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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

基于疾病动物模型的中药药动学研究进展

王韵 柴逸峰 朱臻宇

王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
引用本文: 王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003

基于疾病动物模型的中药药动学研究进展

doi: 10.3969/j.issn.1006-0111.2017.02.003
基金项目: 国家自然科学基金资助项目(81273472, 81573396)

Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

  • 摘要: 中药药动学是中药现代化研究必不可少的环节,是中医药与世界接轨的重要手段。药物在作用部位只有达到足够浓度,才能在体内发挥药效,而药物浓度不仅与给药剂量有关,亦受到药物体内过程的影响。传统中药药动学研究多基于健康实验动物展开,忽视了疾病状态下生理和病理变化可能引起相关药动学参数显著改变。本文系统综述了近年来基于常见疾病动物模型开展的中药药动学比较研究,并对不同动物模型药动学比较的研究发展趋势进行讨论和展望。
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  • 收稿日期:  2016-12-05
  • 修回日期:  2016-12-27

基于疾病动物模型的中药药动学研究进展

doi: 10.3969/j.issn.1006-0111.2017.02.003
    基金项目:  国家自然科学基金资助项目(81273472, 81573396)

摘要: 中药药动学是中药现代化研究必不可少的环节,是中医药与世界接轨的重要手段。药物在作用部位只有达到足够浓度,才能在体内发挥药效,而药物浓度不仅与给药剂量有关,亦受到药物体内过程的影响。传统中药药动学研究多基于健康实验动物展开,忽视了疾病状态下生理和病理变化可能引起相关药动学参数显著改变。本文系统综述了近年来基于常见疾病动物模型开展的中药药动学比较研究,并对不同动物模型药动学比较的研究发展趋势进行讨论和展望。

English Abstract

王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
引用本文: 王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
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