2008 Vol. 26, No. 4
Display Method:
2008, (4): 258-260,296.
Abstract:
Objective: To study the characters of membrane current of types of excitory amino acide and the acting way of TypeⅢmGluR（metabotropic glutamate receptor） agonist—L-SOP among them. Methods: A total receptor RNA was isolated from adult rat brain by acid guanidnium thiocyanate-phenol-chloroform（AGPC） method,mRNA was isolated from the total RNA by oligo（dT）-cellu- cose chromatography,and was then micro-injected into Xenopus oocytes to express,through a two-microeleetrode voltage clamp tech- nique.The ooeytes were refused with varieties of types of excitory amino acid. Results: 100μM KA（kainate） （ionic glutamate recep- tor） induced first a peak current and then a slowly descending current,which desentized at last.The mean maintained time was 37.57 min.2μM QA（quisqualate） （TYPEⅠmGluR） induced regulary calcium oscillation with a maintained time of （6.72±1.33） min. Both of the maintained time were shortened the agonist concentration increased.0.8 mM L-SOP of TYPEⅢmGluR agonist induced a kind of disciplinary oscillation with a maintained time of （20.17±8.47） min which was also shortened with an increasing concentra- tion,while the oscillation coule be antagonized by TYPEⅠmGluR antagonist—L-AP3. Conclusion:: Each of these three types of gluta- mate amino acid receptors has its speuniquecial current mode when irritated;L-SOP is not only an agonist of TYPEⅢmGluR,but also a weak agonist of TYPEⅠ,that is,its acting way of producing oscillation is through TYPEⅠreceptor.
Objective: To study the characters of membrane current of types of excitory amino acide and the acting way of TypeⅢmGluR（metabotropic glutamate receptor） agonist—L-SOP among them. Methods: A total receptor RNA was isolated from adult rat brain by acid guanidnium thiocyanate-phenol-chloroform（AGPC） method,mRNA was isolated from the total RNA by oligo（dT）-cellu- cose chromatography,and was then micro-injected into Xenopus oocytes to express,through a two-microeleetrode voltage clamp tech- nique.The ooeytes were refused with varieties of types of excitory amino acid. Results: 100μM KA（kainate） （ionic glutamate recep- tor） induced first a peak current and then a slowly descending current,which desentized at last.The mean maintained time was 37.57 min.2μM QA（quisqualate） （TYPEⅠmGluR） induced regulary calcium oscillation with a maintained time of （6.72±1.33） min. Both of the maintained time were shortened the agonist concentration increased.0.8 mM L-SOP of TYPEⅢmGluR agonist induced a kind of disciplinary oscillation with a maintained time of （20.17±8.47） min which was also shortened with an increasing concentra- tion,while the oscillation coule be antagonized by TYPEⅠmGluR antagonist—L-AP3. Conclusion:: Each of these three types of gluta- mate amino acid receptors has its speuniquecial current mode when irritated;L-SOP is not only an agonist of TYPEⅢmGluR,but also a weak agonist of TYPEⅠ,that is,its acting way of producing oscillation is through TYPEⅠreceptor.
2008, (4): 261-263,277.
Abstract:
Objective: To optimize the formula and prepare delavirdine mesylate dispersible tablets. Methods: The formula of delavirdine mesylate dispersible tablet was optimized in term of disintegrating time by orthogonal design test.The dissolution rates of the principal agent in dispersible tablets were determined. Results: The optimized dispersible tablets had fine appearance and disintegrated in 3 min,and the suspension screened through the 710μm mesh.The dissolution rates of the dispersible tablets were similar in 3 bat- ches formulation. Conclusion:: The prepared delavirdine mesylate dispersible tablet was reasonable in formula,feasible in technology and was accorded with the quality standards.
