Determination of residual by headspace gas chromatography organic solvents in piroxicam

LI Yu; ZHAO Jing-xia; YANG Gen-jin; DONG Xin; LI Ling; SU Li; ZHANG Wei

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Volume 29 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2011 > 29(1): 31-32

LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.

Citation:

LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.

Determination of residual by headspace gas chromatography organic solvents in piroxicam

Center of Pharmaceutical Analysis, College of Pharmacy, Second Military Medical University, Shanghai 200433,China

Received Date: 2009-09-18
Rev Recd Date: 2009-11-26

Abstract

Objective To establish a headspace capillary gas chromatgraphy for determination the residual organic solvents in piroxicam. Methods The residual solvents in piroxicam which are methanol , ethanol, toluene and dimethybenzene were determined by headspace GC on HP-INNOWax column(30 m×0.32 mm×0.25 μm),with FID detector,high purity nitrogen as the carry gas. Results Four residual organic solvents consisting of methanol, ethanol, toluene and dimethybenzene in piroxicam were completely separated and the samples coincided with the requirements. Conclusion The method is sensitive and accurate. It is suitable to the determination of residual organic solvents in piroxicam.
- headspace gas chromatgraphy,
- piroxicam,
- residual organic solvents

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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