2011 Vol. 29, No. 6
Display Method:
2011, 29(6): 401-404.
Abstract:
Paederia scandens (Lour.) Merri., a climbing plant, belonging to the family Rubiaceae, was a commonly used herbal medicine in folklore medicine. The chemical constituents of Paederia scandens were mainly flavonoids, iridoid glycosides and volatile oils. Paederia scandens had significant effects of anti-nociceptive and anti-inflammatory activities. It was used for curing the pains and gastrointestinal diseases in clinic practice.The chemical constituents, pharmacological effects and clinical practices of Paederia scandens in recent years were summarized. It could provide the scientific basis for the research, development and the clinical application of Paederia scandens in future.
Paederia scandens (Lour.) Merri., a climbing plant, belonging to the family Rubiaceae, was a commonly used herbal medicine in folklore medicine. The chemical constituents of Paederia scandens were mainly flavonoids, iridoid glycosides and volatile oils. Paederia scandens had significant effects of anti-nociceptive and anti-inflammatory activities. It was used for curing the pains and gastrointestinal diseases in clinic practice.The chemical constituents, pharmacological effects and clinical practices of Paederia scandens in recent years were summarized. It could provide the scientific basis for the research, development and the clinical application of Paederia scandens in future.
2011, 29(6): 405-407,448.
Abstract:
In recent years, great achievements had been made in flexibility and controllability of combination of inhalational anesthetics with intravenous drugs for balanced anesthesia. Clinical literature of combined use of opioids and inhalational anesthetics were reviewed to elaborate the progresses in the studies of their interaction. The characteristics of effects of opioids on MACBAR of inhalational anesthetics were focused so as to provide beneficial references in administration of these two types of drugs rationally for safe and effective balanced anesthesia.
In recent years, great achievements had been made in flexibility and controllability of combination of inhalational anesthetics with intravenous drugs for balanced anesthesia. Clinical literature of combined use of opioids and inhalational anesthetics were reviewed to elaborate the progresses in the studies of their interaction. The characteristics of effects of opioids on MACBAR of inhalational anesthetics were focused so as to provide beneficial references in administration of these two types of drugs rationally for safe and effective balanced anesthesia.
2011, 29(6): 408-411,415.
Abstract:
Iodine was one of the most important trace elements in human nutrition. It was essential for the biosynthesis of thyroid hormones, which was closely related with the mental development, growth and basic metabolism. Iodine spead and exist widely in many forms. The analysis methods of iodine in human body, food, medicine and environmental received many attentions. The analysis methods of iodine in biological matrix were reviewed to give some references for the further research.
Iodine was one of the most important trace elements in human nutrition. It was essential for the biosynthesis of thyroid hormones, which was closely related with the mental development, growth and basic metabolism. Iodine spead and exist widely in many forms. The analysis methods of iodine in human body, food, medicine and environmental received many attentions. The analysis methods of iodine in biological matrix were reviewed to give some references for the further research.
2011, 29(6): 412-415.
Abstract:
In recent years, Ervatamia genus plants contained indole alkaloids which had been proved to have good biological activity, had attracted more and more scholars' attention. Research reports in this area had been increasing annually. Many research progresses had been obtained. The research progresses of the domestic Ervatamia genus in late years were reviewed in this paper.
In recent years, Ervatamia genus plants contained indole alkaloids which had been proved to have good biological activity, had attracted more and more scholars' attention. Research reports in this area had been increasing annually. Many research progresses had been obtained. The research progresses of the domestic Ervatamia genus in late years were reviewed in this paper.
2011, 29(6): 416-420,425.
Abstract:
Objective Rheumatoid arthritis (RA) was a systemic autoimmune disease, and known to cause continuous pain, recurrent process, and high rate of disability. It was a kind of diseases which was difficult to cure. Currently, the drug treatment, such as, non-steroidal anti-inflammatory drugs (NSAIDs), hormone drugs, and biological agents, cost too much and produce side effects after long-term utility, which limit their application. Because of the advantages of better efficacy and less side effects, traditional Chinese medicine (TCM) had been widely used for the treatment of RA. Recent progresses in the research of TCM treatment and clinical application of RA were reviewed in this paper.