Objective: To optimize the formula and prepare delavirdine mesylate dispersible tablets. Methods: The formula of delavirdine mesylate dispersible tablet was optimized in term of disintegrating time by orthogonal design test.The dissolution rates of the principal agent in dispersible tablets were determined. Results: The optimized dispersible tablets had fine appearance and disintegrated in 3 min,and the suspension screened through the 710μm mesh.The dissolution rates of the dispersible tablets were similar in 3 bat- ches formulation. Conclusion:: The prepared delavirdine mesylate dispersible tablet was reasonable in formula,feasible in technology and was accorded with the quality standards.
2008, (4): 267-268,281.
Abstract:
Objective: To study the chemical constituents of Yizhi composite deeoction. Methods: Silica gel column chromatogra- phy was used to isolate and purify the compounds,and the structures were identified on the basis of IR,MS,1H-NMR,13C-NMR and other data. Results: Seven compounds were isolated and identified as emodin （Ⅰ）,physcion （Ⅱ）,chrysophanol （Ⅲ）,panaxadiol （Ⅳ）,panaxatriol （Ⅴ）,β-sitosterol （Ⅵ） and daucosterol （Ⅶ）. Conclusion:: All of the compounds were isolated from Yizhi compos- ite deeoetion for the first time.
Objective: To study the chemical constituents of Yizhi composite deeoction. Methods: Silica gel column chromatogra- phy was used to isolate and purify the compounds,and the structures were identified on the basis of IR,MS,1H-NMR,13C-NMR and other data. Results: Seven compounds were isolated and identified as emodin （Ⅰ）,physcion （Ⅱ）,chrysophanol （Ⅲ）,panaxadiol （Ⅳ）,panaxatriol （Ⅴ）,β-sitosterol （Ⅵ） and daucosterol （Ⅶ）. Conclusion:: All of the compounds were isolated from Yizhi compos- ite deeoetion for the first time.
2008, (4): 269-271.
Abstract:
Objective: To expand new pharmacological resource,traditional plant Crocus sativus L.and to find new pharmacologi- cal active parts to take place of traditional pharmacological part,stigma. Methods: The methods of an abdominal constriction induced by acetic-acid and xylene-induced mice ear edema were used to investigate the analgesic and anti-inflammatory effects of different ex- tracts from Crocus sativus,respectively.Indomethacin and dexamethasone were used as positive control of analgesic and anti-inflamma- tory tests,respectively.The extracts included EtOH extract of corm (CE),apical bud (AE),lateral bud (LE),stigma (SE),the a- queous extract of corm (CA),apical bud (AA),lateral bud (LA),and stigma (SA).Result:In the analgesic tests,compared with negative control,the extracts from apical bud and stigma of ethanol and aqueous ( AE,SE,AA,SA) and lateral bud extract of ethanol at the dose of 2.0 g/kg showed significant (P<0.05 or P<0.01) analgesic activities.On the contrary,CE,CA,LE(at the dose of 0.75 g/kg and 1.5 g/kg),and LA showed no analgesic activities.In the anti-inflammatory tests,SE and LE of Crocus sativus showed significant anti-inflammatory effects compared with negative control.At the dose of 0.75 g/kg,the SE showed significant anti-inflam- matory effects.However,CA,AA,LA,SA and CE had no anti-inflammatory activities in the tests of xylene-induced mice ear edema. Conclusion:: The studies of apical bud and lateral bud of Crocus sativus instead of stigma of Crocus sativus on analgesic and anti-inflam- mation use worth further discussing.
