川芎、当归超临界CO2萃取液对犬血液动力学的影响
Effects of extract liquid of Lifusticum chuanxiong and Angelica on hemodynamics of dogs
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摘要: 目的 观察不同剂量的CO2超临界川芎、当归萃取液对犬脑血液动力学的影响。方法 各实验组十二指肠给药(5ml·kg-1)后记录其脑血流量及血压的改变,并将同组各动物对应的脑血流量、血压进行统计学处理。结果 给川芎、当归萃取液及阳性药物(脑安胶囊),脑血流平均变动幅度与溶剂对照组相比,具有显著性差异,而平均血压变动无显著性差异。结论 川芎、当归萃取液对脑血液动力学有影响,可使犬脑的血流量显著增加,而对血压没有明显的作用。Abstract: OBJECTIVE To observe the effects of cerebral hemodynamics on different dosages of extract liquid of Lifusticum chuanxiong and Angelica in dogs. METHODS to record changes of cerebral blood flow(CBF) and blood pressure (BP) after feeding medicines by duodenum and process datum of every group of dogs by analysing datum statistically. RESULTS The average changeable range of CBF with extract liquid of Lifusticum and Angelica and positive medicines (Nao'an capsule) was significant and average changeable range of BP wasn't apparent as compared with solvent control group. CONCLUSION Extract liquid of Lifusticum and Angelica had effects on cerebral hemodynamics and increased CBF,but had no effects on changes of BP.
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