Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection

Key words: 
• HPLC /
• potassium sodium dehydroandrographolide succinate for injection /
• cefuroxime sodium /
• compatibility /
• stability

Abstract: Objective : To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with cefuroxime sodium injection in 0.9% sodium chloride injection. Methods : HPLC method was adopted.The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with Cefuroxime injection in 0.9% sodium chloride injection under the room temperature within 8 hours,and the appearance of the solution was observed and its pH value was determined. Results :No significant differences were found in terms of pH value,but the colour gradually deepens as time goes on.The relative percentage of cefuroxime sodium drops to below 95% after 5 h,and the degradation product peak area accounts for the total peak area percentage to surpass 1% after 4 h. Conclusions :The mixture of potassium sodium dehydroandrographolide succinate with cefuroxime sodium injection in 0.9% sodium chloride injection can be used in NS under room temperature,but must be injected during 4 hours.