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小檗碱的结构改造及其药理活性的研究进展

金鑫 宋霞 曹永兵 姜远英 孙青龑

金鑫, 宋霞, 曹永兵, 姜远英, 孙青龑. 小檗碱的结构改造及其药理活性的研究进展[J]. 药学实践与服务, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
引用本文: 金鑫, 宋霞, 曹永兵, 姜远英, 孙青龑. 小檗碱的结构改造及其药理活性的研究进展[J]. 药学实践与服务, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
JIN Xin, SONG Xia, CAO Yongbin, JIANG Yuanying, SUN Qingyan. Research progress in structural modification and pharmacological activities of berberine[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
Citation: JIN Xin, SONG Xia, CAO Yongbin, JIANG Yuanying, SUN Qingyan. Research progress in structural modification and pharmacological activities of berberine[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003

小檗碱的结构改造及其药理活性的研究进展

doi: 10.3969/j.issn.1006-0111.2014.03.003

Research progress in structural modification and pharmacological activities of berberine

  • 摘要: 小檗碱是从中草药黄连等植物中提取并分离得到的一类异喹啉类生物碱。近年来合成了大量小檗碱衍生物,并且发现了广泛的生理功能,其潜在的结构改造和开发应用价值很大。笔者对这些文献进行了较为系统的分析和整理,通过小檗碱不同位点的衍生物所展现的丰富的药理活性,为以小檗碱作为先导物进行的结构改造及创新药物提供了比较系统的信息。
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  • [1] 张成中, 朱雪艳, 卜其涛, 王宏瑞, 黄宝康.  基于网络药理学与分子对接预测鸡骨草特征图谱研究 . 药学实践与服务, 2024, 42(7): 1-9. doi: 10.12206/j.issn.2097-2024.202303048
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  • 收稿日期:  2013-09-24
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小檗碱的结构改造及其药理活性的研究进展

doi: 10.3969/j.issn.1006-0111.2014.03.003

摘要: 小檗碱是从中草药黄连等植物中提取并分离得到的一类异喹啉类生物碱。近年来合成了大量小檗碱衍生物,并且发现了广泛的生理功能,其潜在的结构改造和开发应用价值很大。笔者对这些文献进行了较为系统的分析和整理,通过小檗碱不同位点的衍生物所展现的丰富的药理活性,为以小檗碱作为先导物进行的结构改造及创新药物提供了比较系统的信息。

English Abstract

金鑫, 宋霞, 曹永兵, 姜远英, 孙青龑. 小檗碱的结构改造及其药理活性的研究进展[J]. 药学实践与服务, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
引用本文: 金鑫, 宋霞, 曹永兵, 姜远英, 孙青龑. 小檗碱的结构改造及其药理活性的研究进展[J]. 药学实践与服务, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
JIN Xin, SONG Xia, CAO Yongbin, JIANG Yuanying, SUN Qingyan. Research progress in structural modification and pharmacological activities of berberine[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
Citation: JIN Xin, SONG Xia, CAO Yongbin, JIANG Yuanying, SUN Qingyan. Research progress in structural modification and pharmacological activities of berberine[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
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