留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

硬脂酸镁在直接压片工艺中产生的软化效应

王涛

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
引用本文: 王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
Citation: WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

Decreasing tablet strength of magnesium stearate in direct compression technology

  • 摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。
  • [1] 屠锡德. 水溶性润滑剂[J]. 中国医院药学杂志, 1984, 4(10):21-22.
    [2] 郭仁庭, 覃忠富, 傅长明, 等. 硬脂酸镁的性质、应用及市场前景综述[J]. 企业科技与发展, 2011, 7:15-17.
    [3] Patel S, Kaushal AM, Bansal AK. Lubrication potential of magnesium stearate studied on instrumented rotary tablet press[J]. AAPS Pharm Sci Tech, 2007,8 (4):E1-E8.
    [4] Leinonen UI, Jalonen HU, Vihervaara PA, et al. Physical and lubrication properties of magnesium stearate[J]. J Pharm Sci, 1992, 81(12):1194-1198.
    [5] De Boer AH, Bolhuis GK, Lerk CF. Bonding characteristics by scanning electron microscopy of powders mixed with magnesium stearate[J]. Powder Tech, 1978, 20:75-82.
    [6] Zuurman K, Van der Voort Maarschalk K, Bolhuis GK. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. Int J Pharm, 1999, 179(1):107-115.
    [7] Van Der Watt JG. The effect of the particle size of microcrystalline cellulose on tablet properties in mixtures with magnesium stearate[J]. Int J Pharm, 1987, 36:51-54.
    [8] Almaya A, Aburub A. Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants[J]. AAPS Pharm Sci Tech, 2008, 9(2):414-418.
    [9] Bos CE, Bolhuis GK, van Doorne H, et al. Native starch in tablet formulations:properties on compaction[J]. Pharm Weekbl Sci, 1987, 9:274-282.
    [10] Kikuta J I, Kitamori N. Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets[J]. Drug Devel Industr Pharm, 1994, 20(3):343-355.
    [11] 高春生, 王 玮, 黄 健, 等. 直接压片辅料Cellactose 80的粉体学性能评价[J].中国药学杂志, 2007, 42(2):128-131.
    [12] 郑俊民. 药用辅料手册[M]. 北京:化学工业出版社,2005:407.
    [13] Mehrotra A, Llusa M, Faqih AM, et al. Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate[J]. Int J Pharm, 2007, 336:284-291.
    [14] Matthew J,Mollan Jr, Celik M. The effects of lubrication on the compaction and post-compaction properties of directly compressible maltodextrins[J]. Int J Pharm, 1996, 144(1):1-9.
    [15] 范晓文, 陈大为, 王洪光,等. 硬脂酸镁对黄片颗粒可压性的影响[J]. 中成药, 1997, 19(9):6-8.
    [16] Uĝurlu T, Halacoĝlu MD, Türkoĝlu M. Effects of lubricants on binary direct compression mixtures[J]. Drug DiscTherap, 2010, 4(2):123-128.
    [17] Bolhuis GK, Lerk CF, Zijlstra HT, et al. Film formation by magnesium stearate during mixing and its effect on tabletting[J]. Pharm Weekbl Sci,1975, 110:317-325.
    [18] Yamamura T, Ohta T, Taira T, et al. Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride[J]. Int J Pharm, 2009, 370(1-2):1-7.
    [19] 胡大为, 胡小芳, 林丽莹. 粉体粒度分布分形维数与流动性及硬脂酸镁改进流动性关系[J]. 中国粉体技术, 2007, 4:1-4.
    [20] 王 弘, 陈宜鸿, 马培琴. 粉体特性的研究进展[J]. 中国新药杂志, 2006, 15(18):1535-1539.
    [21] Rowe RC. Interaction of lubricants with microcrystalline cellulose and anhydrous lactose-a solubility parameter approach[J]. Int J Pharm, 1988, 41:223-226.
    [22] 周 莉, 姜继运. 菲特压片机的优势及新应用[J]. 机电信息,2009, 29:33-35.
    [23] 伍善根. 压片工艺中润滑剂技术的研究和进步[J]. 机电信息, 2011, 2:16-19.
    [24] 张益兰, 田 超, 胡丹蓉, 等. 直接压片辅料LubriTose AN的粉体学评价[J]. 药学学报,2012, 47 (5):640-645.
  • [1] 王耀振, 徐灿, 吕顺莉, 田泾, 张东炜.  钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 1-7. doi: 10.12206/j.issn.2097-2024.202306040
  • 加载中
计量
  • 文章访问数:  2757
  • HTML全文浏览量:  398
  • PDF下载量:  333
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-06-28
  • 修回日期:  2013-11-06

硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。

English Abstract

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
引用本文: 王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
Citation: WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
参考文献 (24)

目录

    /

    返回文章
    返回