Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel

Key words: 
• ginkgo biloba leaf extract /
• in-situ nasal gel /
• sorbefacients

Abstract: Objective To preparation of ginkgo biloba leaf in-situ nasal gel and exploration of the effect of sorbefacients on nasal mucosa Absorption. Methods Carbopol 934 and HPMC were used as gel matrix to prepare pH sensitive in-situ ginkgo biloba leaf nasal gel,whose viscosity,adhesion,and in vitro nasal mucosa Absorption were studied. Results The in-situ ginkgo biloba leaf gel can be best prepared with 0.8% of Carbopol 934 and 1.5% of HPMC as gel matrix.Three sorbefacients were studied.The sequence of their permeation rate were 1% of Azone > 1% of Twain-80 > 0.5% of Borneol.The drug Absorption rate increases as the Azone concentration increases,the it’s Absorption process fits Weibull equation. Conclusion The preparation technology of in-situ ginkgo biloba leaf nasal gel is viable.And Azone is the most effective sorbefacient for nasal mucosa Absorption.