Objective Rheumatoid arthritis (RA) was a systemic autoimmune disease, and known to cause continuous pain, recurrent process, and high rate of disability. It was a kind of diseases which was difficult to cure. Currently, the drug treatment, such as, non-steroidal anti-inflammatory drugs (NSAIDs), hormone drugs, and biological agents, cost too much and produce side effects after long-term utility, which limit their application. Because of the advantages of better efficacy and less side effects, traditional Chinese medicine (TCM) had been widely used for the treatment of RA. Recent progresses in the research of TCM treatment and clinical application of RA were reviewed in this paper.
2011, 29(6): 421-425.
Abstract:
Of all the compound classes present in G. biloba, the terpene trilactones had received the most attention. The ginkgolides and bilobalide were selective platelet-activating factor antagonists and widely applied in the illness of blood vessel of heart and brain. Studies on the chemical constituents, extraction and separation, the determination of content and the pharmacological activity about terpene trilactones of Ginkgo leaves were summarized and the study prospect were made.
Of all the compound classes present in G. biloba, the terpene trilactones had received the most attention. The ginkgolides and bilobalide were selective platelet-activating factor antagonists and widely applied in the illness of blood vessel of heart and brain. Studies on the chemical constituents, extraction and separation, the determination of content and the pharmacological activity about terpene trilactones of Ginkgo leaves were summarized and the study prospect were made.
2011, 29(6): 426-430.
Abstract:
Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and 1H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhibited activity against fungi tested. Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.
Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and 1H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhibited activity against fungi tested. Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.
2011, 29(6): 431-434.
Abstract:
Objective To observe the hemostasis effect of carbonized hair. Methods The coagulation time was measured in vitro with blood collected from rabbits in the presence of blank, starch, carbonized hair or Yunnan White Drug-Powder respectively. Bama miniature pigs traumatic model was established and animal haemostatic experiment was performed.Hemostatic effect was observed in liver, spleen and femoral arteriovenous fistula hemorrhagic model of Bama miniature pigs. Results The coagulation time of rabbit blood was markedly shorter by addition of carbonized hair compared to Yunnan White Drug-Powder, starch and blank (P<0.05,P<0.01).Compare with the starch group, carbonized hair could significantly shorten the bleeding time and decrease the volume of bleeding (P<0.01), in the liver and spleen of hemorrhagic model of Bama miniature pigs. Compared with the Yunnan White Drug-Powder and the starch, carbonized hair could more effectively stop the femoral arteriovenous fistula bleeding in the model of Bama miniature pigs (P<0.05,P<0.01). Histologic study revealed there was no significant pathological change around the femoral artery. Conclution Carbonized hair could effectively inhibit blood coagulation in vitro, decrease bleeding volume and bleeding time in the liver and spleen of hemorrhagic model of Bama miniature pigs. Carbonized hair dressing could also effectively control hemorrhage in femoral arteriovenous fistula model with lethal vascular injury.
Objective To observe the hemostasis effect of carbonized hair. Methods The coagulation time was measured in vitro with blood collected from rabbits in the presence of blank, starch, carbonized hair or Yunnan White Drug-Powder respectively. Bama miniature pigs traumatic model was established and animal haemostatic experiment was performed.Hemostatic effect was observed in liver, spleen and femoral arteriovenous fistula hemorrhagic model of Bama miniature pigs. Results The coagulation time of rabbit blood was markedly shorter by addition of carbonized hair compared to Yunnan White Drug-Powder, starch and blank (P<0.05,P<0.01).Compare with the starch group, carbonized hair could significantly shorten the bleeding time and decrease the volume of bleeding (P<0.01), in the liver and spleen of hemorrhagic model of Bama miniature pigs. Compared with the Yunnan White Drug-Powder and the starch, carbonized hair could more effectively stop the femoral arteriovenous fistula bleeding in the model of Bama miniature pigs (P<0.05,P<0.01). Histologic study revealed there was no significant pathological change around the femoral artery. Conclution Carbonized hair could effectively inhibit blood coagulation in vitro, decrease bleeding volume and bleeding time in the liver and spleen of hemorrhagic model of Bama miniature pigs. Carbonized hair dressing could also effectively control hemorrhage in femoral arteriovenous fistula model with lethal vascular injury.
