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Volume 29 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(4): 260-262,268

FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words][J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 260-262,268.
Citation: FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words][J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 260-262,268.
shu

Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words]

  • 1.

    School of pharmacy,Second Military Medical University,Shanghai 200433,China

  • 2.

    Jinbaili Food Co.; Ltd. Jinjiang 362216, China

  • Received Date: 2011-01-27
  • Rev Recd Date: 2011-02-21
  • Objective To develop a new type of chewing gum contained caffeine, and a method for determination of caffeine in the chewing gum. Methods the caffeine powder and sugar powder were mixed evenly. the mixtures were reconciled with the chewing gum which were then cutted, extruded ,cooled and packaged. The caffeine in the gum was extracted by boiling water bath for 1h and caffeine content was determind by HPLC. Results This type of gum tastd good and the caffeine contained in the gum was uniform; The calibration curve showed good linearity in the range, and the mean of the extraction recovery rate was 98.41 ± 2.02%. Methodology of this study met the requirements of determination. Conclusion The technology of caffeine gum was simple and available; the developed HPLC method was easy, rapid , accurate and the quality was under control.
  • [1] 中国药典2010版.二部[S].2010:461.
    [2] 刘职瑞,叶显撑, 王 芳,等.咖啡因口崩片的研究[J]. 药学实践杂志, 2009,27 (3) :179.
    [3] Gary H K, Chetan S K, Ronald O,et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers[J]. Int J Phar,2002, 234(1-2): 159.
    [4] 李 楠,杨 明.清咽口香糖的研制[J].食品工业科技,2006,27(01):107.
    [5] 施燕支,郭雪清, 余启荣,等.HPLC示差折光分析法测定口香糖中的木糖醇等多种糖醇的含量[J]. 首都师范大学学报(自然科学版), 2005,26(1):62.
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Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words]

  • 1. School of pharmacy,Second Military Medical University,Shanghai 200433,China
  • 2. Jinbaili Food Co.; Ltd. Jinjiang 362216, China
  • Received Date: 2011-01-27
  • Rev Recd Date: 2011-02-21

Abstract: Objective To develop a new type of chewing gum contained caffeine, and a method for determination of caffeine in the chewing gum. Methods the caffeine powder and sugar powder were mixed evenly. the mixtures were reconciled with the chewing gum which were then cutted, extruded ,cooled and packaged. The caffeine in the gum was extracted by boiling water bath for 1h and caffeine content was determind by HPLC. Results This type of gum tastd good and the caffeine contained in the gum was uniform; The calibration curve showed good linearity in the range, and the mean of the extraction recovery rate was 98.41 ± 2.02%. Methodology of this study met the requirements of determination. Conclusion The technology of caffeine gum was simple and available; the developed HPLC method was easy, rapid , accurate and the quality was under control.

FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words][J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 260-262,268.
Citation: FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words][J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 260-262,268.
shu

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