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Volume 28 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 45-47

WANG Shu-dong, PAN Jing, FANG Li, XIA Shu-hui, SONG Bing-sheng. Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 45-47.
Citation: WANG Shu-dong, PAN Jing, FANG Li, XIA Shu-hui, SONG Bing-sheng. Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 45-47.
shu

Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC

  • Deptarment of Pharmaceuticals,Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China

  • Received Date: 2009-04-22
  • Rev Recd Date: 2009-10-16
  • Objective To establish a quantitative determination method for lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC. Methods The determination was carried out with a Hedera-ODS-3 C18 column(4.6 mm×250 mm,5 μm).The mobile phase consisted of acetonitrile-1%phosphoric acid solution(12:88),with pH adjusted to 3.0±0.1 by using triethylamine.Detecting wavelength was at 254 nm. Results The linear range for lidocaine hydrochloride and norfloxacine was both 0.025～0.100 mg/ml.The average recovery and RSD of norfloxacine were 98.84% and 1.72%,and those of lidocaine hydrochloride were 100.24% and 1.86%. Conclusion The method offers simple instrumental operation,good stability,and high accuracy for the determination of the chitosan hemostatic sponge.
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Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC

  • Deptarment of Pharmaceuticals,Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,China
  • Received Date: 2009-04-22
  • Rev Recd Date: 2009-10-16

Abstract: Objective To establish a quantitative determination method for lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC. Methods The determination was carried out with a Hedera-ODS-3 C18 column(4.6 mm×250 mm,5 μm).The mobile phase consisted of acetonitrile-1%phosphoric acid solution(12:88),with pH adjusted to 3.0±0.1 by using triethylamine.Detecting wavelength was at 254 nm. Results The linear range for lidocaine hydrochloride and norfloxacine was both 0.025～0.100 mg/ml.The average recovery and RSD of norfloxacine were 98.84% and 1.72%,and those of lidocaine hydrochloride were 100.24% and 1.86%. Conclusion The method offers simple instrumental operation,good stability,and high accuracy for the determination of the chitosan hemostatic sponge.

WANG Shu-dong, PAN Jing, FANG Li, XIA Shu-hui, SONG Bing-sheng. Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 45-47.
Citation: WANG Shu-dong, PAN Jing, FANG Li, XIA Shu-hui, SONG Bing-sheng. Determination of lidocaine hydrochloride and norfloxacine in chitosan hemostatic sponge by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 45-47.
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