2011, 29(6): 435-438.
Abstract:
Objective To analyze chemical constituents of ershen pill by rapid-resolution(high performance) liquid chromatography-time of flight mass spectrometry (HPLC-TOF/MS). Methods A shelloseido column(3.0 mm×100 mm,3 μm) was used to separate. The mobile phase consisted of water containing 0.1% methane acid and acetonitrile was used as gradient elute. The flow rate was 0.6 ml/min. TOF/MS was applied for qualitative analysis under positive ion mode. Results Under LC/MS condition, 21 major constituents in ershen pill were identified by time of flight mass spectrometry, among which, 15 constituents were from Psoralea corylifolia L,and 6 constituents were from Myristica fragrans Houtt. Conclusion A simple and reliable method using HPLC-TOF/MS was established to identify the chemical constituents of ershen pill.
Objective To analyze chemical constituents of ershen pill by rapid-resolution(high performance) liquid chromatography-time of flight mass spectrometry (HPLC-TOF/MS). Methods A shelloseido column(3.0 mm×100 mm,3 μm) was used to separate. The mobile phase consisted of water containing 0.1% methane acid and acetonitrile was used as gradient elute. The flow rate was 0.6 ml/min. TOF/MS was applied for qualitative analysis under positive ion mode. Results Under LC/MS condition, 21 major constituents in ershen pill were identified by time of flight mass spectrometry, among which, 15 constituents were from Psoralea corylifolia L,and 6 constituents were from Myristica fragrans Houtt. Conclusion A simple and reliable method using HPLC-TOF/MS was established to identify the chemical constituents of ershen pill.
2011, 29(6): 439-441.
Abstract:
Objective To study the protective effects of planting Dendrobii caulis and tissue culture planting Dendrobium officinale Kimura et Migo on glutamate damage induced in cultured SH-SY5Y cells. Methods The sera were obtained from rats by using the serum pharmacology method, and cell damage model was established by treating SH-SY5Y cells with glutamate. the proliferation of damaged cells were observed by 72 h. MTT assay was used to test lactate dehydrogenase(LDH), malondialde-1yde(MDA)and superoxide dismutase (SOD) in the culture medium. Results Both planting and tissue culture Dendrobii caulis could promote the cell proliferation of glutamate damaged SH-SY5Y cells. They also could decrease LDH and MDA content and increase SOD level significantly. Tissue cultured Dendrobii caulis preceded planting ones in antioxidant potential. Conclusion Dendrobii caulis had protective effect on glutamate damaged SH-SY5Y cells. The protective effect of tissue culture one, while, was more distinctive than planting one, which could prove that officinal effect of tissue culture Dendrobium huoshanense was preceded to Dendrobium plants.
Objective To study the protective effects of planting Dendrobii caulis and tissue culture planting Dendrobium officinale Kimura et Migo on glutamate damage induced in cultured SH-SY5Y cells. Methods The sera were obtained from rats by using the serum pharmacology method, and cell damage model was established by treating SH-SY5Y cells with glutamate. the proliferation of damaged cells were observed by 72 h. MTT assay was used to test lactate dehydrogenase(LDH), malondialde-1yde(MDA)and superoxide dismutase (SOD) in the culture medium. Results Both planting and tissue culture Dendrobii caulis could promote the cell proliferation of glutamate damaged SH-SY5Y cells. They also could decrease LDH and MDA content and increase SOD level significantly. Tissue cultured Dendrobii caulis preceded planting ones in antioxidant potential. Conclusion Dendrobii caulis had protective effect on glutamate damaged SH-SY5Y cells. The protective effect of tissue culture one, while, was more distinctive than planting one, which could prove that officinal effect of tissue culture Dendrobium huoshanense was preceded to Dendrobium plants.
