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叶酸在心脑血管疾病防治中的机遇与挑战

成彦琼 张浩 王威 顾小飞 刘爱军

成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
引用本文: 成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003

叶酸在心脑血管疾病防治中的机遇与挑战

doi: 10.3969/j.issn.1006-0111.2013.05.003
基金项目: 国家自然科学基金资助项目(81273505).

New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases

  • 摘要: 叶酸缺乏可导致高同型半胱氨酸血症,而高同型半胱氨酸血症是心脑血管疾病的独立危险因素。过去认为补充叶酸可降低体内同型半胱氨酸水平,从而预防心脑血管疾病的发生。但随着大量临床随机对照试验的进行,人们发现降低同型半胱氨酸血症并不能为心血管疾病患者带来益处,脑卒中方面的益处还需要更多临床数据证明。叶酸等B族维生素在心脑血管疾病的预防领域还存在着很大的挑战。笔者就目前叶酸等在心脑血管疾病中的应用现状及存在问题作一综述。
  • [1] Collaboration HLT.Lowering blood homocysteine with folic acid based supplements:meta-analysis of randomized trials [J].BMJ,1998,316(7135):894.
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    [22] SEARCH Study Collaborative Group,Bowman L,Armitage J,et al.Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12 064 myocardial infarction survivors[J].Am Heart J,2007,154(5):815.
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  • 收稿日期:  2012-12-14
  • 修回日期:  2013-04-08

叶酸在心脑血管疾病防治中的机遇与挑战

doi: 10.3969/j.issn.1006-0111.2013.05.003
    基金项目:  国家自然科学基金资助项目(81273505).

摘要: 叶酸缺乏可导致高同型半胱氨酸血症,而高同型半胱氨酸血症是心脑血管疾病的独立危险因素。过去认为补充叶酸可降低体内同型半胱氨酸水平,从而预防心脑血管疾病的发生。但随着大量临床随机对照试验的进行,人们发现降低同型半胱氨酸血症并不能为心血管疾病患者带来益处,脑卒中方面的益处还需要更多临床数据证明。叶酸等B族维生素在心脑血管疾病的预防领域还存在着很大的挑战。笔者就目前叶酸等在心脑血管疾病中的应用现状及存在问题作一综述。

English Abstract

成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
引用本文: 成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
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