复方茵虎汤对实验性肝损伤的保护作用
Protective effect of compound Yinhu decoction on experimental liver injury
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摘要: 目的:本实验研究复方茵虎汤(复方茵虎汤)对四氯化碳致小鼠肝损伤的保护作用。方法:以腹腔注射四氯化碳(CCl4)建立小鼠肝损伤模型,以复方茵虎汤作为受试药物,以联苯双酯作为阳性对照药物,以肝指数(LI)、血清中谷氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、肝组织匀浆中超氧化物歧化酶(SOD)和丙二醛(MDA)水平为检测指标,观察复方茵虎汤对肝损伤的保护作用。结果:复方茵虎汤能够明显降低CCl4致小鼠肝损伤血清中ALT和AST水平,升高肝组织中SOD水平,降低肝组织中MDA水平,减轻四氯化碳对肝脏细胞的病理损伤。结论:复方茵虎汤对CCl4致小鼠急性肝损伤有一定的保护作用。Abstract: Objective : To observe the protective effect of Compound Yinhu decoction on acute liver injury induced by carbon tetrachloride(CCl4) in mice. Methods : Acute liver injury was established by intraperitoneal injection of CCl4.Compound Yinhu decotion was tested as subjects drug and bifendate as a positive control drug.The liver index(LI),the levels of serum alanine amino-transferase(ALT) and aspartate amino-transferase(AST),the superoxide dismutase(SOD) and molondialdehyde(MDA) levels in the liver tissue were measured and the protective effect of Compound Yinhu decotion on liver injury was observed. Results :Compound Yinhu decotion could significantly reduce serum ALT and AST levels,increase liver SOD level and decrease liver MDA level.It could also reduce the liver cell morphological injury. Conclusions :Compound Yinhu decotion has some protective effect on acute liver injury induced by CCl4 in mice.
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