[1] Gammon K. Neurodegenerative disease:brain windfall[J]. Nature, 2014, 515(7526):299-300.
[2] Chen RL, Balami JS, Esiri MM, et al. Ischemic stroke in the elderly:an overview of evidence[J]. Nat Rev Neurol, 2010, 6(5):256-65.
[3] 佟玲, 苏志强. 炎性小体在脑缺血中的作用[J]. 国际脑血管病杂志, 2017, 25(2):170-173.
[4] Zhang F, Yan C, Wei C, et al. Vinpocetine inhibits NF-κB-dependent inflammation in acute ischemic stroke patients[J]. Transl Stroke Res, 2017.
[5] Shang YH, Tian JF, Hou M, et al. Progress on the protective effect of compounds from natural medicines on cerebral ischemia[J]. Chin J Nat Med, 2013, 11(6):588-595.
[6] 李德川, 鲍秀琦, 孙华,等. 丹参酮ⅡA对缺血性脑中风的神经保护作用研究进展[J]. 药学学报, 2015, 50(6):635-639.
[7] Zhao SC, Ma LS, Chu ZH, et al. Regulation of microglial activation in stroke[J]. Acta Pharmacol Sin, 2017, 38(4):445-458.
[8] 熊怀林, 范光碧,胡兴宇. 小胶质细胞在脑缺血中的作用[J]. 四川解剖学杂志, 2005,13(2):35-37.
[9] Cai L, Yi XB, Yuan LB, et al. The protective effect of tanshinone ⅡA on oxygen-glucose deprivation and reperfusion injury of microglia through the NLRP3 inflammatory signaling pathway[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2016, 47(5):660-664.
[10] Wang Y, Yang L, Yang D. Tanshinone ⅡA rescued the impairments of primary hippocampal neurons induced by BV2 microglial over-activation[J]. Neurochem Res, 2015, 40(7):1497-1508.
[11] 宋兆晶, 吉训明, 牛小媛,等. 脑缺血后炎性反应机制的研究进展[J].中国脑血管病杂志, 2010, 7(3):154-157.
[12] Zhou L, Bondy SC, Jian L, et al. Tanshinone ⅡA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8[J]. Neuroscience, 2015, 288:105-111.
[13] Yang X, Yan J, Feng J. Treatment with tanshinone ⅡA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis[J]. Eur J Pharmacol, 2016, 771:18-28.
[14] Caso JR, Moro MA, Lorenzo P, et al. Involvement of IL-1beta in acute stress-induced worsening of cerebral ischaemia in rats[J]. Eur Neuropsychopharmacol, 2007, 17(9):600-607.
[15] Jung JE, Kim GS, Chan PH. Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke[J]. Stroke, 2011, 42(12):3574-3579.
[16] Zhou L, Zhang J, Wang C, et al. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model[J]. Int J Immunopathol Pharmacol, 2017, 30(2):123-129.
[17] Chen Y, Wu X, Yu S, et al. Neuroprotection of tanshinone ⅡA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats[J]. PLoS ONE, 2012, 7(6):e40165.
[18] Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia[J]. Surg Neurol, 2006, 66(3):232-245.
[19] Tang C, Xue H, Bai C, et al. The effects of Tanshinone ⅡA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats[J]. Phytomedicine, 2010, 17(14):1145-1149.
[20] Liu P, Zhao H, Wang R, et al. MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress[J]. Stroke, 2015, 46(2):513-519.
[21] Davis SM, Pennypacker KR. Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke[J]. Neurochem Int, 2017, 107:23-32.
[22] Greco R, Demartini C, Zanaboni AM, et al. Endothelial nitric oxide synthase inhibition triggers inflammatory responses in the brain of male rats exposed to ischemia-reperfusion injury[J]. J Neurosci Res, 2017.
[23] del Zoppo G, Ginis I, Hallenbeck JM, et al. Inflammation and stroke:putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia[J]. Brain Pathol, 2000, 10(1):95-112.
[24] Tang C, Xue HL, Bai CL, et al. Regulation of adhesion molecules expression in TNF-α-stimulated brain microvascular endothelial cells by tanshinone ⅡA:involvement of NF-κB and ROS generation[J]. Phytother Res, 2011, 25(3):376-380.
[25] Tuttolomondo A, Di Sciacca R, Di Raimondo D, et al. Inflammation as a therapeutic target in acute ischemic stroke treatment[J]. Curr Top Med Chem, 2009, 9(14):1240-1260.
[26] Turner RJ, Sharp FR. Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke[J]. Front Cell Neurosci, 2016, 10:56.
[27] Zhu Y, Tang Q, Wang G, et al. Tanshinone ⅡA protects hippocampal neuronal cells from reactive oxygen species through changes in autophagy and activation of phosphatidylinositol 3-kinase, protein kinas B, and mechanistic target of rapamycin pathways[J]. Curr Neurovasc Res, 2017, 14(2):132-140.
[28] Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke[J]. J Neuroimmunol, 2007, 184(1-2):53-68.
[29] Dong K, Xu W, Yang J, et al. Neuroprotective effects of Tanshinone ⅡA on permanent focal cerebral ischemia in mice[J]. Phytother Res, 2009, 23(5):608-613.
[30] Wang JG, Bondy SC, Zhou L, et al. Protective effect of tanshinone ⅡA against infarct size and increased HMGB1, NF-κB, GFAP and apoptosis consequent to transient middle cerebral artery occlusion[J]. Neurochem Res, 2014, 39(2):295-304.
[31] Leyton-Jaimes MF, Kahn J, Israelson A. Macrophage migration inhibitory factor:A multifaceted cytokine implicated in multiple neurological diseases[J]. Exp Neurol, 2017.