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Volume 28 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 32-33,72

YANG Li-hong, LI Xiao-ong, Pan Xiao-dong, WANG Ming-shan, CHEN Bi-cheng, LIN Yong-tong. Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 32-33,72.
Citation: YANG Li-hong, LI Xiao-ong, Pan Xiao-dong, WANG Ming-shan, CHEN Bi-cheng, LIN Yong-tong. Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 32-33,72.
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Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients

  • 1.

    First Affiliated Hospital,Wenzhou medical college,a.Laboratory Diagnostic Center

  • 2.

    First Affiliated Hospital,Wenzhou medical college,b.Surgical Laboratory

  • 3.

    Wenzhou medical college,Wenzhou 325000,China

  • Received Date: 2009-12-10
  • Rev Recd Date: 2009-12-29
  • Objective To investigate the effect on peripheral blood parameters and erythropoietin(EPO) of renal transplantation patients with different treatment of new immunosuppressive agents. Methods According to different immunosuppressive regimens,recipients were divided into rapamycin(RAP) group(28 cases) and tacrolimus(FK506) group(44 cases).During follow-up of the recipients,peripheral blood parameters,reticulocyte parameters,serum EPO level and serum creatinine were measured and analyzed. Results RBC,WBC,PLT and HGB of RAP group were significantly lower than that of FK506 group(P<0.01).RAP group has higher level of EPO concentration(P<0.01),but RET and Cr are no significant different from FK506 group(P>0.05). Conclusion RAP based immunosuppression regimen has bone marrow depressive effect and obviously influences the peripheral blood parameters.High level EPO was compensatory response.
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通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients

  • 1. First Affiliated Hospital,Wenzhou medical college,a.Laboratory Diagnostic Center
  • 2. First Affiliated Hospital,Wenzhou medical college,b.Surgical Laboratory
  • 3. Wenzhou medical college,Wenzhou 325000,China
  • Received Date: 2009-12-10
  • Rev Recd Date: 2009-12-29

Abstract: Objective To investigate the effect on peripheral blood parameters and erythropoietin(EPO) of renal transplantation patients with different treatment of new immunosuppressive agents. Methods According to different immunosuppressive regimens,recipients were divided into rapamycin(RAP) group(28 cases) and tacrolimus(FK506) group(44 cases).During follow-up of the recipients,peripheral blood parameters,reticulocyte parameters,serum EPO level and serum creatinine were measured and analyzed. Results RBC,WBC,PLT and HGB of RAP group were significantly lower than that of FK506 group(P<0.01).RAP group has higher level of EPO concentration(P<0.01),but RET and Cr are no significant different from FK506 group(P>0.05). Conclusion RAP based immunosuppression regimen has bone marrow depressive effect and obviously influences the peripheral blood parameters.High level EPO was compensatory response.

YANG Li-hong, LI Xiao-ong, Pan Xiao-dong, WANG Ming-shan, CHEN Bi-cheng, LIN Yong-tong. Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 32-33,72.
Citation: YANG Li-hong, LI Xiao-ong, Pan Xiao-dong, WANG Ming-shan, CHEN Bi-cheng, LIN Yong-tong. Influence of two immunosuppression regimens on peripheral blood parameters and erythropoietin of kidney transplantation recipients[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 32-33,72.
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