2011, 29(6): 442-444.
Abstract:
Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynchophylline and isorhynchophylline in total alkaloids among various conditions. Results Comparing with rhynchophylline, isorhynchophylline was unstable to heating. Heated in 60 ℃ and 90 ℃ for 2 hours, isorhynchophylline content decreased more than 38% and 50%, respectively. But rhynchophylline solution was stable in 60 ℃ for 2 hours and 4 ℃ for 6 days. In addition, rhynchophylline and isorhynchophylline were more stable in salt formation. Conclusion Isorhynchophylline was unstable to heating, which was the reason for rhynchophylla to given later.in decoct herbal medicine.
Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynchophylline and isorhynchophylline in total alkaloids among various conditions. Results Comparing with rhynchophylline, isorhynchophylline was unstable to heating. Heated in 60 ℃ and 90 ℃ for 2 hours, isorhynchophylline content decreased more than 38% and 50%, respectively. But rhynchophylline solution was stable in 60 ℃ for 2 hours and 4 ℃ for 6 days. In addition, rhynchophylline and isorhynchophylline were more stable in salt formation. Conclusion Isorhynchophylline was unstable to heating, which was the reason for rhynchophylla to given later.in decoct herbal medicine.
2011, 29(6): 445-448.
Abstract:
Objective To analyze the chemical components of the essential oil from Epimedium pubescens Maxim.and Epimedium koreanum Nakai. by GC-MS. Methods The essential oil was extracted from two epimediums by steam distillation, the chemical components of the essential oi1 were detected by GC-MS, peaks and their corresponding compounds were identified through database index. Results 76 chief components from two varieties of epimediums were identified, 24 components were noted in both. Conclusion There were some differences in composition and content between the two kinds of epimediums. A scientific basis for the further identification and quality control of the two different species of epimediums was offered in this paper.
Objective To analyze the chemical components of the essential oil from Epimedium pubescens Maxim.and Epimedium koreanum Nakai. by GC-MS. Methods The essential oil was extracted from two epimediums by steam distillation, the chemical components of the essential oi1 were detected by GC-MS, peaks and their corresponding compounds were identified through database index. Results 76 chief components from two varieties of epimediums were identified, 24 components were noted in both. Conclusion There were some differences in composition and content between the two kinds of epimediums. A scientific basis for the further identification and quality control of the two different species of epimediums was offered in this paper.
2011, 29(6): 449-450.
Abstract:
Objective To confirm the effect of gabexate mesylate on eliminating choledocholithiasis. Methods By simple randomization, the patients were assigned control group (not use gabexate), regular dosage group and high dosage group. The difference between every group on effect of eliminating choledocholithiasis by nonsurgical operation was observed. Results No significant different was found between regular dosage group and control group (P>0.05). There was a significant different between regular dosage group and high dosage group (P<0.05). Conclusion Gabexate mesylate had the effect of eliminating choledocholithiasis.
Objective To confirm the effect of gabexate mesylate on eliminating choledocholithiasis. Methods By simple randomization, the patients were assigned control group (not use gabexate), regular dosage group and high dosage group. The difference between every group on effect of eliminating choledocholithiasis by nonsurgical operation was observed. Results No significant different was found between regular dosage group and control group (P>0.05). There was a significant different between regular dosage group and high dosage group (P<0.05). Conclusion Gabexate mesylate had the effect of eliminating choledocholithiasis.
2011, 29(6): 451-452,477.
