多肽类化合物在颅脑创伤中的研究进展

马凯源; 章越凡; 李铁军

doi:10.3969/j.issn.1006-0111.2017.06.004

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004

1.
安徽中医药大学药学院, 安徽合肥 230012
2.
第二军医大学药学院药理学教研室, 上海 200433
3.
安徽中医药大学药学院, 安徽合肥 230012;第二军医大学药学院药理学教研室, 上海 200433

基金项目: 上海市卫生和计划生育委员会科研课题（201640404）

Research progress of peptide compounds in traumatic brain injury

1.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2.
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 颅脑创伤每年在全球造成严重的伤亡，至今研究者们依然没有找到有效的临床治疗药物。肽类物质以其安全、易耐受等优势逐渐成为研究开发的热点。对多肽类化合物在颅脑创伤中的神经保护和抗炎作用进行综述。
- 颅脑创伤 /
- 肽类药物 /
- 神经保护 /
- 抗炎
Abstract: Traumatic brain injuries(TBI) have caused severe injuries and deaths all over the world, but so far researchers have not found an effective drug in treating TBI on clinic. However, peptides have gradually been in a hot research with its advantages which include safety and tolerance etc. The neuroprotective and anti-inflammatory effects of several peptide compounds in traumatic brain injury are reviewed in this paper.
- traumatic brain injury /
- peptides /
- neuroprotection /
- anti-inflammatory

[1]	惠纪元,龚如,梁玉敏,等. 中国颅脑创伤数据库:短期预后因素分析[J]. 中华神经外科杂志,2014,30(1):56-58.
[2]	江基尧. 中国颅脑创伤研究的现状与未来[J]. 中华医学杂志,2013,93(23):1761-1762.
[3]	Stein DG,Wright DW. Progesterone in the clinical treatment of acute traumatic brain injury[J]. Expert Opin Investig Drugs,2010,19(7):847-857.
[4]	王克全,徐寒梅. 多肽类药物的研究进展[J]. 药学进展,2015,39(9):642-650.
[5]	Lee EH,Seo SR. Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases[J]. BMB Rep,2014,47(7):369-375.
[6]	Katahira M,Yone K,Arishima Y,et al.The neuroprotective effects of PACAP on spinal cord injury (SCI) in rats[J]. Regul Pept,2003,115(1):49.
[7]	Reglodi D,Kiss P,Lubics A,et al. Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo[J]. Curr Pharm Des,2011,17(10):962-972.
[8]	Farkas O,Tamás A,Zsombok A,et al. Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury[J]. Regul Pept,2004,123(1-3):69-75.
[9]	Vukojevic J,Vrdoljak B,Malekinusic D,et al. The effect of BPC 157 on ischemic/reperfusion injuriesin rat brain[J]. FASEB J,2016,30(1Suppl):705-706.
[10]	Tudor M,Jandric I,Marovic A,et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect[J]. Regul Pept,2010,160(1-3):26-32.
[11]	Tohyama Y,Sikirié P,Diksic M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain:alpha-methyl-L-tryptophan autoradiographic measurements[J]. Life Sci,2004,76(3):345-357.
[12]	Amiri-Nikpour MR,Nazarbaqhi S,Ahmadi-Salmasi B,et al. Cerebrolysin effects on neurological outcomes and cerebral blood flow in acute ischemic stroke[J]. Neuropsychiatr Dis Treat,2014,10:2299.
