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Volume 27 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 445-447

LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
Citation: LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
shu

An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-04-03
  • Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.
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An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-04-03

Abstract: Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.

LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
Citation: LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
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