Abstract:
Objective To classify traditional Chinese medicine and natural medicine preparations commonly used in clinical treatment of coronary heart disease and provide references to choice the reasonable treatment medicines. Methods Documents related books and databases, and reference dispensatory were analyzed and summarized. Results Traditional Chinese herbal formula, Chinese medicine or natural medicine's extract preparations and single-ingredient formulations were quite different in functions and indications. Conclusion Chinese herbs and natural medicines of coronary heart disease should be classified according to function and application. The principles of clinical utility were put forward, which could improve the level of rational drug use.
Objective To classify traditional Chinese medicine and natural medicine preparations commonly used in clinical treatment of coronary heart disease and provide references to choice the reasonable treatment medicines. Methods Documents related books and databases, and reference dispensatory were analyzed and summarized. Results Traditional Chinese herbal formula, Chinese medicine or natural medicine's extract preparations and single-ingredient formulations were quite different in functions and indications. Conclusion Chinese herbs and natural medicines of coronary heart disease should be classified according to function and application. The principles of clinical utility were put forward, which could improve the level of rational drug use.
2011, 29(6): 453-454.
Abstract:
Objective To optimize the synthetic process of bendamustin for high purity. Methods Bendamustin was prepared from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester by reduction,substitution,hydrolization and salification,successively. Results A good process for preparation of bendamustin was successfully achieved with low cost, easy operation and high purity. Conclusion The overall yield of the new process was 62%, which was more suitable for industrial production.
Objective To optimize the synthetic process of bendamustin for high purity. Methods Bendamustin was prepared from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester by reduction,substitution,hydrolization and salification,successively. Results A good process for preparation of bendamustin was successfully achieved with low cost, easy operation and high purity. Conclusion The overall yield of the new process was 62%, which was more suitable for industrial production.
2011, 29(6): 455-456,459.
Abstract:
Objective To explore a convenient and environmentally friendly benign synthesis method of monastrol. Methods Monastrol was synthesized from m-hydroxybenzaldehyde, ethyl acetoacetate and thiourea through the Biginelli reaction catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate under microwave irradiation without a solvent. Results The green room temperature ionic liquid could catalyze the Biginelli reaction to get monsatrol under microwave irradiation without a solvent. The process was easy to operate and was environmentally friendly. Conclusion Microwave accelerated solvent-free Biginelli reaction using 1-butyl-3-methylimidazolium (L)-camphorsulfonate as catalyst, which was a convenient and environmentally benign synthesis method of monastrol.
Objective To explore a convenient and environmentally friendly benign synthesis method of monastrol. Methods Monastrol was synthesized from m-hydroxybenzaldehyde, ethyl acetoacetate and thiourea through the Biginelli reaction catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate under microwave irradiation without a solvent. Results The green room temperature ionic liquid could catalyze the Biginelli reaction to get monsatrol under microwave irradiation without a solvent. The process was easy to operate and was environmentally friendly. Conclusion Microwave accelerated solvent-free Biginelli reaction using 1-butyl-3-methylimidazolium (L)-camphorsulfonate as catalyst, which was a convenient and environmentally benign synthesis method of monastrol.
2011, 29(6): 457-459.
Abstract:
Objective To establish a specific method for determination of forbidden addition drugs of Diazepam,Clonazepan and Estazolam in tranquilizing mind Traditional Chinese Medicine. Methods Diazepam, Clonazepam and Estazolam were determined and analyzed by UPLC-MS/MS. ACQUITY BEH C18 analysis column(2.1 mm×50 mm,1.7 μm) was used with the mobile phase of 10 mmol/L ammonium acetate and acetonitrile(90：10) with gradient elution. The flow rate was 0.4 ml/min,and the detection wavelength was 254 nm.EIS ion source was used with positive ion monitoring. Results The standard curves of Diazepam,Clonazepam and Estazolam showed good linearity over the concentration rang of 109.8~878.4, 102.1~816.8,106.9~855.2 ng/ml,The detection limits were 0.06,2.5×10-3,2.8×10-3 ng,the quantitation limits were 0.19,8.2×10-3,9.2×10-3 ng,the average recoveries of three chemicals was 95.7%~103.7%. Conclution The method was specific,sensitive,easily and quickly,which could be used to detect Diazepam,Clonazepan and Estazolam in tranquilizing mind traditional Chinese medicine.
