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作为基因输送载体的壳聚糖衍生物研究进展

李晏

李晏. 作为基因输送载体的壳聚糖衍生物研究进展[J]. 药学实践与服务, 2011, 29(1): 8-10,61.
引用本文: 李晏. 作为基因输送载体的壳聚糖衍生物研究进展[J]. 药学实践与服务, 2011, 29(1): 8-10,61.
LI Yan. Research progress of chitosan derivatives as gene delivery vector[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 8-10,61.
Citation: LI Yan. Research progress of chitosan derivatives as gene delivery vector[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 8-10,61.

作为基因输送载体的壳聚糖衍生物研究进展

Research progress of chitosan derivatives as gene delivery vector

  • 摘要: 壳聚糖作为基因载体,目前存在的主要问题是还不能达到足够高的表达效率。其中主要原因是壳聚糖在pH 7.4的生理环境下溶解度较差,壳聚糖与DNA形成的复合物在生理环境下的稳定性较差,缺乏细胞靶向性。本文综述了作为基因输送载体的壳聚糖衍生物研究进展,为进一步研究和开发壳聚糖衍生物提供依据和参考。
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    [13] Li W, Nicol F, Szoka Jr FC, GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery[J]. Adv Drug Deliv Rev, 2004, (56) :967.
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    [19] Satoh T, Kano H, Nakatani M, et al. 6-Amino-6-deoxy chitosan. Sequential chemical modifications at the C-6 positions of N-phthaloylchitosan and evaluation as a gene carrier[J].Carbohydr Res,. 2006, (341) : 2406.
    [20] Park IK, Ihm JE, Park YH, et al. Galactosylated chitosan(GC)-graftpoly(vinyl pyrrolidone) (PVP) as hepatocytetargeting DNA carrier: preparation and physicochemical characterization of GCgraft-PVP/DNA complex (1) [J]. J Control Release,2003, (86) : 349.
    [21] Wong K, Sun G, Zhang X, et al. PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo[J].Bioconjug Chem,2006, (17) : 152.
    [22] Kurisawa M, Yokoyama M, Okano T, Transfection efficiency increases by incorporating hydrophobicmonomer units into polymeric gene carriers[J].J Control Release,2000, (68) : 1.
    [23] Kim YH, Gihm SH, Park CR, et al. Structural characteristics of size-controlled self aggregates of deoxycholic acidmodified chitosan and their application as a DNA delivery carrier[J].Bioconjugate Chem,2001 ,(12) : 932.
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    [26] Mao Z, Ma L, Yan J, et al. The gene transfection efficiency of thermoresponsive N, N, N-trimethyl chitosan chloride-g-poly(N-isopropylacrylamide) copolymer[J]. Biomaterials,2007, (28) : 4488.
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  • 收稿日期:  2010-09-20
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作为基因输送载体的壳聚糖衍生物研究进展

摘要: 壳聚糖作为基因载体,目前存在的主要问题是还不能达到足够高的表达效率。其中主要原因是壳聚糖在pH 7.4的生理环境下溶解度较差,壳聚糖与DNA形成的复合物在生理环境下的稳定性较差,缺乏细胞靶向性。本文综述了作为基因输送载体的壳聚糖衍生物研究进展,为进一步研究和开发壳聚糖衍生物提供依据和参考。

English Abstract

李晏. 作为基因输送载体的壳聚糖衍生物研究进展[J]. 药学实践与服务, 2011, 29(1): 8-10,61.
引用本文: 李晏. 作为基因输送载体的壳聚糖衍生物研究进展[J]. 药学实践与服务, 2011, 29(1): 8-10,61.
LI Yan. Research progress of chitosan derivatives as gene delivery vector[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 8-10,61.
Citation: LI Yan. Research progress of chitosan derivatives as gene delivery vector[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 8-10,61.
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