2007 Vol. 25, No. 3
Display Method:
2007, (3): 143-144,149.
Abstract:
Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.
Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.
2007, (3): 145-146.
Abstract:
Objective:To find good route of synthesizing methano[C60]fullerene carboxylic acid by using bromoactate for preparing some valuable fullerene derivatives.Methods:Using bromoactate as starting material, ylide was prepared. Ylide and fullerene were used to produce the methano[C60] fullerene carboxylate and hydrolyze it.Results and Conclusion: The intermediate and ultimate products synthesized can be confirmed as the objective by NMR and IR, the method is feasible and economical.
Objective:To find good route of synthesizing methano[C60]fullerene carboxylic acid by using bromoactate for preparing some valuable fullerene derivatives.Methods:Using bromoactate as starting material, ylide was prepared. Ylide and fullerene were used to produce the methano[C60] fullerene carboxylate and hydrolyze it.Results and Conclusion: The intermediate and ultimate products synthesized can be confirmed as the objective by NMR and IR, the method is feasible and economical.
2007, (3): 147-149.
Abstract:
Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.
Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.
2007, (3): 150-151,183.
Abstract:
Objective: To study the chemical components from dried leaves of Typha angustifolia L. and to find out the active constituents of the plant. Methods: Modern chromatography was used to isolate chemical components and the compounds isolated from Typha angustifolia L. were identified by spectral methods. Results: Six compounds were isolated and identified as quercetin-3,3′-dimethyl ether-4′-O-β-D-glucoside(Ⅰ), 5,7-dihydroxy-3′-methoxy-flovnoids-4′-O-β-D-glucoside (Ⅱ), quercetin-3,3′-dimethyl ether (Ⅲ), hexacosanoic acid (Ⅳ), -sitosterol (Ⅴ), -sitosterol-3-O-β-D-glucopyranoside(Ⅵ), Conclusion: CompoundⅠ,Ⅱand Ⅳ were isolated from the leaves of the plant for the first time.
Objective: To study the chemical components from dried leaves of Typha angustifolia L. and to find out the active constituents of the plant. Methods: Modern chromatography was used to isolate chemical components and the compounds isolated from Typha angustifolia L. were identified by spectral methods. Results: Six compounds were isolated and identified as quercetin-3,3′-dimethyl ether-4′-O-β-D-glucoside(Ⅰ), 5,7-dihydroxy-3′-methoxy-flovnoids-4′-O-β-D-glucoside (Ⅱ), quercetin-3,3′-dimethyl ether (Ⅲ), hexacosanoic acid (Ⅳ), -sitosterol (Ⅴ), -sitosterol-3-O-β-D-glucopyranoside(Ⅵ), Conclusion: CompoundⅠ,Ⅱand Ⅳ were isolated from the leaves of the plant for the first time.
2007, (3): 154-156.
Abstract:
Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.
Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.
2007, (3): 159-161.
Abstract:
Objective:To establish a reversed-phase high performance liquid chromatography method for rotenone in Derris elliptica.Methods:The determination was performed on ZORBAX Eclipse XDB-C18 (5 μm,4.6×150 mm)column. The mobile phase consisted of acetonitrile and 0.1% phosphate acid solution(4852,v/v,pH 2.6)with flow rate at 1.0 mL/min and determination wavelength at 299 nm under 40.0 ℃.Results:Under the conditions described, the calibration curve of rotenone was linear over the concentration range of 30 to 50 mg/L. The regression equation was: A=20.731 1C-0.361 6, r=0.999 8(n=5,P<0.01). The average recovery for rotenone was 100.74%. The mean relative standard deviation(RSD) was 0.86%.Conclusion:The method is simple and accurate, and suitable for the determination of rotenone in Derris elliptica.
Objective:To establish a reversed-phase high performance liquid chromatography method for rotenone in Derris elliptica.Methods:The determination was performed on ZORBAX Eclipse XDB-C18 (5 μm,4.6×150 mm)column. The mobile phase consisted of acetonitrile and 0.1% phosphate acid solution(4852,v/v,pH 2.6)with flow rate at 1.0 mL/min and determination wavelength at 299 nm under 40.0 ℃.Results:Under the conditions described, the calibration curve of rotenone was linear over the concentration range of 30 to 50 mg/L. The regression equation was: A=20.731 1C-0.361 6, r=0.999 8(n=5,P<0.01). The average recovery for rotenone was 100.74%. The mean relative standard deviation(RSD) was 0.86%.Conclusion:The method is simple and accurate, and suitable for the determination of rotenone in Derris elliptica.
