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Volume 29 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(5): 347-349

LU Song-wei, SONG Hong-jie, CHEN Fang-jian. Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 347-349.
Citation: LU Song-wei, SONG Hong-jie, CHEN Fang-jian. Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 347-349.
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Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC

  • Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2011-01-05
  • Rev Recd Date: 2011-04-08
  • Objective To establish a method for simultaneous determination of phenol and camphor in compound camphor liniment by HPLC. Methods The separation was performed on a Kromasil C18 analytical column(150 mm×4.6 mm, 5 μm)with the mobile phase consisting of methanol-water(55:45).The detection wavelength was 287 nm.The flow rate was 0.8 ml/min. Results The standard curves were linear in the range of 103.4~827.2 μg/ml for phenol (r=0.999 1, n=5) and 205.1~1 640.8μg/ml(r=0.999 5, n=5)for camphor. The average recoveries of phenol and camphor were 99.61%(RSD=1.19%, n=9) and 99.83%(RSD=1.18%, n=9). Conclusion The method was simple and accurate with a good reproducibility, and could be used as a quality control method for compound camphor liniment.
  • [1] 宗永辉.高效液相色谱法测定复方氧化锌涂剂中樟脑和苯酚含量[J].中国药业,2009,18(1):16.
    [2] 余小平,舒金富,黄 华.高效液相色谱法同时测定樟脑苯酚溶液中两组分的含量[J].药物分析杂志,2006,26(8):1161.
    [3] 杨 娟,黄敬群,李 红,等.高效液相色谱法测定复方樟脑搽剂中苯酚的含量[J].中国医院药学杂志,2008,28(18):1616.
    [4] 宋洪杰,陆松伟,朱全刚,等.反相离子对色谱法测定三利巴布膏剂中盐酸利多卡因的含量[J].中国现代应用药学杂志,2008,25(2):137.
    [5] 李丽萍,毕雪艳,景金柱. HPLC法测定盐酸利多卡因胶浆(I)的含量[J].齐鲁药事,2006,25(2):92.
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Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC

  • Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2011-01-05
  • Rev Recd Date: 2011-04-08

Abstract: Objective To establish a method for simultaneous determination of phenol and camphor in compound camphor liniment by HPLC. Methods The separation was performed on a Kromasil C18 analytical column(150 mm×4.6 mm, 5 μm)with the mobile phase consisting of methanol-water(55:45).The detection wavelength was 287 nm.The flow rate was 0.8 ml/min. Results The standard curves were linear in the range of 103.4~827.2 μg/ml for phenol (r=0.999 1, n=5) and 205.1~1 640.8μg/ml(r=0.999 5, n=5)for camphor. The average recoveries of phenol and camphor were 99.61%(RSD=1.19%, n=9) and 99.83%(RSD=1.18%, n=9). Conclusion The method was simple and accurate with a good reproducibility, and could be used as a quality control method for compound camphor liniment.

LU Song-wei, SONG Hong-jie, CHEN Fang-jian. Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 347-349.
Citation: LU Song-wei, SONG Hong-jie, CHEN Fang-jian. Simultaneous determination of phenol and camphor in compound camphor liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 347-349.
shu

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