Objective To establish a specific method for determination of forbidden addition drugs of Diazepam,Clonazepan and Estazolam in tranquilizing mind Traditional Chinese Medicine. Methods Diazepam, Clonazepam and Estazolam were determined and analyzed by UPLC-MS/MS. ACQUITY BEH C18 analysis column(2.1 mm×50 mm,1.7 μm) was used with the mobile phase of 10 mmol/L ammonium acetate and acetonitrile(90：10) with gradient elution. The flow rate was 0.4 ml/min,and the detection wavelength was 254 nm.EIS ion source was used with positive ion monitoring. Results The standard curves of Diazepam,Clonazepam and Estazolam showed good linearity over the concentration rang of 109.8~878.4, 102.1~816.8,106.9~855.2 ng/ml,The detection limits were 0.06,2.5×10-3,2.8×10-3 ng,the quantitation limits were 0.19,8.2×10-3,9.2×10-3 ng,the average recoveries of three chemicals was 95.7%~103.7%. Conclution The method was specific,sensitive,easily and quickly,which could be used to detect Diazepam,Clonazepan and Estazolam in tranquilizing mind traditional Chinese medicine.
2011, 29(6): 460-461.
Abstract:
Objective To establish a RP-HPLC method for determination of chlorogenic acid in wujing capsule. Methods Agilent extend-C18 (4.6 mm×250 mm,5 μm)column was used. The mobile phase was acetonitrile: 0.1%formic acid (8：92). The flow rate was 1.0 ml/min, and the temperature was at 35 ℃. The detection wavelength was 327 nm. Determination of chlorogenic acid in wujin capsule of 5 batches of preparations. Results The calibration curve was at the range of 2.04~102 μg/ml(r=0.999 9), and the average recovery was 104.68 %,and RSD was 1.43%(n=6).5 batches of chlorogenic acid contents in wujin capsule were between 55.08~83.31 μg/g. Conclusion The method was sensitive and accurate, and could be used for the quality control of wujin capsule.
Objective To establish a RP-HPLC method for determination of chlorogenic acid in wujing capsule. Methods Agilent extend-C18 (4.6 mm×250 mm,5 μm)column was used. The mobile phase was acetonitrile: 0.1%formic acid (8：92). The flow rate was 1.0 ml/min, and the temperature was at 35 ℃. The detection wavelength was 327 nm. Determination of chlorogenic acid in wujin capsule of 5 batches of preparations. Results The calibration curve was at the range of 2.04~102 μg/ml(r=0.999 9), and the average recovery was 104.68 %,and RSD was 1.43%(n=6).5 batches of chlorogenic acid contents in wujin capsule were between 55.08~83.31 μg/g. Conclusion The method was sensitive and accurate, and could be used for the quality control of wujin capsule.
2011, 29(6): 462-463,480.
Abstract:
Acid base titration was a common type of volumetric analysis, which was difficult to calculate the pH value of the mixture solution and draw the titration curve. The formulas for percentage of titration (φ ) and concentration of H+ based on the acid base titration theory were derived and programmed by Visual Basic 6.0 software in this study. The titration process was dynamic simulated by calculating the exact pH value and drawing the titration curve.
Acid base titration was a common type of volumetric analysis, which was difficult to calculate the pH value of the mixture solution and draw the titration curve. The formulas for percentage of titration (φ ) and concentration of H+ based on the acid base titration theory were derived and programmed by Visual Basic 6.0 software in this study. The titration process was dynamic simulated by calculating the exact pH value and drawing the titration curve.
