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Volume 28 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(6): 440-444,444

SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
Citation: SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
shu

Effect of Sodium danshensu on oxygen consumption in anesthetized dogs

  • 1.

    Shanghai Children's Hospital,Shanghai 200040,China

  • 2.

    Naval Medical Research Institute of PLA,Shanghai 200433,China

  • 3.

    School of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2010-08-30
  • Rev Recd Date: 2010-10-19
  • Objective To investigate the effects of Sodium danshensu on myocardial oxygen consumption in dogs. Methods The parameters including coronary blood flow,myocardial oxygen consumption and myocardial oxygen uptake rate in normal anaesthetic dogs were used to study the effects of Sodium danshensu on ischemic myocardium. Results Cardiac output and coronary blood flow were increased significantly and myocardial oxygen uptake rate and myocardial oxygen consumption were remarkable decreased in the periods of 5 min to 120 min when Sodium danshensu given to dogs,which had difference with that of normal saline group(P<0.01). Conclusion Sodium danshensu had protective effects on the ischemic myocardium.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of Sodium danshensu on oxygen consumption in anesthetized dogs

  • 1. Shanghai Children's Hospital,Shanghai 200040,China
  • 2. Naval Medical Research Institute of PLA,Shanghai 200433,China
  • 3. School of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2010-08-30
  • Rev Recd Date: 2010-10-19

Abstract: Objective To investigate the effects of Sodium danshensu on myocardial oxygen consumption in dogs. Methods The parameters including coronary blood flow,myocardial oxygen consumption and myocardial oxygen uptake rate in normal anaesthetic dogs were used to study the effects of Sodium danshensu on ischemic myocardium. Results Cardiac output and coronary blood flow were increased significantly and myocardial oxygen uptake rate and myocardial oxygen consumption were remarkable decreased in the periods of 5 min to 120 min when Sodium danshensu given to dogs,which had difference with that of normal saline group(P<0.01). Conclusion Sodium danshensu had protective effects on the ischemic myocardium.

SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
Citation: SHEN Yang, LUAN Jie, ZHANG Su, WANG Shen-dong, ZHANG Chuan, WANG Jia-chun. Effect of Sodium danshensu on oxygen consumption in anesthetized dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(6): 440-444,444.
shu

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