Objective: To expand new pharmacological resource,traditional plant Crocus sativus L.and to find new pharmacologi- cal active parts to take place of traditional pharmacological part,stigma. Methods: The methods of an abdominal constriction induced by acetic-acid and xylene-induced mice ear edema were used to investigate the analgesic and anti-inflammatory effects of different ex- tracts from Crocus sativus,respectively.Indomethacin and dexamethasone were used as positive control of analgesic and anti-inflamma- tory tests,respectively.The extracts included EtOH extract of corm (CE),apical bud (AE),lateral bud (LE),stigma (SE),the a- queous extract of corm (CA),apical bud (AA),lateral bud (LA),and stigma (SA).Result:In the analgesic tests,compared with negative control,the extracts from apical bud and stigma of ethanol and aqueous ( AE,SE,AA,SA) and lateral bud extract of ethanol at the dose of 2.0 g/kg showed significant (P<0.05 or P<0.01) analgesic activities.On the contrary,CE,CA,LE(at the dose of 0.75 g/kg and 1.5 g/kg),and LA showed no analgesic activities.In the anti-inflammatory tests,SE and LE of Crocus sativus showed significant anti-inflammatory effects compared with negative control.At the dose of 0.75 g/kg,the SE showed significant anti-inflam- matory effects.However,CA,AA,LA,SA and CE had no anti-inflammatory activities in the tests of xylene-induced mice ear edema. Conclusion:: The studies of apical bud and lateral bud of Crocus sativus instead of stigma of Crocus sativus on analgesic and anti-inflam- mation use worth further discussing.
2008, (4): 272-273,298.
Abstract:
Objective: To study the effects of acanthopanax senticosus saponins (ASS)on platelet,blood coagulation and blood vis- cosity in rabbits. Methods: Platelet aggregation,APTT (activated partial thromboplastin time),PT (prothrombin time),TT (Thrombin time),blood viscosity,plasma viscosity and hematocrit were measured by mutifunctional intellectual blood coagulation analyzer and self erasure rotary viscometer after rabbit was fed with ASS. Results: ASS significantly inhibited platelet aggregation induced by ADP, and ASS can decrease the blood viscosity significantly.But it had no effect on APT1",PT and I3". Conclusion:: ASS possessed the abili- ty of improving blood viscosity and inhibiting thrombosis.This effect was due to its action on decreasing erythrocyte aggregation and blood stickiness.
Objective: To study the effects of acanthopanax senticosus saponins (ASS)on platelet,blood coagulation and blood vis- cosity in rabbits. Methods: Platelet aggregation,APTT (activated partial thromboplastin time),PT (prothrombin time),TT (Thrombin time),blood viscosity,plasma viscosity and hematocrit were measured by mutifunctional intellectual blood coagulation analyzer and self erasure rotary viscometer after rabbit was fed with ASS. Results: ASS significantly inhibited platelet aggregation induced by ADP, and ASS can decrease the blood viscosity significantly.But it had no effect on APT1",PT and I3". Conclusion:: ASS possessed the abili- ty of improving blood viscosity and inhibiting thrombosis.This effect was due to its action on decreasing erythrocyte aggregation and blood stickiness.
2008, (4): 274-277.
Abstract:
Objective: To study the preparation and purification of silybin meglumine. Methods: IThe procedure of the preparation included two steps:first,the crude silybin was recrgstallized with absolute alcohol,and activated carbon which was used to adsorb im- purity simultaneously.Then,the purificatory product and meglumine were used to preparation silybin meglumine. Results: The content of silybin meglumine in preparation products was higher than 96% detected by ultraviolet spectrometer and 80% detected by high per- formance liquid chromatography (HPLC).The mass rate is approximately 72.1%. Conclusion:: This experiment proved that the pro- duction process of silybin meglumine was stable,each step of operating conditions was easy to control.The product quality was reliable and suitable for industrial production.
Objective: To study the preparation and purification of silybin meglumine. Methods: IThe procedure of the preparation included two steps:first,the crude silybin was recrgstallized with absolute alcohol,and activated carbon which was used to adsorb im- purity simultaneously.Then,the purificatory product and meglumine were used to preparation silybin meglumine. Results: The content of silybin meglumine in preparation products was higher than 96% detected by ultraviolet spectrometer and 80% detected by high per- formance liquid chromatography (HPLC).The mass rate is approximately 72.1%. Conclusion:: This experiment proved that the pro- duction process of silybin meglumine was stable,each step of operating conditions was easy to control.The product quality was reliable and suitable for industrial production.
2008, (4): 278-281.
