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乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析

杨喜晶 周福平 张迁 钱其军

杨喜晶, 周福平, 张迁, 钱其军. 乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析[J]. 药学实践与服务, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
引用本文: 杨喜晶, 周福平, 张迁, 钱其军. 乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析[J]. 药学实践与服务, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
Citation: YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019

乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析

doi: 10.3969/j.issn.1006-0111.2015.04.019

Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome

  • 摘要: 目的 探讨乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤(SPTCL)伴噬血细胞综合征(HPS)的临床特征和治疗方法。 方法 回顾性分析2014年8月第二军医大学附属东方肝胆外科医院1例乙肝肝硬化并发SPTCL伴HPS病例的临床资料。 结果 T细胞受体(TCR)表型不同则该病的侵袭性、治疗反应性及预后明显不同,伴HPS者治疗效果不佳,生存期短。 结论 乙肝肝硬化并发SPTCL伴HPS罕见,早期骨髓形态学、病理学、免疫组化及基因重排检测对确诊有重要意义,及早有效控制乙肝病毒尤为重要。早期诊断及治疗对延长患者生存期有重要意义。
  • [1] Gonzalez CL, Medeiros LJ, Braziel RM, et al.T-cell lymphoma involving subcutaneous tissue A clinicopathologic entity commonly associated with hemophagocytic syndrome[J]. Am J Surg Pathol,l991,15:17-27.
    [2] Go RS, Wester SM.Immunophenotypic and molecular features, clinical outcomes, treatments and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma: a systematic analysis of 156 patients reported in the literature[J].Cancer, 2004,l01(6):1404-1413.
    [3] Takeshita M,Okamura S,Oshiro Y, et al.Clinicopathologic differences between 22 cases of CD56-negative and CD56-positive subcutaneous panniculitis-like lymphoma in Japan[J].Hum Pathol,2004,35(2):231-239.
    [4] 马 兰,柴俊月,郑雯琦,等继发于淋巴瘤的嗜血细胞综合征6例临床分析[J].世界最新医学信息文摘,2014,14(2):96.
    [5] Huang JJ, Cai MY, Ye S,et al. Clinical analysis of 19 cases of subcutaneous panniculitis T-cell lymphoma with literature review[J]. Ai Zheng,2009,28 (10): 1093-1099.
    [6] Briki H,Bouaziz J D,Molinier-Frenkel V, et al.Subcutaneous panniculitis-like T-cell lymphoma αβ:complete sustained remission with corticosteroids and methotrexate[J].Br J Dermatol, 2010,163(5):1136-1138.
    [7] Guenova E, Schanz S, Hoetzenecker W, et al. Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma[J]. Br J Dermatol,2014,171 (4): 891-894.
    [8] Sakurai E, Satoh T, Akiko YA, et al. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation[J]. J Clin Exp Hematop, 2013,53 (2): 135-140.
    [9] Chen R, Liu L,Liang YM,et al. Treatment relapsed subcutaneous panniculitis-like T-cell lymphoma together HPS by cyclosporin A[J]. Hematol Rep,2010,2 (1): e9.
    [10] Zhang X,Schlaak M,Fabri M, et al.Successful treatment of a panniculitis-like primary cutaneous T-Cell lymphoma of the α/β type with bexarotene[J].Case Rep Dennatol,2012,4(1):56-60.
    [11] Bashey S,Krathen M,Abdulla F, et al.Romidepsin is effective in subcutaneous panniculitis-like T-cell lymphoma[J].J Clin Oncol, 2012,30(24):e221-225.
    [12] Nagai K, Nakano N, Iwai T, et al. Pediatric subcutaneous panniculitis-like T-cell lymphoma with favorable result by immunosuppressive therapy: a report of two cases[J]. Pediatr Hematol Oncol,2014,31 (6): 528-533.
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  • 收稿日期:  2015-02-11
  • 修回日期:  2015-05-14

乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析

doi: 10.3969/j.issn.1006-0111.2015.04.019

摘要: 目的 探讨乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤(SPTCL)伴噬血细胞综合征(HPS)的临床特征和治疗方法。 方法 回顾性分析2014年8月第二军医大学附属东方肝胆外科医院1例乙肝肝硬化并发SPTCL伴HPS病例的临床资料。 结果 T细胞受体(TCR)表型不同则该病的侵袭性、治疗反应性及预后明显不同,伴HPS者治疗效果不佳,生存期短。 结论 乙肝肝硬化并发SPTCL伴HPS罕见,早期骨髓形态学、病理学、免疫组化及基因重排检测对确诊有重要意义,及早有效控制乙肝病毒尤为重要。早期诊断及治疗对延长患者生存期有重要意义。

English Abstract

杨喜晶, 周福平, 张迁, 钱其军. 乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析[J]. 药学实践与服务, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
引用本文: 杨喜晶, 周福平, 张迁, 钱其军. 乙肝肝硬化并发皮下脂膜炎样T细胞淋巴瘤伴噬血细胞综合征的治疗分析[J]. 药学实践与服务, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
Citation: YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
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