2006 Vol. 24, No. 3
Display Method:
2006, (3): 142-144.
Abstract:
Objective : To construct pseudo-ternary phase diagrams of liquid crystal (LC) with lecithin of various purity and various ratio of lecithin to alcohol (Km). Methods : LC was prepared with lecithin of various purity as surfactant, isopropyl myristate as oil phase and anhydrous alcohol as co-surfactant. The LC configuration was determined with self-made polarization microscope. Results : The liquid crystal formation region was observed light with the polarization microscope. No liquid crystal appeared when the Km was 1 : 4, and in the same condition of 25℃ and Km, the liquid crystal formation region was larger with the lecithin purity increasing. At the same time, the changeable region of water proportion was also larger with the Km increasing. Conclusion : Constructing pseudo-ternary phase diagrams to discribe the factors of liquid crystal configuration is precise and simple.
Objective : To construct pseudo-ternary phase diagrams of liquid crystal (LC) with lecithin of various purity and various ratio of lecithin to alcohol (Km). Methods : LC was prepared with lecithin of various purity as surfactant, isopropyl myristate as oil phase and anhydrous alcohol as co-surfactant. The LC configuration was determined with self-made polarization microscope. Results : The liquid crystal formation region was observed light with the polarization microscope. No liquid crystal appeared when the Km was 1 : 4, and in the same condition of 25℃ and Km, the liquid crystal formation region was larger with the lecithin purity increasing. At the same time, the changeable region of water proportion was also larger with the Km increasing. Conclusion : Constructing pseudo-ternary phase diagrams to discribe the factors of liquid crystal configuration is precise and simple.
2006, (3): 144-146.
Abstract:
Objective :To offer the evidence for reasonable dosage regimen by the pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections. Methods :The cefprozil concentration in plasma was determined by the high performance liquid chromatography method. The pharmacokinetic parameters were obtained by using 3P97 imitate program. Results :With oral multiple - dose of 500mg of cefprozil twice over 5 consecutive days, the main pharmacokinetic parameters obtained from the patients were as follows :t1/2 was (1.55±0.17)h,MRT was (2.52 ±0. 15)h.Cmax was ( 13.32 ± 1. 28)μg/mL,tmax was (1.41±0.31)h,AUC0-10 was (31.68 ±7.68)μg·h/mL. Conclusions :Cefprozil 500mg, bid orally may be effective against low respiratory tract bacterial infections.
Objective :To offer the evidence for reasonable dosage regimen by the pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections. Methods :The cefprozil concentration in plasma was determined by the high performance liquid chromatography method. The pharmacokinetic parameters were obtained by using 3P97 imitate program. Results :With oral multiple - dose of 500mg of cefprozil twice over 5 consecutive days, the main pharmacokinetic parameters obtained from the patients were as follows :t1/2 was (1.55±0.17)h,MRT was (2.52 ±0. 15)h.Cmax was ( 13.32 ± 1. 28)μg/mL,tmax was (1.41±0.31)h,AUC0-10 was (31.68 ±7.68)μg·h/mL. Conclusions :Cefprozil 500mg, bid orally may be effective against low respiratory tract bacterial infections.
2006, (3): 147-149.
Abstract:
Objective : To explore the mechanism of therapeutic effect of matrine on human gastric carcinoma by inhibiting the production of matrix metallo-proleinases of cell line MKN - 45 induced by it. Methods : The production of matrix metalloproteinases (MMP -2,MMP -9)of MKN -45 cells were measured by ELISA and gelatin zymogrmn. Results : In the dose of 5 -20μmol/L, matrine can significantly inhibit MMP-2 as well as MMP-9 expressions in MKN -45 cells. Especially, in the zymographic analysis of MMPs pxressions in conditional culture media, matrine 20μmol/L can greatly inhibit the MMP -2 and MMP -9 enzyme activity. Conclusion : Matrine could significantly inhibit the production and activity of MMPs in gastric carcinoma cell line MKN -45, which showed the inhibitory effect on the metastasis of gastric carcinoma cells.
Objective : To explore the mechanism of therapeutic effect of matrine on human gastric carcinoma by inhibiting the production of matrix metallo-proleinases of cell line MKN - 45 induced by it. Methods : The production of matrix metalloproteinases (MMP -2,MMP -9)of MKN -45 cells were measured by ELISA and gelatin zymogrmn. Results : In the dose of 5 -20μmol/L, matrine can significantly inhibit MMP-2 as well as MMP-9 expressions in MKN -45 cells. Especially, in the zymographic analysis of MMPs pxressions in conditional culture media, matrine 20μmol/L can greatly inhibit the MMP -2 and MMP -9 enzyme activity. Conclusion : Matrine could significantly inhibit the production and activity of MMPs in gastric carcinoma cell line MKN -45, which showed the inhibitory effect on the metastasis of gastric carcinoma cells.