Abstract:
Objective: To study the antiplatelet aggregative aclivity nf 6-（4-substituted acetamido-phenyl）-4,5-dihydro-3（2H）-py- ridazinones with different heterocylic groups. Methods: Ten target compounds were designed and synthesized.All of them were con- firmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggre- gative activity to a certain extent.Compound （5）,（9） and （10） were better than MCI-154 in vitro. Conclusion:: The stereospecifie blockade and hydrophilieity of different heterocylic groups impacted the antiplatelet aggregative activity.
Objective: To study the antiplatelet aggregative aclivity nf 6-（4-substituted acetamido-phenyl）-4,5-dihydro-3（2H）-py- ridazinones with different heterocylic groups. Methods: Ten target compounds were designed and synthesized.All of them were con- firmed by 1H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggre- gative activity to a certain extent.Compound （5）,（9） and （10） were better than MCI-154 in vitro. Conclusion:: The stereospecifie blockade and hydrophilieity of different heterocylic groups impacted the antiplatelet aggregative activity.
2008, (4): 282-283,307.
Abstract:
Objective: To compare the antidepressant effects of Yukexin capsule and its components on depressive mouse models. Methods: The mice were randomly divided into 5 groups:a control group,a fluoxetine group、a hypericum perforatum group,and the other components.By Using mouse tail suspension test(TST),mouse forced swim test (FST) and reserpine reversal,the antidepres- sant effects of Yukexin capsule and its components were observed.Result:Yukexin capsule shortened the immobility time of tailing suspension and furced swimming of the mice,and could also reverse the ptosis induced by reserpine,hut the symptoms were not notely affected by its components. Conclusion:: hese results suggest that Yukexin capsule,as a complex of active components,can obviously improve all the symptoms of the depressive models through the synergistie actions of the active components in it.
Objective: To compare the antidepressant effects of Yukexin capsule and its components on depressive mouse models. Methods: The mice were randomly divided into 5 groups:a control group,a fluoxetine group、a hypericum perforatum group,and the other components.By Using mouse tail suspension test(TST),mouse forced swim test (FST) and reserpine reversal,the antidepres- sant effects of Yukexin capsule and its components were observed.Result:Yukexin capsule shortened the immobility time of tailing suspension and furced swimming of the mice,and could also reverse the ptosis induced by reserpine,hut the symptoms were not notely affected by its components. Conclusion:: hese results suggest that Yukexin capsule,as a complex of active components,can obviously improve all the symptoms of the depressive models through the synergistie actions of the active components in it.
2008, (4): 286-289.
Abstract:
Objective: To develop an HPLC quantitative method for the determination of vitaminB6,phenobarbital,chlorphena- mine maleate and diazepam in compound benxiaonamin tablets. Methods: The chromatographic conditions include column C18 （150 mm×4.6 mm,4.6μm）;mobile phase A:aeetonitrile-water-triethylamine（100:900:1,contain 0.01 mol/L Sodium Heptane, adjusted to pH 3.5 by acetic aeid）;mobile phase B:aeetonitrile,gradient elution:0～12 min,A:100%～70%,12～20 min,A: 70%.The flow rate was 1 mL/min and monitored at 260 nm. Results: The retention time of vitaminB6,phenobarbilal,chlorphena- mine maleate and diazepam were 4.6 min,10.2 min,12.3 min and 14.3 min respectively.The regress equation for VitaminB6 was y=251.4x+2.403,r=0.999 8,and the linear range was0.1684～2.021μg,phenobarbital y=145.8x+1.612,r=0.9999 and the linear range was 0.510 8～6.130μg;ehlorphenamine maleate y=697.3x-7.252,r=0.999 9,and the linear range was 0.122 8～1.474μg,diazepam y=2767x+17.75,r=0.999 8 and the linear range was 0.049 60～0.595 2μg.The average re- covery of vitaminB6,phenobarbital,chlorphenamine maleate and diazepam were 100.1%,99.4%,99.3% and 100.7%;and RSD were 0.18%,0.13%,0.47% and 0.16% respectively. Conclusion:: The method was sensiteve,time-saving and accurate.
