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2-位取代苯并呋喃类化合物的生物活性及合成研究进展

陈焕 李科

陈焕, 李科. 2-位取代苯并呋喃类化合物的生物活性及合成研究进展[J]. 药学实践与服务, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
引用本文: 陈焕, 李科. 2-位取代苯并呋喃类化合物的生物活性及合成研究进展[J]. 药学实践与服务, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
CHEN Huan, LI Ke. Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
Citation: CHEN Huan, LI Ke. Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002

2-位取代苯并呋喃类化合物的生物活性及合成研究进展

doi: 10.3969/j.issn.1006-0111.2013.01.002

Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives

  • 摘要: 苯并呋喃衍生物是当前研究杂环芳香族化合物的热点之一。据文献报道该类化合物具有抗肿瘤,抗氧化,钙内流阻滞,血管紧张素II受体拮抗,腺苷A1受体拮抗,抗真菌、抗菌活性和血小板聚集拮抗等药理作用。由于苯并呋喃具有广泛活性,因此吸引很多学者对其进行研究。为了更好地研究该类化合物的合成和生物活性,本文对近几年来文献报道的具有良好生物活性的2-位取代苯并呋喃衍生物进行综述,并对它们的合成方法进行概括,为开发新型2-取代苯并呋喃类化合物提供参考。
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    [7] Romeo R, Pier G, Taradas S,et al. Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization[J]. Bioorg Med Chem, 2008, 16(18): 8419.
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    [11] Manish D, Brajendra K, Akhilesh K,et al. Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors[J]. Bioorg Med Chem, 2007, 15(2): 727.
    [12] Kuntal M, Yadvendra K, Agrawa D,et al. Synthesis, and antitubercular evaluation of novel series benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs[J]. Eur J Med Chem, 2010, 10(9): 1016.
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    [14] Bernd P, Sonja B, Rolf H,et al. Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor[J]. Bioorg Med Chem Lett, 2006, 16(12): 3162.
    [15] Jung WH, Da HC, Jae H,et al. Facile Preparation of 2-Arylbenzo[b]furan Molecules and Their Antiinflammatory Effects[J]. Bull Korean Chem Soc, 2010, 31(4): 4965.
    [16] Michael CW, Dawn T, Adam TG,et al. Palladium-catalysed intramolecular enolate O-arylation and thio-enolate S-arylation: synthesis of benzo[b]furans and benzo[b]thiophenes[J]. Tetrahedron,2006, 62(49): 11513.
    [17] Sanjay SP, Vijaykumar S, More KV,et al. Ultrasound promoted copper-, ligand-and amine-free synthesis of benzo [b]furans/nitro benzo[b]furans via Sonogashira coupling-5-endo-dig-cyclization[J]. Ultrason Sonochem, 2008, 15(5): 853.
    [18] Antonella B, Lucia C, Maria F,et al. Effcient synthesis of 5-nitro-benzo[b]furans via 2-bromo-4-nitro-phenyl acetates[J]. Tetrahedron Lett, 2010, 51(21): 2824.
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    [20] Pei LX,Li YM,Bu XI,et al. One-pot synthesis of 5.6-dihydroxylated benzo[b]furan derivatives[J]. Tetrahedron Lett, 2006, 47(15): 2615.
    [21] Li HF,Liu J,Yan B,et al. Newdomino approach for the synthesis of 2,3-disubstituted benzo[b]furans via copper-catalyzed multi-component coupling reactions followed by cyclization[J]. Tetrahedron Lett, 2009, 50(20): 2353.
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  • 收稿日期:  2011-03-14
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2-位取代苯并呋喃类化合物的生物活性及合成研究进展

doi: 10.3969/j.issn.1006-0111.2013.01.002

摘要: 苯并呋喃衍生物是当前研究杂环芳香族化合物的热点之一。据文献报道该类化合物具有抗肿瘤,抗氧化,钙内流阻滞,血管紧张素II受体拮抗,腺苷A1受体拮抗,抗真菌、抗菌活性和血小板聚集拮抗等药理作用。由于苯并呋喃具有广泛活性,因此吸引很多学者对其进行研究。为了更好地研究该类化合物的合成和生物活性,本文对近几年来文献报道的具有良好生物活性的2-位取代苯并呋喃衍生物进行综述,并对它们的合成方法进行概括,为开发新型2-取代苯并呋喃类化合物提供参考。

English Abstract

陈焕, 李科. 2-位取代苯并呋喃类化合物的生物活性及合成研究进展[J]. 药学实践与服务, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
引用本文: 陈焕, 李科. 2-位取代苯并呋喃类化合物的生物活性及合成研究进展[J]. 药学实践与服务, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
CHEN Huan, LI Ke. Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
Citation: CHEN Huan, LI Ke. Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 5-10,71. doi: 10.3969/j.issn.1006-0111.2013.01.002
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