2007, (3): 162-164.
Abstract:
Objective: To establish nonaqueous RP-HPLC to determine retinol palmitate、colecalciferol and vitamin E acetate in multi-vitamin injection simultaneously. Methods: The fat vitamins were extracted by SPE; The determination was performed on Warters C18 column (150×4.6 mm, 5.0 μm) with the mobile phase of acetonitrile-methanol-dichloromethane(702010),at a flow rate of 1.0 mL/min and the detection wavelength of 265 nm.Results: In the linear range the correlation coefficients were all 0.999 9.The average recoveries of retinol palmitate、colecalciferol and vitamin E acetate were 99.1%, 100.6% and 99.2%, RSDwere 0.19%, 0.79% and 0.52%.Conclusion:The method is simple and rapid, suitable for the analysis of retinol palmitate,Colecalciferol and vitamin E acetate in multi-vitamin injection.
Objective: To establish nonaqueous RP-HPLC to determine retinol palmitate、colecalciferol and vitamin E acetate in multi-vitamin injection simultaneously. Methods: The fat vitamins were extracted by SPE; The determination was performed on Warters C18 column (150×4.6 mm, 5.0 μm) with the mobile phase of acetonitrile-methanol-dichloromethane(702010),at a flow rate of 1.0 mL/min and the detection wavelength of 265 nm.Results: In the linear range the correlation coefficients were all 0.999 9.The average recoveries of retinol palmitate、colecalciferol and vitamin E acetate were 99.1%, 100.6% and 99.2%, RSDwere 0.19%, 0.79% and 0.52%.Conclusion:The method is simple and rapid, suitable for the analysis of retinol palmitate,Colecalciferol and vitamin E acetate in multi-vitamin injection.
2007, (3): 170-173.
Abstract:
Objective: To demonstrate a new concept of hospital pharmacy information system. Methods: By looking into the development history of hospital information system and the demands of an Internet era and incorporating changes in hospital pharmacy and its requirements. Results: It is found out that the traditional management information system will face the risk of being eliminated due to business reengeneering and rapid academic transformation. If efforts are made to preserve the concepts and models of traditional local business and management information systems, the development objectives of hospital pharmacy will be narrowed and simplified, and the transformation towards patient-oriented pharmaceutical care will not be facilitated. Conclusion: The necessity of building a late-model hospital pharmacy information system is suggested in order to adapt the discipline and society′s fast development.
Objective: To demonstrate a new concept of hospital pharmacy information system. Methods: By looking into the development history of hospital information system and the demands of an Internet era and incorporating changes in hospital pharmacy and its requirements. Results: It is found out that the traditional management information system will face the risk of being eliminated due to business reengeneering and rapid academic transformation. If efforts are made to preserve the concepts and models of traditional local business and management information systems, the development objectives of hospital pharmacy will be narrowed and simplified, and the transformation towards patient-oriented pharmaceutical care will not be facilitated. Conclusion: The necessity of building a late-model hospital pharmacy information system is suggested in order to adapt the discipline and society′s fast development.
2007, (3): 181-183.
Abstract:
Objective:To evaluate the clinical use of vancomycins in our hospital.Methods:The retrospective survey on vancomycins in 237 inpatiens (253 prescriptions!) in 2005 was conducted according to The guiding principle of clinical use of antibacterials.Results:79 cases (31.23% of the orders) met the criteria of the therapeutic indication and 216 cases (85.38% of orders) met the criteria of dosage and administration.Conclusion:The measures,such as restricting the indications and decreasing empirical application will be helpful in promoting the rational use of the agents.
Objective:To evaluate the clinical use of vancomycins in our hospital.Methods:The retrospective survey on vancomycins in 237 inpatiens (253 prescriptions!) in 2005 was conducted according to The guiding principle of clinical use of antibacterials.Results:79 cases (31.23% of the orders) met the criteria of the therapeutic indication and 216 cases (85.38% of orders) met the criteria of dosage and administration.Conclusion:The measures,such as restricting the indications and decreasing empirical application will be helpful in promoting the rational use of the agents.
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