Objective: To develop an HPLC quantitative method for the determination of vitaminB6,phenobarbital,chlorphena- mine maleate and diazepam in compound benxiaonamin tablets. Methods: The chromatographic conditions include column C18 （150 mm×4.6 mm,4.6μm）;mobile phase A:aeetonitrile-water-triethylamine（100:900:1,contain 0.01 mol/L Sodium Heptane, adjusted to pH 3.5 by acetic aeid）;mobile phase B:aeetonitrile,gradient elution:0～12 min,A:100%～70%,12～20 min,A: 70%.The flow rate was 1 mL/min and monitored at 260 nm. Results: The retention time of vitaminB6,phenobarbilal,chlorphena- mine maleate and diazepam were 4.6 min,10.2 min,12.3 min and 14.3 min respectively.The regress equation for VitaminB6 was y=251.4x+2.403,r=0.999 8,and the linear range was0.1684～2.021μg,phenobarbital y=145.8x+1.612,r=0.9999 and the linear range was 0.510 8～6.130μg;ehlorphenamine maleate y=697.3x-7.252,r=0.999 9,and the linear range was 0.122 8～1.474μg,diazepam y=2767x+17.75,r=0.999 8 and the linear range was 0.049 60～0.595 2μg.The average re- covery of vitaminB6,phenobarbital,chlorphenamine maleate and diazepam were 100.1%,99.4%,99.3% and 100.7%;and RSD were 0.18%,0.13%,0.47% and 0.16% respectively. Conclusion:: The method was sensiteve,time-saving and accurate.
2008, (4): 289-290,293.
Abstract:
Objective: To developed a method for determination of chloramphenicol alcoholic solution. Methods: HPLC method was carried out on a ZORBAX 80A Extend-C18 column（4.6 mm×150 mm,5μm） with UV detection at 278 nm.The mobile phase was acetonitrile-0.1% sodium heptanesulfonate（25:75） with a flow rate of 1.0 mL/min.The column temperture was 35℃and the inject volumes was 10μL.The content of chloramphenicol was calculated by external standardization method. Results: There was a good lin- ear relationship for chloramphenicol within the range of 24.74～247.4μg/mL（r=0.999 9）.The average recovery was 99.28% and RSD was 0.27% （n=9）. Conclusion:: TThe method is simple,specific and not interfered by excipients.It is accurate for quality control of chloramphenicol alcoholic solution.
Objective: To developed a method for determination of chloramphenicol alcoholic solution. Methods: HPLC method was carried out on a ZORBAX 80A Extend-C18 column（4.6 mm×150 mm,5μm） with UV detection at 278 nm.The mobile phase was acetonitrile-0.1% sodium heptanesulfonate（25:75） with a flow rate of 1.0 mL/min.The column temperture was 35℃and the inject volumes was 10μL.The content of chloramphenicol was calculated by external standardization method. Results: There was a good lin- ear relationship for chloramphenicol within the range of 24.74～247.4μg/mL（r=0.999 9）.The average recovery was 99.28% and RSD was 0.27% （n=9）. Conclusion:: TThe method is simple,specific and not interfered by excipients.It is accurate for quality control of chloramphenicol alcoholic solution.
2008, (4): 291-293.
Abstract:
Objective: To establish a method for the content determination of NFH in NFH-13-cyclodextrin inclusion compound. Methods: The drug concentration in NFH-β-eyelodextrin inclusion compound was detected at the wavelength of 267 nm by UV spectro- photometry.The free NFH was eluated by eetoaeetate.The enveloped NFH and its entrapment efficiency were detected by UV spectro- photometry. Results: The linear range of NFH was O.01～0.4 mg/mL (r=0.999 5,n=9);the within day RSD and between-day were 0.17% and 1.82% (u=5),respectively.The average recovery was 100.39% (n=9).The entrapment efficiencies of 3 batches of samples were 73.28%,70.37%,74.97%. Conclusion:: The method is simple and reliable,which can be used for the content determi- nation of NFH in NFH-β-cyclodextrin inclusion compound.
