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Volume 27 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(3): 170-173

JIANG Guo-jun, ZHANG LI, LI Tie-jun, QIU Yan, LOU Yi-jia. Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 170-173.
Citation: JIANG Guo-jun, ZHANG LI, LI Tie-jun, QIU Yan, LOU Yi-jia. Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 170-173.
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Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein

  • 1.

    Department of Pharmacy, Zhejiang Xiaoshan Hospital;Hangzhou 311201, China

  • 2.

    School of Pharmacy, Secondary Military Medical University, Shanghai 200433, China

  • 3.

    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China

  • Received Date: 2008-06-03
  • Objective :To study the effects of expression of hypoxia inducible 1 alpha(HIF-1α) on U937 cell stimulated by oxidized low density lipoprotein(ox-LDL) and the influence of lovastatin. Methods :Foam cell formation was tested by oil red O-stain analysis,and expression of HIF-1α was measured by the method of Real-time PCR and Western blotting. Results :Foam cell was not formed by U937 cell without ox-LDL stimulating;U937 cell with ox-LDL stimulating for 24 h was transformed to foam cell.After treated with ox-LDL,the expression of HIF-1αwas markedly increased on U937 cells;with the combined treatment of lovastatin ox-LDL,the expression of HIF-1αwas significantly decreased,and this inhibitory effect was dose dependant. Conclusion :Lovasatin could inhibit both the expression of HIF-1αon U937 and the foam cell formation induced by ox-LDL.
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Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein

  • 1. Department of Pharmacy, Zhejiang Xiaoshan Hospital;Hangzhou 311201, China
  • 2. School of Pharmacy, Secondary Military Medical University, Shanghai 200433, China
  • 3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China
  • Received Date: 2008-06-03

Abstract: Objective :To study the effects of expression of hypoxia inducible 1 alpha(HIF-1α) on U937 cell stimulated by oxidized low density lipoprotein(ox-LDL) and the influence of lovastatin. Methods :Foam cell formation was tested by oil red O-stain analysis,and expression of HIF-1α was measured by the method of Real-time PCR and Western blotting. Results :Foam cell was not formed by U937 cell without ox-LDL stimulating;U937 cell with ox-LDL stimulating for 24 h was transformed to foam cell.After treated with ox-LDL,the expression of HIF-1αwas markedly increased on U937 cells;with the combined treatment of lovastatin ox-LDL,the expression of HIF-1αwas significantly decreased,and this inhibitory effect was dose dependant. Conclusion :Lovasatin could inhibit both the expression of HIF-1αon U937 and the foam cell formation induced by ox-LDL.

JIANG Guo-jun, ZHANG LI, LI Tie-jun, QIU Yan, LOU Yi-jia. Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 170-173.
Citation: JIANG Guo-jun, ZHANG LI, LI Tie-jun, QIU Yan, LOU Yi-jia. Effects of lovastatin on expression of hypoxia inducible factor 1 alpha on U937 cell induced by oxidized low density lipoprotein[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 170-173.
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