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Volume 30 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(4): 289-290,309

LI Xiang, LIU Gui-yang, AM Jian-li, WANG Xiao-qing, GAO Lei, ZHANG Qin-zhe. Research on the transfer rate of baicalin in preparation of Bianyan oral solution[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 289-290,309.
Citation: LI Xiang, LIU Gui-yang, AM Jian-li, WANG Xiao-qing, GAO Lei, ZHANG Qin-zhe. Research on the transfer rate of baicalin in preparation of Bianyan oral solution[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 289-290,309.
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Research on the transfer rate of baicalin in preparation of Bianyan oral solution

  • Department of Pharmacy, First Affiliated Hospital, General Hospital of PLA, Beijing 100037, China

  • Received Date: 2012-01-03
  • Rev Recd Date: 2012-04-05
  • Objective To establish the HPLC method for determination of baicalin in Bianyan oral solution,and evaluate the transfer rate in process of production.Methods The Agilent Zorbax Eclipse XDB-C18 (4.6 mm×150 mm,5μm) was used,the mobile phase consisted of methanol-0,5% acetic acid (45:55),the flow rate was 1.0 ml/min,the detection wavelength was at 277nm,the column temperature was at 30 ℃,the inject volume was 10μl.Results A good linear correlation of baicalin was observed within the range of 1.064～106.4 μg/ml (r=0.999 9).The average recovery was 101.26% with RSD 1.92% (n=6).The transfer rates from Radix Scutellariae to intermediate sample and Io Bianyan oral solution were 17.2%～19.0% and 78.7%-79.4%.Conclusions The method was rapid.simple and accurate,which could be used for the quality control and processing technique evaluation of Bianyan oral solution.
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Research on the transfer rate of baicalin in preparation of Bianyan oral solution

  • Department of Pharmacy, First Affiliated Hospital, General Hospital of PLA, Beijing 100037, China
  • Received Date: 2012-01-03
  • Rev Recd Date: 2012-04-05

Abstract: Objective To establish the HPLC method for determination of baicalin in Bianyan oral solution,and evaluate the transfer rate in process of production.Methods The Agilent Zorbax Eclipse XDB-C18 (4.6 mm×150 mm,5μm) was used,the mobile phase consisted of methanol-0,5% acetic acid (45:55),the flow rate was 1.0 ml/min,the detection wavelength was at 277nm,the column temperature was at 30 ℃,the inject volume was 10μl.Results A good linear correlation of baicalin was observed within the range of 1.064～106.4 μg/ml (r=0.999 9).The average recovery was 101.26% with RSD 1.92% (n=6).The transfer rates from Radix Scutellariae to intermediate sample and Io Bianyan oral solution were 17.2%～19.0% and 78.7%-79.4%.Conclusions The method was rapid.simple and accurate,which could be used for the quality control and processing technique evaluation of Bianyan oral solution.

LI Xiang, LIU Gui-yang, AM Jian-li, WANG Xiao-qing, GAO Lei, ZHANG Qin-zhe. Research on the transfer rate of baicalin in preparation of Bianyan oral solution[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 289-290,309.
Citation: LI Xiang, LIU Gui-yang, AM Jian-li, WANG Xiao-qing, GAO Lei, ZHANG Qin-zhe. Research on the transfer rate of baicalin in preparation of Bianyan oral solution[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(4): 289-290,309.
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