Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

YU Hui; YANG Hong; WAN Fanghui; HAN Xuemin; WANG Daoling; ZHAO Xiaohong

doi:10.3969/j.issn.1006-0111.2016.05.008

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To evaluate effects of dexmedetomidine on onset, duration of supraclavicular brachial plexus block induced by levobupivacaine and postoperative analgesia with ultrasound guide. Methods Eighty patients undergoing elective surgeries of distal arm and forearm with class Ⅰ~Ⅱ ASA were enrolled, and the patients were randomly divided into two groups, one was control group (group C) patients with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 1 ml normal saline, the other was dexmedetomidine group patients (group D) with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 100 μg dexmedetomidine. The supraclavicular brachial plexus block was guided with ultrasound. Observation indicators include: sensory and motor onset blocks, duration of sensory and motor blocks, time to first rescue analgesia and hemodynamic parameters. Results The differences of sensory block onset between group C and D were not significant. Compared to group C, motor block onset of group D was significantly shorter (P<0.01), sensory block duration and motor block duration were longer (P<0.001), time to first rescue analgesia after the surgeries was longer (P<0.001). Mean arterial pressure and mean heart rate of group D were significantly lower than those of group C, respectively (P<0.02). Conclusions Dexmedetomidine can significantly prolong the duration of block and postoperative analgesia of supraclavicular brachial plexus block induced by levobupivacaine.

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

1. Department of Anesthesiology, Huaibei people's Hospital, Huaibei 235000, China

2. Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 201399, China

Received Date: 2015-09-13

Rev Recd Date: 2016-04-16

Key words:

Abstract: Objective To evaluate effects of dexmedetomidine on onset, duration of supraclavicular brachial plexus block induced by levobupivacaine and postoperative analgesia with ultrasound guide. Methods Eighty patients undergoing elective surgeries of distal arm and forearm with class Ⅰ~Ⅱ ASA were enrolled, and the patients were randomly divided into two groups, one was control group (group C) patients with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 1 ml normal saline, the other was dexmedetomidine group patients (group D) with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 100 μg dexmedetomidine. The supraclavicular brachial plexus block was guided with ultrasound. Observation indicators include: sensory and motor onset blocks, duration of sensory and motor blocks, time to first rescue analgesia and hemodynamic parameters. Results The differences of sensory block onset between group C and D were not significant. Compared to group C, motor block onset of group D was significantly shorter (P<0.01), sensory block duration and motor block duration were longer (P<0.001), time to first rescue analgesia after the surgeries was longer (P<0.001). Mean arterial pressure and mean heart rate of group D were significantly lower than those of group C, respectively (P<0.02). Conclusions Dexmedetomidine can significantly prolong the duration of block and postoperative analgesia of supraclavicular brachial plexus block induced by levobupivacaine.

HTML

Reference (10)

[1]	Kanazi GE, Aouad MT, Jabbour-Khoury SI, et al. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block[J]. Acta Anaesthesiol Scand, 2006,50:222-227.
[2]	Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics[J]. Acta Anaesthesiol Scand,2009,53:251-256.
[3]	Saumya B, Ratan K, Gauri M, et al. Dexmedetomidine an adjuvant to levobupivacaine in supraclavicular brachial plexus block: a randomized double blind prospective study[J]. Ethiop J Health Sci,2014,24(3):203-208.
[4]	Brummett C, Padda A, Amodeo F, et al. Perineural dexmedetomidine added to ropivacine causes a dose dependent increase in the duration of thermal antinociception in sciatic nerve block in rat[J]. Anesthesiology, 2009, 111:1111-1119.
[5]	Brummett C, Norat M, Palmisano J, et al. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat[J]. Anesthesiology, 2008, 109:502-511.
[6]	Alireza M, Asadollah S, Alireza S, et al. Effects of dexmedetomidine Vs ketorolac as local anesthetic adjuvants on the onset and duration of infraclavicular brachial plexus block[J]. Anesth Pain Med, 2014, 4(3): e17620.
[7]	Ammar AS, Mahmoud KM. Ultrasound-guided single injection infraclavicular brachial plexus block using bupivacaine alone or combined with dexmedetomidine for pain control in upper limb surgery: A prospective randomized controlled trial[J]. Saudi J Anaesth, 2012, 6(2):109-114.
[8]	朱新杰,马瑞,胡芳宝,等. 右美托咪啶对超声引导下罗哌卡因臂丛神经阻滞效果的影响[J].实用疼痛学杂志,2011,7(2):102-105.
[9]	周俊,王汉兵,林文静,等. 右美托咪啶对上肢手术患者罗哌卡因臂丛神经阻滞效果及上肢缺血再灌注损伤的影响[J]. 中华麻醉学杂志, 2011,31(1):84-87.
[10]	李红,程艳欣,陈永学,等. 右美托咪啶对罗哌卡因臂丛神经阻滞半数有效浓度的影响[J]. 河北医科大学学报,2012,33(8):919-922.

Message Board

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

doi: 10.3969/j.issn.1006-0111.2016.05.008

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views