[13]	Sharma HS,Zimmermann-Meinzingen S,Johanson CE. Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change,brain pathology,and functional deficits following traumatic brain injury in the rat[J]. Ann N Y Acad Sci,2010,1199:125-137.
[14]	Chen CC,Wei ST,Tsaia SC,et al. Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients:double-blind,placebo-controlled,randomized study[J]. Br J Neurosurg,2013,27(6):803-807.
[15]	álvarez XA,Figueroa J,Muresanu D. Peptidergic drugs for the treatment of traumatic brain injury[J]. Futr Neurol,2013,8(2):175-192.
[16]	Faden AI,Fox GB,Fan L,et al. Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents[J]. Am J Physiol,1999,277(4 Pt 2):R1196-R1204.
[17]	Jain KK. Neuroprotection in traumatic brain injury[J]. Drug Discov Today, 2008,13(23-24):1082-1089.
[18]	Faden AI,Knoblach SM,Cernak I,et al. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo[J].J Cerebr Blood Flow Metabol,2003:342-354.
[19]	Faden AI,Movsesyan VA,Knoblach SM,et al. Neuroprotective effects of novel small peptides in vitro and after brain injury[J]. Neuropharmacology,2005,49(3):410-424.
[20]	Faden AI,Knoblach SM,Movsesyan VA,et al. Novel small peptides with neuroprotective and nootropic properties[J]. J Alzheimers Dis,2004,6(6 Suppl):S93-S97.
[21]	李淑敏. 促红细胞生成素的临床应用进展[J]. 职业与健康,2013,29(21):2862-2864.
[22]	Corwin HL,Gettinger A,Fabian TC,et al. Efficacy and safety of epoetin Alfa in criticallyⅢ patients[J]. New Engl J Med,2007,357(10):965-976.
[23]	Collino M,Thiemermann C,Cerami A,et al. Flipping the molecular switch for innate protection and repair of tissues:Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin[J]. Pharmacol Ther,2015,151:32-40.
[24]	Robertson CS,Cherian L,Shah M,et al. Neuroprotection with an erythropoietin mimetic peptide (pHBSP) in a model of mild traumatic brain injury complicated by hemorrhagic shock[J]. J Neurotr,2012,29(6):1156-1166.
[25]	Verghese PB,Castellano JM,Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders[J]. Lancet Neurol,2011,10(3):241-252.
[26]	Jiang Y,Brody DL. Administration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice[J]. J Neurotr,2012,29(13):2332-2341.
[27]	Laskowitz DT,Mckenna SE,Song P,et al. COG1410,a novel apolipoprotein E-basedpeptide,improves functional recovery in a murine model of traumatic brain injury[J]. J Neurotr,2007,24(7):1093-1107.
[28]	贺杰,庞金伟,吴越,等. 载脂蛋白E短肽COG1410对蛛网膜下腔出血后早期脑水肿的影响[J]. 第三军医大学学报,2016,38(4):350-355.
[29]	Wu Y,Pang J,Peng J,et al. An apoE-derived mimic peptide,COG1410,alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage[J].Neurosci Lett,2016,627:92-99.