Objective: To establish a method for the content determination of NFH in NFH-13-cyclodextrin inclusion compound. Methods: The drug concentration in NFH-β-eyelodextrin inclusion compound was detected at the wavelength of 267 nm by UV spectro- photometry.The free NFH was eluated by eetoaeetate.The enveloped NFH and its entrapment efficiency were detected by UV spectro- photometry. Results: The linear range of NFH was O.01～0.4 mg/mL (r=0.999 5,n=9);the within day RSD and between-day were 0.17% and 1.82% (u=5),respectively.The average recovery was 100.39% (n=9).The entrapment efficiencies of 3 batches of samples were 73.28%,70.37%,74.97%. Conclusion:: The method is simple and reliable,which can be used for the content determi- nation of NFH in NFH-β-cyclodextrin inclusion compound.
2008, (4): 294-296.
Abstract:
Objective: To establish a RP-HPLC method for determining the contents of tetracaine hydrochloride and ephedrine hydrochloride in Fengdima eye drops. Methods: A gradient elution RP-HPLC method was used with a C18column（4.6 mm×250 mm, 5μm）,the mobile phase consisted of 0.05 mol/l,sodium dihydrogen phosphate-acetonitril （9:1,for A pump） and 0.05 mol/L sodi- um dihydrogen phosphate buffer-acetonitril （3:7,for B pump）;the determination wavelength was 218 nm. Results: The determination was not interfered by the exeipient.The linear range of tetracaine hydrochloride was 50.26～753.9μg/mL,r=1.000.The linear range of ephedrine hydrochloride was 51.38～770.7μg/mL,r=0.999 5.The average recovery were 100.25%,99.57% respectively, while RSD were 0.75%,0.91%.respectively. Conclusion:: The contents of tetracaine hydrochloride and ephedrine hydrochloride could be determined effectively at the same time by the proposed method,which is simple,accurate and can he applied for determining the contents of preparation interfered by honey.
Objective: To establish a RP-HPLC method for determining the contents of tetracaine hydrochloride and ephedrine hydrochloride in Fengdima eye drops. Methods: A gradient elution RP-HPLC method was used with a C18column（4.6 mm×250 mm, 5μm）,the mobile phase consisted of 0.05 mol/l,sodium dihydrogen phosphate-acetonitril （9:1,for A pump） and 0.05 mol/L sodi- um dihydrogen phosphate buffer-acetonitril （3:7,for B pump）;the determination wavelength was 218 nm. Results: The determination was not interfered by the exeipient.The linear range of tetracaine hydrochloride was 50.26～753.9μg/mL,r=1.000.The linear range of ephedrine hydrochloride was 51.38～770.7μg/mL,r=0.999 5.The average recovery were 100.25%,99.57% respectively, while RSD were 0.75%,0.91%.respectively. Conclusion:: The contents of tetracaine hydrochloride and ephedrine hydrochloride could be determined effectively at the same time by the proposed method,which is simple,accurate and can he applied for determining the contents of preparation interfered by honey.
2008, (4): 299-301.
Abstract:
Objective: Discuss the challenge and strategy of medical supplies support facing in earthquake relieving from practical and theoretical point of view. Methods: Summarized and analyzed the work of medical supplies support implemented by joint logistic command of Chengdu military area in earthquake relieving after the 5.12 earthquake in Wenchuan,Sichuan province in southwestern China.The main point was to analyze the difficulties and insufficiencies in earthquake relieving.Results and Conclusion:: Communica- tion,report and transportation are the key factors influencing the efficacy of medical supplies support,while changes of need and com- ponent elements of provision are major factors influencing the precision.The platform of medical supplies support of standardizing and informationalizing would help shorten response time and raise efficacy when dealing with emergencies or war significantly.
