Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(4): 274-278

MENG Li-yuan, LI Xiu-bao, ZHANG Wen, LI Ling, SUN Peng, TANG Hua, LIU Bao-shu, YI Yang-hua. Bioactive constituents from Sinularia sp[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 274-278.
Citation: MENG Li-yuan, LI Xiu-bao, ZHANG Wen, LI Ling, SUN Peng, TANG Hua, LIU Bao-shu, YI Yang-hua. Bioactive constituents from Sinularia sp[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 274-278.
shu

Bioactive constituents from Sinularia sp

  • 1.

    Second Military Medical University,Research Center for Marine Drugs,School of Pharmacy,Shanghai 200433,China

  • 2.

    South China Sea Institute of Oceanology Chinese Academy of Sciences,Guangzhou 510301,china

  • Received Date: 2010-06-21
  • Rev Recd Date: 2010-07-16
  • Objective To study the bioactive constituents of soft coral Sinularia sp. Methods The compounds were isolated and purified by silica gel,Sephadex LH-20 column chromatography and HPLC.Their chemical structures were identified by spectroscopic analysis. Results Seven sterol compounds were identified that are: ergos-7,24(28)-dien-3β,5α,6β-triol(1),(24R)-ergost-7,22-dien-3β,5α,6β-triol(2),ergost-24(28)-en-3β,5α,6β-triol(3),(24 S)-ergost-7(8)-en-3β,5α,6β-triol(4),23-demethylgorgost-7-en-3β,5α,6β-triol(5),ergosterol peroxide(6),cholesterol(7). Conclusion s All these compounds have the ergost-3β,5α,6β-tiol substructure segment except the common ergosterol peroxide and cholesterol.Preliminary bioactive experiment indicated that these compounds have the effect of antimicrobial activity.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2039) PDF downloads(311) Cited by()

Related
Proportional views

Bioactive constituents from Sinularia sp

  • 1. Second Military Medical University,Research Center for Marine Drugs,School of Pharmacy,Shanghai 200433,China
  • 2. South China Sea Institute of Oceanology Chinese Academy of Sciences,Guangzhou 510301,china
  • Received Date: 2010-06-21
  • Rev Recd Date: 2010-07-16

Abstract: Objective To study the bioactive constituents of soft coral Sinularia sp. Methods The compounds were isolated and purified by silica gel,Sephadex LH-20 column chromatography and HPLC.Their chemical structures were identified by spectroscopic analysis. Results Seven sterol compounds were identified that are: ergos-7,24(28)-dien-3β,5α,6β-triol(1),(24R)-ergost-7,22-dien-3β,5α,6β-triol(2),ergost-24(28)-en-3β,5α,6β-triol(3),(24 S)-ergost-7(8)-en-3β,5α,6β-triol(4),23-demethylgorgost-7-en-3β,5α,6β-triol(5),ergosterol peroxide(6),cholesterol(7). Conclusion s All these compounds have the ergost-3β,5α,6β-tiol substructure segment except the common ergosterol peroxide and cholesterol.Preliminary bioactive experiment indicated that these compounds have the effect of antimicrobial activity.

MENG Li-yuan, LI Xiu-bao, ZHANG Wen, LI Ling, SUN Peng, TANG Hua, LIU Bao-shu, YI Yang-hua. Bioactive constituents from Sinularia sp[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 274-278.
Citation: MENG Li-yuan, LI Xiu-bao, ZHANG Wen, LI Ling, SUN Peng, TANG Hua, LIU Bao-shu, YI Yang-hua. Bioactive constituents from Sinularia sp[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 274-278.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return