2011, 29(6): 464-466.
Abstract:
Objective To explore the application of servqual method in quality assessment of pharmaceutical services for outpatients, and investigate the main problems in the pharmaceutical services. Methods The servqual table was designed, and used as a questionnaire which to investigate the quality of services. One hundred and fifty-seven outpatients in a Grade 3 Level A hospital were investigated. Results Expected service demanded by patients in the reliabity, responsiveness, assurance、 empathy and materiality of servqual table scored 4.55, 4.36, 4.01, 4.18 and 4.31 respectively, and perceived service scored 4.44、4.29、3.79、4.21 and 4.33 respectively. The SQs of materiality and empathy were positive value. The SQs of responsiveness, reliability and assurance were negative value. Conclusion The recruited hospital did a good job in such aspects as materiality, empathy and responsiveness of pharmaceutical services, but reliabity and assurance need to be further improved. The servqual table was an objective and comprehensive method to evaluate the quality of pharmaceutical services which was good for improvement of pharmaceutical services' quality.
Objective To explore the application of servqual method in quality assessment of pharmaceutical services for outpatients, and investigate the main problems in the pharmaceutical services. Methods The servqual table was designed, and used as a questionnaire which to investigate the quality of services. One hundred and fifty-seven outpatients in a Grade 3 Level A hospital were investigated. Results Expected service demanded by patients in the reliabity, responsiveness, assurance、 empathy and materiality of servqual table scored 4.55, 4.36, 4.01, 4.18 and 4.31 respectively, and perceived service scored 4.44、4.29、3.79、4.21 and 4.33 respectively. The SQs of materiality and empathy were positive value. The SQs of responsiveness, reliability and assurance were negative value. Conclusion The recruited hospital did a good job in such aspects as materiality, empathy and responsiveness of pharmaceutical services, but reliabity and assurance need to be further improved. The servqual table was an objective and comprehensive method to evaluate the quality of pharmaceutical services which was good for improvement of pharmaceutical services' quality.
2011, 29(6): 467-469.
Abstract:
To analyze the more specific and stricter requirements of the public for hospital pharmacists under new healthcare reform. The gap between the current situation and realistic requirements of hospital pharmacists was discussed. In addition, a way was suggested to improve the occupational qualities of hospital pharmacists, so that the social requirements for pharmacists could be fulfilled.
To analyze the more specific and stricter requirements of the public for hospital pharmacists under new healthcare reform. The gap between the current situation and realistic requirements of hospital pharmacists was discussed. In addition, a way was suggested to improve the occupational qualities of hospital pharmacists, so that the social requirements for pharmacists could be fulfilled.
2011, 29(6): 470-471,474.
Abstract:
Objective To approach the methods for improving the rate of drugs consistent with the account book, rate of drugs turnover and ensure timely supply of drugs in hospital pharmacy. Methods SO9001 quality management system concept and single-species management were applied to set number of varieties of cargo space. Results and Conclusion The rate of drug consistent with the account book was improved, the amount of inventory of drugs were reduced, and the drug turnover was speed up.
Objective To approach the methods for improving the rate of drugs consistent with the account book, rate of drugs turnover and ensure timely supply of drugs in hospital pharmacy. Methods SO9001 quality management system concept and single-species management were applied to set number of varieties of cargo space. Results and Conclusion The rate of drug consistent with the account book was improved, the amount of inventory of drugs were reduced, and the drug turnover was speed up.
2011, 29(6): 472-474.
