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Volume 30 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(4): 302-304

LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
Citation: LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
shu

Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection

  • Beijing Double-crane Pharmaceutical Co., Ltd, Beijing 100102, China

  • Received Date: 2011-12-27
  • Rev Recd Date: 2012-02-27
  • Objective To investigate the effects of Fe“on the stability of ornidazole and sodium chloride injection,and ensure the safety in elinical utility. Methods Two kinds of ornidazole and sodium chloride injection which contain no Fe3+ and trace Fe3+ were prepared respectively, The content of ornidazole was determined by HPLC at different temperatures and times,which was used to study chemical dynamics of ornidazole, According to Arrhenitls equation,stability of two kinds of ornidazole and sodium ehloride injection at room temperature were forecasted. Results The degradation of ornidazole followed the first-order reaction kinetics model. At 25℃,t0.9 of ornidazole and sodium chloride injection which not containing Fe3+ and containing trace Fe3+ were 1.71 years and 1.11 years separately. Conclusions Trace Fe3+ could accderate the degradation of ornidazole.which shortened storage period of ornidazole and sodium chloride injection.
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Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection

  • Beijing Double-crane Pharmaceutical Co., Ltd, Beijing 100102, China
  • Received Date: 2011-12-27
  • Rev Recd Date: 2012-02-27

Abstract: Objective To investigate the effects of Fe“on the stability of ornidazole and sodium chloride injection,and ensure the safety in elinical utility. Methods Two kinds of ornidazole and sodium chloride injection which contain no Fe3+ and trace Fe3+ were prepared respectively, The content of ornidazole was determined by HPLC at different temperatures and times,which was used to study chemical dynamics of ornidazole, According to Arrhenitls equation,stability of two kinds of ornidazole and sodium ehloride injection at room temperature were forecasted. Results The degradation of ornidazole followed the first-order reaction kinetics model. At 25℃,t0.9 of ornidazole and sodium chloride injection which not containing Fe3+ and containing trace Fe3+ were 1.71 years and 1.11 years separately. Conclusions Trace Fe3+ could accderate the degradation of ornidazole.which shortened storage period of ornidazole and sodium chloride injection.

LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
Citation: LIU Qian-ying, YIN An-fan, NIU Zhi-ying. Study on effects of Fe3+ on the stability of ornidazole and sodium chloride injection[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 302-304.
shu

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