1999 Vol. 17, No. 6
Display Method:
1999, (6): 323-326.
Abstract:
OBJECTIVE To test the efficacy and safety of nimesulide in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) of knee. METHODS: 59 RA patients and 44 OA patients as defined by the American College of Rheumatology criteria were treated with oral nimesulide tablet 100 mg twice daily or ibuprofen 300 mg sustained release capsule twice daily for four weeks. RESULTS In patients with RA, VAS value, pain, Ritchie joint index, grip strength of hands, and morning stiffness improved significantly after treatment. In patients with OA of knee, overall pain, pain on movement, walking time, global efficacy and quality of life scores showed good levels of improvement compared with baseline. In 83.3% of RA patients and 75.0% of OA patients, nimesulide was effective. The frequent events reported were gastrointestinal disorders, occurring in 9.6% of nimesulide patients. The total incidence of adverse reactions was 19.2% in nimesulide patients. There were no significant differences in efficacy and safety between the treatment groups. CONCLUSION The efficacy and safety of nimesulide are equivalent to those of ibuprofen.
OBJECTIVE To test the efficacy and safety of nimesulide in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) of knee. METHODS: 59 RA patients and 44 OA patients as defined by the American College of Rheumatology criteria were treated with oral nimesulide tablet 100 mg twice daily or ibuprofen 300 mg sustained release capsule twice daily for four weeks. RESULTS In patients with RA, VAS value, pain, Ritchie joint index, grip strength of hands, and morning stiffness improved significantly after treatment. In patients with OA of knee, overall pain, pain on movement, walking time, global efficacy and quality of life scores showed good levels of improvement compared with baseline. In 83.3% of RA patients and 75.0% of OA patients, nimesulide was effective. The frequent events reported were gastrointestinal disorders, occurring in 9.6% of nimesulide patients. The total incidence of adverse reactions was 19.2% in nimesulide patients. There were no significant differences in efficacy and safety between the treatment groups. CONCLUSION The efficacy and safety of nimesulide are equivalent to those of ibuprofen.
1999, (6): 339-341.
Abstract:
OBJECTIVE The vitro release of diflunisal capsules were compared with the tablets (imported,made by Merck Corporation). METHODS Referring to the USP ⅩⅩⅢ,the dissolution and the content of two kinds of dosage forms containing diflunisal were determined by UV spectropholometer respectively. RESULTS The average recovery was 100.27%(RSD =0.62%).The in vitro release of capsules was faster that of diflunisal material and available tablets. T80 of capsules was 12.8min vs.13.08min of tablets. CONCLUSION The rate of dissolution has no significance differences between the capsules and the imported tablets.
OBJECTIVE The vitro release of diflunisal capsules were compared with the tablets (imported,made by Merck Corporation). METHODS Referring to the USP ⅩⅩⅢ,the dissolution and the content of two kinds of dosage forms containing diflunisal were determined by UV spectropholometer respectively. RESULTS The average recovery was 100.27%(RSD =0.62%).The in vitro release of capsules was faster that of diflunisal material and available tablets. T80 of capsules was 12.8min vs.13.08min of tablets. CONCLUSION The rate of dissolution has no significance differences between the capsules and the imported tablets.
1999, (6): 349-351.
Abstract:
OBJECTIVE To study the synthetic method and technology of fleroxacin material for injection. METHODS This compound was synthesized using 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-ethylcarbonate as material. RESULTS The element analysis,IR,MS and HNMR of synthetic product were comformable to literature,the total yield was 56.3%.The product was identified,its quality accords with injection′s demands. CONCLUSION Fleroxacin material of this technology synthesized accords with injection′s demands,and it can be used for injection′s production.
OBJECTIVE To study the synthetic method and technology of fleroxacin material for injection. METHODS This compound was synthesized using 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-ethylcarbonate as material. RESULTS The element analysis,IR,MS and HNMR of synthetic product were comformable to literature,the total yield was 56.3%.The product was identified,its quality accords with injection′s demands. CONCLUSION Fleroxacin material of this technology synthesized accords with injection′s demands,and it can be used for injection′s production.
1999, (6): 352-354.
Abstract:
OBJECTIVE To study the separation of mimic-mixed 7 kinds of antraquinone derivatives. METHODS Micellar electrokinetic capillary chromatography with additive of organic solvent was used. RESULTS Emodin,chrysophanl,physcion,rhein,emodin-8-o-β-D-glucopyranoside,aloe-emodin,and Physcion-8-o-β-glucopyranoside were separated successfully in 16 min in the buffer of 25 mmol/L H 3BO 3(pH9.2)containing 25mmol/L SDS and 10% acetonitrile. CONCLUSION Micellar electrokinetic capillary chromatography with additive of organic solvent has potential advantages on separation of anthraquinone derivatives.
OBJECTIVE To study the separation of mimic-mixed 7 kinds of antraquinone derivatives. METHODS Micellar electrokinetic capillary chromatography with additive of organic solvent was used. RESULTS Emodin,chrysophanl,physcion,rhein,emodin-8-o-β-D-glucopyranoside,aloe-emodin,and Physcion-8-o-β-glucopyranoside were separated successfully in 16 min in the buffer of 25 mmol/L H 3BO 3(pH9.2)containing 25mmol/L SDS and 10% acetonitrile. CONCLUSION Micellar electrokinetic capillary chromatography with additive of organic solvent has potential advantages on separation of anthraquinone derivatives.
1999, (6): 356-358,364.
Abstract:
This paper compared different extracting and determine methods of ginkgolides,summarized brief pharmacological action and summed up the study and development of the preparation of Ginkgo biloba L.
This paper compared different extracting and determine methods of ginkgolides,summarized brief pharmacological action and summed up the study and development of the preparation of Ginkgo biloba L.
1999, (6): 370-373.
Abstract:
OBJECTIVE To investigate the use of antibiotics in our hospital with analyzing the prescription. METHODS The prescriptions during 1997～1998 were statistically analyzed. RESULTS The total amount of the prescriptions was 119 395,the prescriptions of antibiotics was 28 498,the percentage was 23.87.There were 47 kinds of antibiotics been used.The first three kinds of antibiotics used were norfloxacin(20.99%),erytromycin(16.85%)and metronidazole(11.99%). CONCLLUSION The antibiotics used in our hospital is almost reasonable,but there still have some problem.
OBJECTIVE To investigate the use of antibiotics in our hospital with analyzing the prescription. METHODS The prescriptions during 1997～1998 were statistically analyzed. RESULTS The total amount of the prescriptions was 119 395,the prescriptions of antibiotics was 28 498,the percentage was 23.87.There were 47 kinds of antibiotics been used.The first three kinds of antibiotics used were norfloxacin(20.99%),erytromycin(16.85%)and metronidazole(11.99%). CONCLLUSION The antibiotics used in our hospital is almost reasonable,but there still have some problem.
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