留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

硬脂酸镁在直接压片工艺中产生的软化效应

王涛

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
引用本文: 王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
Citation: WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

Decreasing tablet strength of magnesium stearate in direct compression technology

  • 摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。
  • [1] 屠锡德. 水溶性润滑剂[J]. 中国医院药学杂志, 1984, 4(10):21-22.
    [2] 郭仁庭, 覃忠富, 傅长明, 等. 硬脂酸镁的性质、应用及市场前景综述[J]. 企业科技与发展, 2011, 7:15-17.
    [3] Patel S, Kaushal AM, Bansal AK. Lubrication potential of magnesium stearate studied on instrumented rotary tablet press[J]. AAPS Pharm Sci Tech, 2007,8 (4):E1-E8.
    [4] Leinonen UI, Jalonen HU, Vihervaara PA, et al. Physical and lubrication properties of magnesium stearate[J]. J Pharm Sci, 1992, 81(12):1194-1198.
    [5] De Boer AH, Bolhuis GK, Lerk CF. Bonding characteristics by scanning electron microscopy of powders mixed with magnesium stearate[J]. Powder Tech, 1978, 20:75-82.
    [6] Zuurman K, Van der Voort Maarschalk K, Bolhuis GK. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. Int J Pharm, 1999, 179(1):107-115.
    [7] Van Der Watt JG. The effect of the particle size of microcrystalline cellulose on tablet properties in mixtures with magnesium stearate[J]. Int J Pharm, 1987, 36:51-54.
    [8] Almaya A, Aburub A. Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants[J]. AAPS Pharm Sci Tech, 2008, 9(2):414-418.
    [9] Bos CE, Bolhuis GK, van Doorne H, et al. Native starch in tablet formulations:properties on compaction[J]. Pharm Weekbl Sci, 1987, 9:274-282.
    [10] Kikuta J I, Kitamori N. Effect of mixing time on the lubricating properties of magnesium stearate and the final characteristics of the compressed tablets[J]. Drug Devel Industr Pharm, 1994, 20(3):343-355.
    [11] 高春生, 王 玮, 黄 健, 等. 直接压片辅料Cellactose 80的粉体学性能评价[J].中国药学杂志, 2007, 42(2):128-131.
    [12] 郑俊民. 药用辅料手册[M]. 北京:化学工业出版社,2005:407.
    [13] Mehrotra A, Llusa M, Faqih AM, et al. Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate[J]. Int J Pharm, 2007, 336:284-291.
    [14] Matthew J,Mollan Jr, Celik M. The effects of lubrication on the compaction and post-compaction properties of directly compressible maltodextrins[J]. Int J Pharm, 1996, 144(1):1-9.
    [15] 范晓文, 陈大为, 王洪光,等. 硬脂酸镁对黄片颗粒可压性的影响[J]. 中成药, 1997, 19(9):6-8.
    [16] Uĝurlu T, Halacoĝlu MD, Türkoĝlu M. Effects of lubricants on binary direct compression mixtures[J]. Drug DiscTherap, 2010, 4(2):123-128.
    [17] Bolhuis GK, Lerk CF, Zijlstra HT, et al. Film formation by magnesium stearate during mixing and its effect on tabletting[J]. Pharm Weekbl Sci,1975, 110:317-325.
    [18] Yamamura T, Ohta T, Taira T, et al. Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride[J]. Int J Pharm, 2009, 370(1-2):1-7.
    [19] 胡大为, 胡小芳, 林丽莹. 粉体粒度分布分形维数与流动性及硬脂酸镁改进流动性关系[J]. 中国粉体技术, 2007, 4:1-4.
    [20] 王 弘, 陈宜鸿, 马培琴. 粉体特性的研究进展[J]. 中国新药杂志, 2006, 15(18):1535-1539.
    [21] Rowe RC. Interaction of lubricants with microcrystalline cellulose and anhydrous lactose-a solubility parameter approach[J]. Int J Pharm, 1988, 41:223-226.
    [22] 周 莉, 姜继运. 菲特压片机的优势及新应用[J]. 机电信息,2009, 29:33-35.
    [23] 伍善根. 压片工艺中润滑剂技术的研究和进步[J]. 机电信息, 2011, 2:16-19.
    [24] 张益兰, 田 超, 胡丹蓉, 等. 直接压片辅料LubriTose AN的粉体学评价[J]. 药学学报,2012, 47 (5):640-645.
  • [1] 王耀振, 徐灿, 吕顺莉, 田泾, 张东炜.  钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
    [2] 郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛.  醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202310043
  • 加载中
计量
  • 文章访问数:  3149
  • HTML全文浏览量:  444
  • PDF下载量:  336
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-06-28
  • 修回日期:  2013-11-06

硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。

English Abstract

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
引用本文: 王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
Citation: WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005
参考文献 (24)

目录

    /

    返回文章
    返回