Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(5): 367-369

GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
Citation: GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
shu

Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel

  • 1.

    Undergraduate of 2005, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, 305th Hospital of PLA, Beijing 100017, China

  • 3.

    Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China

  • Received Date: 2009-04-03
  • Objective :To prepare cetirizine hydrochloride gel and study its skin penetration in vitro. Methods : Cetirizine gel was prepared with carbopol 940 as base material.Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier.The cumulative permeation quantity of cetirizine was determined by HPLC. Results :The penetration equation of cetirizine gel was Q=110.03t+17.17(r=0.99). Conclusion :The penetration of cetirizine from the gel through the rat skin followed first-order kinetics.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2420) PDF downloads(576) Cited by()

Related
Proportional views

Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel

  • 1. Undergraduate of 2005, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, 305th Hospital of PLA, Beijing 100017, China
  • 3. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China
  • Received Date: 2009-04-03

Abstract: Objective :To prepare cetirizine hydrochloride gel and study its skin penetration in vitro. Methods : Cetirizine gel was prepared with carbopol 940 as base material.Using Franz diffusion cell and excised rat skin in vitro as transdermal barrier.The cumulative permeation quantity of cetirizine was determined by HPLC. Results :The penetration equation of cetirizine gel was Q=110.03t+17.17(r=0.99). Conclusion :The penetration of cetirizine from the gel through the rat skin followed first-order kinetics.

GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
Citation: GAO Xiang, ZHANG Chen-Xi, YANG Ming, LIU Ji-Yong. Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 367-369.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return