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丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展

冯晶晶,  李铁军,  章越凡

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文章导航 > 药学实践与服务  > 2018 >  36(2): 108-111
冯晶晶, 李铁军, 章越凡. 丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展[J]. 药学实践与服务, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
引用本文: 冯晶晶, 李铁军, 章越凡. 丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展[J]. 药学实践与服务, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
shu
FENG Jingjing, LI Tiejun, ZHANG Yuefan. Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
Citation: FENG Jingjing, LI Tiejun, ZHANG Yuefan. Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
shu

丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展

doi: 10.3969/j.issn.1006-0111.2018.02.003
  • 1.

    安徽中医药大学药学院, 安徽 合肥 230012

  • 2.

    安徽中医药大学药学院, 安徽 合肥 230012;上海市浦东新区浦南医院药剂科, 上海 200125

  • 3.

    第二军医大学药学院药理学教研室, 上海 200433

基金项目: 浦东新区卫生系统重要薄弱学科建设资助（PWZbr2017-16）

Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia

  • 1.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China

  • 2.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;Department of Pharmacy, Punan Hospital of Pudong New Area, Shanghai 200125, China

  • 3.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 丹参酮ⅡA是从丹参中提取的一种菲醌类衍生物，是丹参发挥脑缺血损伤保护药理作用的主要活性成分之一。炎症在脑缺血发病机制中具有重要作用。近年来许多证据表明，免疫细胞、黏附分子、炎性介质等通过诱导或调控脑缺血时中枢神经系统内免疫应答参与发病过程。综述丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展，为丹参酮ⅡA的脑缺血保护作用机制研究提供新思路。
    Abstract: Tanshinone ⅡA is a kind of phenanthraquinone derivatives derived from Salvia miltiorrhiza, which is one of the main active components of Danshen to play the protective role of cerebral ischemic injury. Inflammation plays an important role in the pathogenesis of cerebral ischemia. In recent years, much evidence shows that immune cells, adhesion molecules, inflammatory mediators have been involved in the pathogenesis of immune response in the central nervous system through induction or regulation of cerebral ischemia. In this paper, the research progress of mechanism of inflammatory response of tanshinone ⅡA after cerebral ischemia was reviewed, which provided a new idea for the study of the protective mechanism of tanshinone ⅡA in cerebral ischemia.
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  • 收稿日期:  2017-08-24
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丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展

doi: 10.3969/j.issn.1006-0111.2018.02.003
  • 1. 安徽中医药大学药学院, 安徽 合肥 230012
  • 2. 安徽中医药大学药学院, 安徽 合肥 230012;上海市浦东新区浦南医院药剂科, 上海 200125
  • 3. 第二军医大学药学院药理学教研室, 上海 200433
    • 基金项目:  浦东新区卫生系统重要薄弱学科建设资助（PWZbr2017-16）
  • 收稿日期: 2017-08-24
  • 修回日期: 2017-10-11

摘要: 丹参酮ⅡA是从丹参中提取的一种菲醌类衍生物，是丹参发挥脑缺血损伤保护药理作用的主要活性成分之一。炎症在脑缺血发病机制中具有重要作用。近年来许多证据表明，免疫细胞、黏附分子、炎性介质等通过诱导或调控脑缺血时中枢神经系统内免疫应答参与发病过程。综述丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展，为丹参酮ⅡA的脑缺血保护作用机制研究提供新思路。

English Abstract

冯晶晶, 李铁军, 章越凡. 丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展[J]. 药学实践与服务, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
引用本文: 冯晶晶, 李铁军, 章越凡. 丹参酮ⅡA对脑缺血后炎性反应影响机制的研究进展[J]. 药学实践与服务, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
shu
FENG Jingjing, LI Tiejun, ZHANG Yuefan. Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
Citation: FENG Jingjing, LI Tiejun, ZHANG Yuefan. Progress of tanshinone ⅡA on the mechanism of inflammatory response after cerebral ischemia[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 108-111. doi: 10.3969/j.issn.1006-0111.2018.02.003
shu

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