Abstract:
Objective To perform a bibliometric analysis of paper published by school of Pharmacy in Second Military Medical University in journals covered by SCIE during 1994~2009,so as to provide evidence for decision making in scientific research administration. Methods The papers published in journals covered by SCIE(Science Citation Index Expanded) authored by researchers of school of Pharmacy in Second Military Medical University in 1994~2009 were retrieved and analyzed. Results 893 papers were retrieved from 893 journals.Original articale accounted for 91%; IF lower than 5 accounted for 83%;There were 24 papers which had been cited for more than 20 times;the most active subject was Pharmacology. Conclusion This study introduces the publication of scientific papers published by school of Pharmacy in Second Military Medical University and their citations from a bibliometric perspective,which provided a quantitative reference for the scientific administration department and the researchers.
Objective To perform a bibliometric analysis of paper published by school of Pharmacy in Second Military Medical University in journals covered by SCIE during 1994~2009,so as to provide evidence for decision making in scientific research administration. Methods The papers published in journals covered by SCIE(Science Citation Index Expanded) authored by researchers of school of Pharmacy in Second Military Medical University in 1994~2009 were retrieved and analyzed. Results 893 papers were retrieved from 893 journals.Original articale accounted for 91%; IF lower than 5 accounted for 83%;There were 24 papers which had been cited for more than 20 times;the most active subject was Pharmacology. Conclusion This study introduces the publication of scientific papers published by school of Pharmacy in Second Military Medical University and their citations from a bibliometric perspective,which provided a quantitative reference for the scientific administration department and the researchers.
2011, 29(6): 475-477.
Abstract:
Objective To investigate economic effects of three kinds of nucleoside analogues in treatment of chronic hepatitis B. Methods 268 cases were divided into three groups, ADV group with adefovir dipivoxil 10mg, ETV group with entecavir 0.5 mg, LdT group with telbivudine 600 mg. All the groups were administered once a day with a course of 48 weeks. Efficacy and adverse reactions were observed. Cost-effectiveness analysis was used. Results ETV group and LdT group were better than ADV group in terms of HBV-DNA negative conversion rate(P<0.01),in HBeAg negative conversion rate and ALT normalization rate, three groups showed no statistically significant differences(P>0.05), The adverse reactions of three groups had no significant difference(P>0.05).The effectiveness ratio of ADV group, ETV group, LdT group was 115.38, 156.51, 96.98 respectively.Telbivudine was superior to adefovir dipivoxil and entecavir in terms of economics. Conclution Telbivudine group was the optimal solution for chronic hepatitis B.
Objective To investigate economic effects of three kinds of nucleoside analogues in treatment of chronic hepatitis B. Methods 268 cases were divided into three groups, ADV group with adefovir dipivoxil 10mg, ETV group with entecavir 0.5 mg, LdT group with telbivudine 600 mg. All the groups were administered once a day with a course of 48 weeks. Efficacy and adverse reactions were observed. Cost-effectiveness analysis was used. Results ETV group and LdT group were better than ADV group in terms of HBV-DNA negative conversion rate(P<0.01),in HBeAg negative conversion rate and ALT normalization rate, three groups showed no statistically significant differences(P>0.05), The adverse reactions of three groups had no significant difference(P>0.05).The effectiveness ratio of ADV group, ETV group, LdT group was 115.38, 156.51, 96.98 respectively.Telbivudine was superior to adefovir dipivoxil and entecavir in terms of economics. Conclution Telbivudine group was the optimal solution for chronic hepatitis B.
2011, 29(6): 478-480.
Abstract:
In order to ensure the safety of drug usage among troops, the Military Drug Control Institute was responsible for all the sampling inspection on military drug and pharmaceutical preparation. However, problems kept coming out during the reform attempts of random testing mode in military. This article was about to discuss several issues related to the quantity of random testing drugs in the Military Drug Control Institute, then the proposals to provide a reference improving the military drugs control were offered.
In order to ensure the safety of drug usage among troops, the Military Drug Control Institute was responsible for all the sampling inspection on military drug and pharmaceutical preparation. However, problems kept coming out during the reform attempts of random testing mode in military. This article was about to discuss several issues related to the quantity of random testing drugs in the Military Drug Control Institute, then the proposals to provide a reference improving the military drugs control were offered.
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