Synthesis and antifungal activity of the novel triazole compounds

WANG Shu-dong; CHEN Xing-dong; ZHAO Qing-jie; ZOU Yan; HU Hong-gang; YU Shi-chong; WANG Ting; CHAI Xiao-yun; REN Hai-xiang

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Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and ¹H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhibited activity against fungi tested. Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.

Synthesis and antifungal activity of the novel triazole compounds

1. The Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

2. School of pharmacy, Second Military Medical University, Shanghai, 200433, China

Received Date: 2010-07-07

Rev Recd Date: 2011-03-04

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Abstract: Objective To design the synthesis and evaluate the antifungal active of the novel triazole compounds based on the structure of fluconazole. Methods The big N,N-disubstituted group was introduced and a series of compounds were synthesized, all of them were confirmed by MS and ¹H NMR, et al. The antifungal activity were also evaluated against the eight common pathogenic fungi. Results Eighteen compounds were synthesized,which exhibited activity against fungi tested. Conclusion The big N,N-disubstituted group introduced to the side chain could affected the antifungal activity.

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Reference (9)

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Synthesis and antifungal activity of the novel triazole compounds

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