[1] NAQVI K F, MAZZONE S B, SHILOH M U. Infectious and inflammatory pathways to cough[J]. Annu Rev Physiol, 2023, 85: 71-91. doi:  10.1146/annurev-physiol-031422-092315
[2] 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2021)[J]. 中华结核和呼吸杂志, 2022, 45(1): 13-46.
[3] 国家药典委员会. 中华人民共和国药典: 一部[S]. 北京: 中国医药科技出版社, 2020: 125.
[4] WU G Y, WEI X Q, LI D M, et al. Selection and evaluation of quality markers for the regulation of PXR-CYP3A4/FXR-LXRα by Exocarpium Citri Grandis for the treatment of hyperlipidaemia with dispelling blood stasis and removing phlegm[J]. Biomed Pharmacother, 2024, 170: 116089. doi:  10.1016/j.biopha.2023.116089
[5] CHEN T T, WU X Q, WANG D N, et al. Exocarpium citri grandis ameliorates metabolic disorders by inhibiting inflammatory responses and NLRP3 inflammasome activation[J]. Food Sci Nutr, 2025, 13(11): e71074. doi:  10.1002/fsn3.71074
[6] ZHU X T, LI J, XIAO G S, et al. Key metabolic pathways of the aging process of Citri Grandis Exocarpium and its identified potential metabolites associated with antioxidant activity[J]. npj Sci Food, 2025, 9: 57. doi:  10.1038/s41538-025-00411-0
[7] CHEN J, QIN X, CHEN M Y, et al. Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome[J]. Pharmacol Res, 2024, 202: 107124. doi:  10.1016/j.phrs.2024.107124
[8] ZHAO X Y, XIU J, YANG H Z, et al. Network pharmacology and bioinformatics study of six medicinal food homologous plants against colorectal cancer[J]. Int J Mol Sci, 2025, 26(3): 930. doi:  10.3390/ijms26030930
[9] TANG D D, CHEN M J, HUANG X H, et al. SRplot: a free online platform for data visualization and graphing[J]. PLoS One, 2023, 18(11): e0294236. doi:  10.1371/journal.pone.0294236
[10] LIU Y, YANG X C, GAN J H, et al. CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting[J]. Nucleic Acids Res, 2022, 50(W1): W159-W164. doi:  10.1093/nar/gkac394
[11] 孙增涛, 师艺航, 李小娟. 咳嗽中医诊疗专家共识意见(2021)[J]. 中医杂志, 2021, 62(16): 1465-1472.
[12] 张瑜, 吴国珍. 橘红痰咳液治疗外感风寒(或夹湿)型咳嗽疗效观察[J]. 世界科学技术-中医药现代化, 2017, 19(6): 1026-1030.
[13] HUA F Z, YING J, ZHANG J, et al. Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-κB-mediated inflammation[J]. Int J Mol Med, 2016, 38(4): 1271-1280. doi:  10.3892/ijmm.2016.2715
[14] WANG Q Y, OU Y J, HU G M, et al. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice[J]. Br J Pharmacol, 2020, 177(8): 1806-1821. doi:  10.1111/bph.14938
[15] KANG G D, KIM D H. Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance[J]. J Ethnopharmacol, 2016, 189: 175-185. doi:  10.1016/j.jep.2016.05.044
[16] CHEN S, WANG X J, CHENG Y, et al. A review of classification, biosynthesis, biological activities and potential applications of flavonoids[J]. Molecules, 2023, 28(13): 4982. doi:  10.3390/molecules28134982
[17] ATILA USLU G, USLU H, ÇOBAN T A, et al. Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities[J]. Naunyn Schmiedeberg’s Arch Pharmacol, 2025, 398(7): 8543-8554. doi:  10.1007/s00210-024-03773-6
[18] HE D X, WANG S Q, FANG G F, et al. LXRs/ABCA1 activation contribute to the anti-inflammatory role of phytosterols on LPS-induced acute lung injury[J]. J Funct Foods, 2022, 89: 104966. doi:  10.1016/j.jff.2022.104966
[19] KAN S A. β-sitosterol suppresses fibroblast growth factor and epidermal growth factor receptors to induce apoptosis and inhibit migration in lung cancer: an in vitro study[J]. Am J Cancer Res, 2025, 15(3): 1109-1121. doi:  10.62347/nzcg1179
[20] LIU J H, YAO J D, ZHANG J. Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB[J]. J Microbiol Biotechnol, 2018. DOI: 10.4014/jmb.1810.10061.
[21] XU J F, YANG L, LIN T T. β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma[J]. Pulm Pharmacol Ther, 2023, 78: 102183. doi:  10.1016/j.pupt.2022.102183
[22] WANG K, LI J Z, ZHANG H, et al. Tobacco smoking rewires cell metabolism by inducing GAPDH succinylation to promote lung cancer progression[J]. Cancer Res, 2025, 85(15): 2838-2857. doi:  10.1158/0008-5472.CAN-24-3525
[23] NIE Y J, HU Y D, YU K K, et al. Akt1 regulates pulmonary fibrosis via modulating IL-13 expression in macrophages[J]. Innate Immun, 2019, 25(7): 451-461. doi:  10.1177/1753425919861774
[24] SCHRAMM F, SCHAEFER L, WYGRECKA M. EGFR signaling in lung fibrosis[J]. Cells, 2022, 11(6): 986. doi:  10.3390/cells11060986
[25] HE Y C, LI F, ZHANG C, et al. Therapeutic effects of the bcl-2 inhibitor on bleomycin-induced pulmonary fibrosis in mice[J]. Front Mol Biosci, 2021, 8: 645846. doi:  10.3389/fmolb.2021.645846
[26] YANG Z, KAO X Y, ZHANG L, et al. Exploring the anti-PANoptosis mechanism of dachaihu decoction against sepsis-induced acute lung injury: network pharmacology, bioinformatics, and experimental validation[J]. Drug Des Dev Ther, 2025, 19: 349-368. doi:  10.2147/DDDT.S495225
[27] LIU S Q, HU C P, LI M, et al. Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression[J]. Cell Death Dis, 2022, 13: 70. doi:  10.1038/s41419-022-04514-4
[28] SATHISH V, FREEMAN M R, LONG E, et al. Cigarette smoke and estrogen signaling in human airway smooth muscle[J]. Cell Physiol Biochem, 2015, 36(3): 1101-1115. doi:  10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3605
[29] MCCLENDON J, JANSING N L, REDENTE E F, et al. Hypoxia-inducible factor 1α signaling promotes repair of the alveolar epithelium after acute lung injury[J]. Am J Pathol, 2017, 187(8): 1772-1786. doi:  10.1016/j.ajpath.2017.04.012
[30] LU Y, WU Y, HUANG M F, et al. Fuzhengjiedu formula exerts protective effect against LPS-induced acute lung injury via gut-lung axis[J]. Phytomedicine, 2024, 123: 155190. doi:  10.1016/j.phymed.2023.155190