Synthesis and antiplatelet aggregative activity of 6-[4-(substituted amino acetamido-phenyl)]-4,5-dihydro-3(2H)-pyridazinones

Key words: 
• chemical synthesis /
• pyridazinones /
• antiplatelet aggregative activity in vitro

Abstract: Objective: To synthesize new pyridazinone derivatives substituted by different amino groups. Methods: Eight target compounds were designed and synthesized by inletting different substituted amino groups connecting through the acetyl fragment.All of them were confirmed by ¹ H-NMR spectra.Born method was applied for preliminary pharmacological test in vitro. Results: All of the target compounds were reported for the first time.The results of preliminary pharmacological test showed that all the target compounds exhibited potent antiplatelet aggregative activity to a certain extent.Compounds（1）,（3）and（8）have better activeties;compound （3）showed a 6 times higher activity than that of MCI-154. Conclusion: Inletting different substituted amino groups can enhance the antiplatelet aggregation activity of the compounds.