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人类乙醛脱氢酶II及其激动剂的研究进展

田巍 王涛 郑灿辉 董国强 吕加国 朱驹

田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹. 人类乙醛脱氢酶II及其激动剂的研究进展[J]. 药学实践与服务, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
引用本文: 田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹. 人类乙醛脱氢酶II及其激动剂的研究进展[J]. 药学实践与服务, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
Citation: TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

人类乙醛脱氢酶II及其激动剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.02.004

Progress on Human aldehyde dehydrogenase II and its agonists

  • 摘要: 人类乙醛脱氢酶II (aldehyde dehydrogenasesII,ALDH2) 具有脱氢酶和酯酶等多种酶的功能,ALDH2活性的增强将减轻因酒精、缺血等多种因素引起的肝脏、心肌损伤及某些癌症的发生。本文通过对国内外文献的分析、整理和归纳,较为全面的介绍了ALDH2及其激动剂的研究现状。
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    [4] 何 岚,彭 军.线粒体醛脱氢酶对心脏保护作用的研究进展[J].中国药理学通报,2009,25:1548.
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    [21] Grant RB, Marie HD, Daria MR. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
    [22] Samantha PM, Hina Y, Ram V, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology, 2010,17:159.
    [23] Feldman RI, Weiner H. Horse liver aldehyde dehydrogenaseII Kinetics and mechanistic implications of the dehydrogenase and esterase activity[J]. J Biol Chem, 1972,5:267.
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    [26] Perez MS, Hurley TD. Coenzyme isomerization is integral to catalysis in human aldehyde dehydrogenase[J]. Biochemistry, 2003,42:7100.
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  • 收稿日期:  2012-04-26
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人类乙醛脱氢酶II及其激动剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.02.004

摘要: 人类乙醛脱氢酶II (aldehyde dehydrogenasesII,ALDH2) 具有脱氢酶和酯酶等多种酶的功能,ALDH2活性的增强将减轻因酒精、缺血等多种因素引起的肝脏、心肌损伤及某些癌症的发生。本文通过对国内外文献的分析、整理和归纳,较为全面的介绍了ALDH2及其激动剂的研究现状。

English Abstract

田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹. 人类乙醛脱氢酶II及其激动剂的研究进展[J]. 药学实践与服务, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
引用本文: 田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹. 人类乙醛脱氢酶II及其激动剂的研究进展[J]. 药学实践与服务, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
Citation: TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004
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