2006, (3): 149-152.
Abstract:
Objective : To study antioxidalion effect of ethanol and aqueous extracts of Broussonetia paperifera fruits from 10 different habitats and assess their qualities by standards of China Pharmacopeia. Methods : MDA production in rats liver homogenate induced by auto-oxidation was measured by MDA kits method and the contents of ashes, elhanol and aqueous extracts were detected. Results : Antioxidation potential of Broussonetia paperifera fruits from Anhui, Shanxi and Cuangxi were significant and contents of ashes were lower from Shandong, Zhejiang and Guangdong than other places. Conclusion : Extracts of Broussonetia paperifera fruits have an-tioxidation effect in vitro, and we suggest that contents of extracts of Broussonetia paperifera fruits be included in next CHP.
Objective : To study antioxidalion effect of ethanol and aqueous extracts of Broussonetia paperifera fruits from 10 different habitats and assess their qualities by standards of China Pharmacopeia. Methods : MDA production in rats liver homogenate induced by auto-oxidation was measured by MDA kits method and the contents of ashes, elhanol and aqueous extracts were detected. Results : Antioxidation potential of Broussonetia paperifera fruits from Anhui, Shanxi and Cuangxi were significant and contents of ashes were lower from Shandong, Zhejiang and Guangdong than other places. Conclusion : Extracts of Broussonetia paperifera fruits have an-tioxidation effect in vitro, and we suggest that contents of extracts of Broussonetia paperifera fruits be included in next CHP.
2006, (3): 152-154.
Abstract:
Objective : To construct the forecasting system of limit test for convolution spectrum method. Methods : Two methods were used to forecast the limit of detection. Results : The results from forecasting method were in consistent with those from experiment in two mixture systems. Conclusion : The forecasting system of limit test is quick and simple to handle, and favours the methods comparison and selection.
Objective : To construct the forecasting system of limit test for convolution spectrum method. Methods : Two methods were used to forecast the limit of detection. Results : The results from forecasting method were in consistent with those from experiment in two mixture systems. Conclusion : The forecasting system of limit test is quick and simple to handle, and favours the methods comparison and selection.
2006, (3): 153-155,166.
Abstract:
Objective :To optimize the formulation of the oral disintegrating tablets of trifluoperazine hydrochloride and compare its dissolution profiles with the marketing tablets. Methods : Orthogonal design was used to optimize the formulation of the tablets. The basket method was used to evaluate the dissolution profiles of the tablets. The content of trifluoperazine hydrochloride in the samples was analyzed by UV. Results : When the ratio of gelatia/mannitol/aspartame/trifluoperazine hydrochloride was 0. 15/1/0. 05/0. 16, the tablets has good mouth feel. When the content of crospovidone, L-HPC and microcrystalline cellulose were set at 8%, 5% and 30%, respectively, the disintegration time was within 15s. The cumulative dissolution of the tablets was more than 90% within 5 minute, respectively. Conclusion : The oral disintegrating tablets of trifluoperazine hydrochloride had the advantage of easy administratio-nand its dissolution was significantly higher than that of the market tablets.
Objective :To optimize the formulation of the oral disintegrating tablets of trifluoperazine hydrochloride and compare its dissolution profiles with the marketing tablets. Methods : Orthogonal design was used to optimize the formulation of the tablets. The basket method was used to evaluate the dissolution profiles of the tablets. The content of trifluoperazine hydrochloride in the samples was analyzed by UV. Results : When the ratio of gelatia/mannitol/aspartame/trifluoperazine hydrochloride was 0. 15/1/0. 05/0. 16, the tablets has good mouth feel. When the content of crospovidone, L-HPC and microcrystalline cellulose were set at 8%, 5% and 30%, respectively, the disintegration time was within 15s. The cumulative dissolution of the tablets was more than 90% within 5 minute, respectively. Conclusion : The oral disintegrating tablets of trifluoperazine hydrochloride had the advantage of easy administratio-nand its dissolution was significantly higher than that of the market tablets.
Analysis of clinical curative effects of cefetamet pivoxil on acute urinary system infected patients
2006, (3): 161-163.
