Preparation of nicardipine hydrochloride sustained-release pellets
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摘要: 目的 制备盐酸尼卡地平缓释微丸,并考察其体外释药的影响因素。 方法 采用底喷式流化床包衣法,以空白丸芯为基础制备速释微丸,乙基纤维素水分散体为包衣材料制备盐酸尼卡地平缓释微丸,考察其包衣处方及工艺的影响因素。 结果 所得缓释微丸在2、6、12 h的累积释药百分率分别为24%、69%、87%,体外释放曲线符合一级方程。 结论 制备的微丸缓释效果理想,且制备工艺简单,操作方便。Abstract: Objective To prepare nicardipine hydrochloride sustained-release pellets and investigate the influencing factors of the drug release in vitro. Methods The rapid-release pellets were prepared by fluidized bed coating method based on blank pill core and then nicardipine hydrochloride sustained-release pellets were prepared with surelease. The factors to influence the drug release behaviors and their properties were evaluated. Results The release percentage of the sustained-release pellets could be controlled by 24%, 69%, 87% at 2 h, 6 h, 12 h respectively, the drug release mechanism in vitro followed first-order equations. Conclusion The pellets showed an obviously sustained-release effect.The preparation process was simple and convenient.
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Key words:
- nicardipine hydrochloride /
- surelease /
- sustained-release pellets /
- fluidized bed
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