玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

钱俞君; 秦春霞; 孙莉莉; 丁华敏; 李医明; 李铁军

doi:10.3969/j.issn.1006-0111.2017.03.018

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玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

钱俞君, 秦春霞, 孙莉莉, 丁华敏, 李医明, 李铁军

文章导航 > 药学实践与服务 > 2017 > 35(3): 267-269

钱俞君, 秦春霞, 孙莉莉, 丁华敏, 李医明, 李铁军. 玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察[J]. 药学实践与服务, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018

引用本文:

QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun. Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018

Citation:

QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun. Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018

玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

doi: 10.3969/j.issn.1006-0111.2017.03.018

1.
上海市浦东新区浦南医院药剂科, 上海 200125
2.
上海市中医药大学中药学院, 上海 201210

基金项目: 浦东新区中医药事业发展专项资金"院内制剂和经验方规范化临床验证"项目（PDYNZJ2015-09）

Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure

1.
Department of Pharmacy, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China
2.
Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China

摘要: 目的临床观察玄参配方颗粒联合福辛普利治疗充血性心力衰竭（CHF）的疗效。方法 60例充血性心力衰竭患者，随机分为治疗组30例和对照组30例。在常规治疗基础上，对照组给予福辛普利的治疗，治疗组给予玄参配方颗粒联合福辛普利，疗程均为90 d，评价临床疗效，测定治疗前后左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数（LVEF）和血清B型脑钠肽（BNP）的浓度。结果治疗组和对照组的总有效率均为90%，但治疗组的显效例数大于对照组。与治疗前比较，治疗组和对照组的BNP、LVEDD和LVESD均显著降低，LVEF显著增加，差异均具有统计学意义（P<0.01）。治疗组改善心功能的程度优于对照组（P<0.05）。结论玄参配方颗粒联合福辛普利治疗CHF有明显疗效。
- 充血性心力衰竭 /
- 玄参 /
- 福辛普利 /
- 脑钠肽
Abstract: Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure. Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatment group and 30 patients in the control group. Besides the conventional therapy, the control group was treated with fosinopril and the treatment group received Scrophularia ningpoensis granules plus fosinopril for 90 days. Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and serum B-type brain natriuretic peptide (BNP) were measured before and after treatment. Results The total effective rate in the treatment group and the control group were 90%, but significantly effective number in the treatment group was higher than the control group. The levels of BNP, LVEDD and LVESD in both groups were decreased, while LVEF was increased after the treatment. The difference was statistically significant (P<0.01). The degree of improvement of heart function in the treatment group was better than that in the control group (P<0.05). Conclusion The combination therapy of Scrophularia ningpoensis granules and fosinopril is efficacious in treating CHF.
- congestive heart failure /
- Scrophularia ningpoensis /
- fosinopril /
- brain natriuretic peptide

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[6]	谢亚芹,赵娟,李秀华,等.福辛普利对慢性心力衰竭大鼠心肌细胞凋亡及相关基因表达的影响[J].中国循环杂志,2016, 31(3):285-288.
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玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

doi: 10.3969/j.issn.1006-0111.2017.03.018

1. 上海市浦东新区浦南医院药剂科, 上海 200125

2. 上海市中医药大学中药学院, 上海 201210

基金项目: 浦东新区中医药事业发展专项资金"院内制剂和经验方规范化临床验证"项目（PDYNZJ2015-09）

收稿日期: 2017-01-01
修回日期: 2017-04-05

关键词:

充血性心力衰竭 /

玄参 /

福辛普利 /

脑钠肽

摘要: 目的临床观察玄参配方颗粒联合福辛普利治疗充血性心力衰竭（CHF）的疗效。方法 60例充血性心力衰竭患者，随机分为治疗组30例和对照组30例。在常规治疗基础上，对照组给予福辛普利的治疗，治疗组给予玄参配方颗粒联合福辛普利，疗程均为90 d，评价临床疗效，测定治疗前后左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数（LVEF）和血清B型脑钠肽（BNP）的浓度。结果治疗组和对照组的总有效率均为90%，但治疗组的显效例数大于对照组。与治疗前比较，治疗组和对照组的BNP、LVEDD和LVESD均显著降低，LVEF显著增加，差异均具有统计学意义（P<0.01）。治疗组改善心功能的程度优于对照组（P<0.05）。结论玄参配方颗粒联合福辛普利治疗CHF有明显疗效。

English Abstract

Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure

1. Department of Pharmacy, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China

2. Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China

Received Date: 2017-01-01
Rev Recd Date: 2017-04-05

Keywords:

Abstract: Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure. Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatment group and 30 patients in the control group. Besides the conventional therapy, the control group was treated with fosinopril and the treatment group received Scrophularia ningpoensis granules plus fosinopril for 90 days. Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and serum B-type brain natriuretic peptide (BNP) were measured before and after treatment. Results The total effective rate in the treatment group and the control group were 90%, but significantly effective number in the treatment group was higher than the control group. The levels of BNP, LVEDD and LVESD in both groups were decreased, while LVEF was increased after the treatment. The difference was statistically significant (P<0.01). The degree of improvement of heart function in the treatment group was better than that in the control group (P<0.05). Conclusion The combination therapy of Scrophularia ningpoensis granules and fosinopril is efficacious in treating CHF.

引用本文:

Citation:

QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun. Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018

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玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

doi: 10.3969/j.issn.1006-0111.2017.03.018

Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure

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玄参配方颗粒联合福辛普利治疗充血性心力衰竭的疗效观察

doi: 10.3969/j.issn.1006-0111.2017.03.018

1. 上海市浦东新区浦南医院药剂科, 上海 200125 2. 上海市中医药大学中药学院, 上海 201210

English Abstract

Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure

1. Department of Pharmacy, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China 2. Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China

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目录

1. 上海市浦东新区浦南医院药剂科, 上海 200125

2. 上海市中医药大学中药学院, 上海 201210

1. Department of Pharmacy, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China

2. Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China