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抗真菌药物靶标及其抑制剂的研究进展

徐波 蒋琰 张万年 盛春泉

徐波, 蒋琰, 张万年, 盛春泉. 抗真菌药物靶标及其抑制剂的研究进展[J]. 药学实践与服务, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
引用本文: 徐波, 蒋琰, 张万年, 盛春泉. 抗真菌药物靶标及其抑制剂的研究进展[J]. 药学实践与服务, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
XU Bo, JIANG Yan, ZHANG Wan-nian, SHENG Chun-quan. Progress on antifungal drug targets and inhibitors[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
Citation: XU Bo, JIANG Yan, ZHANG Wan-nian, SHENG Chun-quan. Progress on antifungal drug targets and inhibitors[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001

抗真菌药物靶标及其抑制剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.05.001
基金项目: 国家自然科学基金重点项目(30930107).

Progress on antifungal drug targets and inhibitors

  • 摘要: 目的 综述抗真菌药物靶标及其抑制剂的研究进展。 方法 本文结合自身研究工作,分析近5年文献,总结抗真菌药物靶标及其抑制剂的最新进展。 结果 β-1,3-葡聚糖合成酶、羊毛甾醇 14α-去甲基化酶、N-肉豆蔻酰基转移酶和分泌型天冬氨酸蛋白酶是目前研究最为集中的抗真菌药靶,其抑制剂显示了良好的新药开发前景。 结论 优化现有药物化学结构和发现全新作用机制的先导化合物,对研发新一代抗真菌药物具有重要意义。
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  • 收稿日期:  2012-12-14
  • 修回日期:  2013-04-08

抗真菌药物靶标及其抑制剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.05.001
    基金项目:  国家自然科学基金重点项目(30930107).

摘要: 目的 综述抗真菌药物靶标及其抑制剂的研究进展。 方法 本文结合自身研究工作,分析近5年文献,总结抗真菌药物靶标及其抑制剂的最新进展。 结果 β-1,3-葡聚糖合成酶、羊毛甾醇 14α-去甲基化酶、N-肉豆蔻酰基转移酶和分泌型天冬氨酸蛋白酶是目前研究最为集中的抗真菌药靶,其抑制剂显示了良好的新药开发前景。 结论 优化现有药物化学结构和发现全新作用机制的先导化合物,对研发新一代抗真菌药物具有重要意义。

English Abstract

徐波, 蒋琰, 张万年, 盛春泉. 抗真菌药物靶标及其抑制剂的研究进展[J]. 药学实践与服务, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
引用本文: 徐波, 蒋琰, 张万年, 盛春泉. 抗真菌药物靶标及其抑制剂的研究进展[J]. 药学实践与服务, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
XU Bo, JIANG Yan, ZHANG Wan-nian, SHENG Chun-quan. Progress on antifungal drug targets and inhibitors[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
Citation: XU Bo, JIANG Yan, ZHANG Wan-nian, SHENG Chun-quan. Progress on antifungal drug targets and inhibitors[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 321-325,379. doi: 10.3969/j.issn.1006-0111.2013.05.001
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