Abstract:
Objective : To analyze the clinical curative effects of cefetamet pivoxil on acute urinary system infected patients. Methods :20 acute urinary system infected patients were randomly divided into two groups: group A(n= 10), in which the patients were treated with cefetamet pivoxil(250mg, po, bid, pc) for 7 days, and group B(n= 10), in which the patients were administrated with amoxicillin-clavulante (375mg, po, tid, pc) for7days. The clinical effective rate, recovery rate and WBC clearance rate in urine were statistically evaluated. Results : The clinical effective rates of group A and group B were 80% and 90%, respectively. The recovery rates of group A and group B were 70% and 80%, respectively. The WBC clearance rates in urine of group A and group B were 70% and 80%, respectively. One side effect case occurred in group B. There was no significant difference statistically between two groups (P > 0.05). Conclusion : Cefetamet Pivoxil is efficient to treat acute urinary tract infection.
Objective : To analyze the clinical curative effects of cefetamet pivoxil on acute urinary system infected patients. Methods :20 acute urinary system infected patients were randomly divided into two groups: group A(n= 10), in which the patients were treated with cefetamet pivoxil(250mg, po, bid, pc) for 7 days, and group B(n= 10), in which the patients were administrated with amoxicillin-clavulante (375mg, po, tid, pc) for7days. The clinical effective rate, recovery rate and WBC clearance rate in urine were statistically evaluated. Results : The clinical effective rates of group A and group B were 80% and 90%, respectively. The recovery rates of group A and group B were 70% and 80%, respectively. The WBC clearance rates in urine of group A and group B were 70% and 80%, respectively. One side effect case occurred in group B. There was no significant difference statistically between two groups (P > 0.05). Conclusion : Cefetamet Pivoxil is efficient to treat acute urinary tract infection.
2006, (3): 164-166.
Abstract:
Objective :To establish a HPLC method for determination of puerarin in radix puerariae dripping pills. Methods :The radix puerariae dripping pills were dissolved with 30% alcohol by ultrasonic wave. The puerarin was separated by Kromasil C18 analysis column. The mobile phase was composed of acetonltrile : water = 10 : 90( V/V). The flow rate of mobile phase was 1mL/min. The detection wavelength was UV 250nm. Results :There was a good linearity from 10 μg/mL to 200 μg/mL (r=0.999 8) in separation of puerarin. The average recovery was 100. 76% and the relative standard deviation 1. 12% (n=6). Conclusion :The method is simple and fast, and the results are reliale.
Objective :To establish a HPLC method for determination of puerarin in radix puerariae dripping pills. Methods :The radix puerariae dripping pills were dissolved with 30% alcohol by ultrasonic wave. The puerarin was separated by Kromasil C18 analysis column. The mobile phase was composed of acetonltrile : water = 10 : 90( V/V). The flow rate of mobile phase was 1mL/min. The detection wavelength was UV 250nm. Results :There was a good linearity from 10 μg/mL to 200 μg/mL (r=0.999 8) in separation of puerarin. The average recovery was 100. 76% and the relative standard deviation 1. 12% (n=6). Conclusion :The method is simple and fast, and the results are reliale.
2006, (3): 170-172.
Abstract:
Objective : To study the application of the inventory control technology of logistic in hospital drug inventory management. Methods : ABC analysis and additional supply rule were used to manage the hospital drug inventory. Results : The combination of ABC analysis and additional supply rule can reduce the drug stocks and increase the turnover rate. The abnormal condition of drug inventory also can be controlled at the same time. Conclusion :The application of the inventory control technology of logistic can reduce the cost of stock management and enhance the efficiency.
Objective : To study the application of the inventory control technology of logistic in hospital drug inventory management. Methods : ABC analysis and additional supply rule were used to manage the hospital drug inventory. Results : The combination of ABC analysis and additional supply rule can reduce the drug stocks and increase the turnover rate. The abnormal condition of drug inventory also can be controlled at the same time. Conclusion :The application of the inventory control technology of logistic can reduce the cost of stock management and enhance the efficiency.
2006, (3): 183-184,186.
Abstract:
Objective : To investigate the situation of adverse drug reactions (ADRs) occurred and the harm to patients. Methods : 79 cases of ADRs collected from Jan 2003 to May 2005 in our hospital were classified, analysis and evaluated. Results : 52 kinds of drug caused ADRs, of which anti-infective agents occupied the first place. The intravenous medication was the main route of medication resulting from ADRs. The main types of ADRs were skin damage. 11 cases had severe ADRs( 13.9% ) . Conclusion : More attention should be paid to monitoring clinical ADRs .
Objective : To investigate the situation of adverse drug reactions (ADRs) occurred and the harm to patients. Methods : 79 cases of ADRs collected from Jan 2003 to May 2005 in our hospital were classified, analysis and evaluated. Results : 52 kinds of drug caused ADRs, of which anti-infective agents occupied the first place. The intravenous medication was the main route of medication resulting from ADRs. The main types of ADRs were skin damage. 11 cases had severe ADRs( 13.9% ) . Conclusion : More attention should be paid to monitoring clinical ADRs .
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