 261-262.
    [20] 陶学斌, 李万亥.  钙超载与心肌缺血再灌注损伤 . 药学实践与服务, 1993, (4): 242-244.
  • 加载中
计量
  • 文章访问数:  2717
  • HTML全文浏览量:  320
  • PDF下载量:  124
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-09-19
  • 修回日期:  2015-04-28

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003

摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。

English Abstract

张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
参考文献 (39)

目录

    /

    返回文章
    返回