Objective: Discuss the challenge and strategy of medical supplies support facing in earthquake relieving from practical and theoretical point of view. Methods: Summarized and analyzed the work of medical supplies support implemented by joint logistic command of Chengdu military area in earthquake relieving after the 5.12 earthquake in Wenchuan,Sichuan province in southwestern China.The main point was to analyze the difficulties and insufficiencies in earthquake relieving.Results and Conclusion:: Communica- tion,report and transportation are the key factors influencing the efficacy of medical supplies support,while changes of need and com- ponent elements of provision are major factors influencing the precision.The platform of medical supplies support of standardizing and informationalizing would help shorten response time and raise efficacy when dealing with emergencies or war significantly.
2008, (4): 302-304.
Abstract:
Objective: To upgrade the manage level of medicines in a hospital. Methods: Introduced the constitution,characteris- tics of the hospital outpatient service electron label information system then analyse and discuss about it.Results & Conclusion:: The establishment of electron label system is helpful to the medicines management to become more scientific and standardization.
Objective: To upgrade the manage level of medicines in a hospital. Methods: Introduced the constitution,characteris- tics of the hospital outpatient service electron label information system then analyse and discuss about it.Results & Conclusion:: The establishment of electron label system is helpful to the medicines management to become more scientific and standardization.
2008, (4): 314-315.
Abstract:
Objective: To discuss the technoloqy and qualification of the ultrasonic extracting method of polysaccharide from Ficus hirta Vahl,to provide theories for the super voice of polysaccharide. Methods: Polysaccharides were extraeted with orthogonal experi- ment by ultrasonic method,and the content was determined by spectrophotometry. Results: The optimum technology was to extract by ultrasonic wave for 40 mins,adding 12 folds of water,and crushed to 60 eyes. Conclusion:: This method is easy to operate and extract and able to obtain a high content of polysaceharide.
Objective: To discuss the technoloqy and qualification of the ultrasonic extracting method of polysaccharide from Ficus hirta Vahl,to provide theories for the super voice of polysaccharide. Methods: Polysaccharides were extraeted with orthogonal experi- ment by ultrasonic method,and the content was determined by spectrophotometry. Results: The optimum technology was to extract by ultrasonic wave for 40 mins,adding 12 folds of water,and crushed to 60 eyes. Conclusion:: This method is easy to operate and extract and able to obtain a high content of polysaceharide.
2008, (4): 364-366,301.
Abstract:
Objective: To prepare aspirin floating tablets which used the oyster shell powder and sodium carboxymethyl cellulose (CMC) as compound drug carrier,end investigate its release characteristics and floating property in vitro. Methods: The drug release was detected in vitro by UV spectrometry.According to the cumulative release curve,the mathematical models for the release process of each group of aspirin floating tablets were studied.And how the dosage of the oyster shell powder and sodium carboxymethyl cellulose influenced the release process was investigated. Results: The second prescription had satisfactory floating property and ideal release process in vitro,and its process accorded with zero-order kinetics process of the medicine characteristic.The simulation equation was Q =0.080 4 t+0.146 2 with the R (correlation coefficient)=0.998 7. Conclusion:: Aspirin floating tablets were prepared and the drug release equation and release pattern was established.
Objective: To prepare aspirin floating tablets which used the oyster shell powder and sodium carboxymethyl cellulose (CMC) as compound drug carrier,end investigate its release characteristics and floating property in vitro. Methods: The drug release was detected in vitro by UV spectrometry.According to the cumulative release curve,the mathematical models for the release process of each group of aspirin floating tablets were studied.And how the dosage of the oyster shell powder and sodium carboxymethyl cellulose influenced the release process was investigated. Results: The second prescription had satisfactory floating property and ideal release process in vitro,and its process accorded with zero-order kinetics process of the medicine characteristic.The simulation equation was Q =0.080 4 t+0.146 2 with the R (correlation coefficient)=0.998 7. Conclusion:: Aspirin floating tablets were prepared and the drug release equation and release pattern was established.
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