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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

脑缺血和再灌注损伤与防治机制的研究进展

吴金华 马慧萍 蒙萍 贾正平

吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
引用本文: 吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
Citation: WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001

脑缺血和再灌注损伤与防治机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.001
基金项目: 国家科技部重大专项资助项目(2008ZXJ09014-010);甘肃省省自然科学研究基金计划项目(1107RJZA100);全军医药卫生科研基金课题(CLZ11JA06).

Mechanisms of damage and treatments of cerebral ischemia and reperfusion

  • 摘要: 总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。
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  • 收稿日期:  2013-06-07
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脑缺血和再灌注损伤与防治机制的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.001
    基金项目:  国家科技部重大专项资助项目(2008ZXJ09014-010);甘肃省省自然科学研究基金计划项目(1107RJZA100);全军医药卫生科研基金课题(CLZ11JA06).

摘要: 总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。

English Abstract

吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
引用本文: 吴金华, 马慧萍, 蒙萍, 贾正平. 脑缺血和再灌注损伤与防治机制的研究进展[J]. 药学实践与服务, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
Citation: WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping. Mechanisms of damage and treatments of cerebral ischemia and reperfusion[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
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