[1]	郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛. 醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2025, 43(3): 136-142, 150. doi: 10.12206/j.issn.2097-2024.202310043
[2]	张霖峰, 孙宇恒, 王冬尧, 李丹, 曹岩, 吕狄亚. 茵陈蒿汤体内成分分析及其抗肝癌作用机制的网络药理学研究 . 药学实践与服务, 2025, 43(): 1-9. doi: 10.12206/j.issn.2097-2024.202501017
[3]	邱彦, 吴浩, 董雅芬, 陈业, 王建, 金辉. 新型二氢卟吩化合物的光动力性能及其抗肺癌作用研究 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202304011
[4]	王晓丹, 刘文杰, 宋畅, 董文星, 赵倩, 马骁龙. 利多卡因凝胶贴膏联合普瑞巴林治疗带状疱疹后神经痛患者疗效及对血清疼痛介质的影响 . 药学实践与服务, 2025, 43(11): 572-576. doi: 10.12206/j.issn.2097-2024.202505036
[5]	张俊丽, 李媛媛, 尹静, 杨鸿源, 白耀武. 咪达唑仑调节PINK1/PARKIN信号通路对缺血性脑卒中大鼠神经元损伤的影响 . 药学实践与服务, 2025, 43(6): 288-292, 312. doi: 10.12206/j.issn.2097-2024.202405024
[6]	宋泽成, 马闪闪, 胡巧灵, 仲华, 王彦. 小檗碱与氟康唑合用抗氟康唑耐受白念珠菌的研究 . 药学实践与服务, 2025, 43(2): 87-91. doi: 10.12206/j.issn.2097-2024.202409047
[7]	冯一帆, 严啸东, 张文彬, 李炳锋, 郭美丽. 菸花苷长期给药对脑缺血再灌注损伤大鼠神经功能的影响 . 药学实践与服务, 2025, 43(5): 228-234. doi: 10.12206/j.issn.2097-2024.202407038
[8]	高洁, 林心兰, 王兆骞, 张青亭, 李静静, 张凤. 生物制剂治疗强直性脊柱炎的研究进展 . 药学实践与服务, 2025, 43(7): 320-324. doi: 10.12206/j.issn.2097-2024.202502005
[9]	卢熠菲, 宋佳, 沈红霞, 赵庆杰. 新型苦参碱衍生物的设计合成与体外抗炎活性研究 . 药学实践与服务, 2025, 43(): 1-8. doi: 10.12206/j.issn.2097-2024.202503005
[10]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架治疗创伤性脑损伤的研究 . 药学实践与服务, 2025, 43(2): 67-74. doi: 10.12206/j.issn.2097-2024.202406034
[11]	关梦瑶, 夏天爽, 何旭辉, 史策, 蒋益萍, 辛海量. 黑蒜多糖抗便秘作用研究 . 药学实践与服务, 2025, 43(4): 190-194. doi: 10.12206/j.issn.2097-2024.202403059
[12]	何琳, 成彦琼, 叶侃倜, 赵娟娟, 陆蕙兰, 杨骏, 陈方剑. 血通胶囊降血脂以及肝脏保护作用研究 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202502015
[13]	吴若南, 叶爽, 李墨晨轩, 缪震元, 罗川. 冬凌草甲素磺酰脲衍生物的设计与抗炎活性研究 . 药学实践与服务, 2025, 43(7): 335-338, 352. doi: 10.12206/j.issn.2097-2024.202401048
[14]	陶宫佳, 陈林林, 宋泽成, 刘梦肖, 王彦. 苦参碱及衍生物的抗炎作用及其机制研究进展 . 药学实践与服务, 2025, 43(4): 163-168, 194. doi: 10.12206/j.issn.2097-2024.202406035
[15]	张元林, 宋凯, 孙蕊, 舒飞, 舒丽芯, 杨樟卫. 基于真实世界数据的药物利用研究综述 . 药学实践与服务, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
[16]	白学鑫, 陈玉平, 盛春泉, 武善超. 具核梭杆菌小分子抑制剂的筛选及其抗结直肠癌活性研究 . 药学实践与服务, 2024, 42(12): 503-507. doi: 10.12206/j.issn.2097-2024.202405009
[17]	张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲. 新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
[18]	张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳. 基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
[19]	杨念, 张博乐, 张俊霞, 张振强. 一种中药组合物对ANIT诱导的小鼠胆汁淤积肝损伤的保护作用研究 . 药学实践与服务, 2024, 42(12): 508-511, 519. doi: 10.12206/j.issn.2097-2024.202305008
[20]	何亚伦, 祁智, 常杰. 消胀通便膏在晚期肝癌患者阿片类药物相关性便秘中的应用研究 . 药学实践与服务, 2024, 42(12): 520-523. doi: 10.12206/j.issn.2097-2024.202309009

点击查看大图

计量

文章访问数: 3700
HTML全文浏览量: 501
PDF下载量: 576
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004

Research progress of peptide compounds in traumatic brain injury

计量

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004

1. 安徽中医药大学药学院, 安徽合肥 230012

2. 第二军医大学药学院药理学教研室, 上海 200433

3. 安徽中医药大学药学院, 安徽合肥 230012;第二军医大学药学院药理学教研室, 上海 200433

English Abstract

Research progress of peptide compounds in traumatic brain injury

全文HTML

目录

留言板

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004

Research progress of peptide compounds in traumatic brain injury

计量

出版历程

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004

1. 安徽中医药大学药学院, 安徽 合肥 230012 2. 第二军医大学药学院药理学教研室, 上海 200433 3. 安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院药理学教研室, 上海 200433

English Abstract

Research progress of peptide compounds in traumatic brain injury

全文HTML

目录

1. 安徽中医药大学药学院, 安徽合肥 230012

2. 第二军医大学药学院药理学教研室, 上海 200433

3. 安徽中医药大学药学院, 安徽合肥 230012;第二军医大学药学院药理学教研室, 上海 200433