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Volume 26 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (5): 357-358,361

PIAO Shu-juan, ZHANG Chun, JIANG Chun-xia, LIN Hou-Wen, CHEN Wan-sheng. Determination of lincomycin hydrochloride in lincomycin cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 357-358,361.
Citation: PIAO Shu-juan, ZHANG Chun, JIANG Chun-xia, LIN Hou-Wen, CHEN Wan-sheng. Determination of lincomycin hydrochloride in lincomycin cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 357-358,361.
shu

Determination of lincomycin hydrochloride in lincomycin cream by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China

  • Received Date: 2007-10-15
  • Objective:To establish high performance liquid chromatography method for determination the content of lincomycin hydrochloride in lincomycin cream.Methods:A YMC C18（250 mm×4.6 mm,5μm）column was used with the mobile phase of 0.05mol/L borax （adjust pH to 6.0 with phosphoric acid）-methanol （55:45）and UV wavelengh of 214 nm.Results:The calibration curve of lincomycin hydrochloride was line in the range of 10～30μg（r=0.999 7）.The average recovery was 98.74%（RSD= 2.06%,n=9）.The relative content of lincomycin hydrochloride in three batch of lincomycin cream was 96.21%,96.50% and 93.38%.Conclusion:This method is simple,quick,accurate and suitable for the quality control of lincomyein cream.
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Determination of lincomycin hydrochloride in lincomycin cream by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China
  • Received Date: 2007-10-15

Abstract: Objective:To establish high performance liquid chromatography method for determination the content of lincomycin hydrochloride in lincomycin cream.Methods:A YMC C18（250 mm×4.6 mm,5μm）column was used with the mobile phase of 0.05mol/L borax （adjust pH to 6.0 with phosphoric acid）-methanol （55:45）and UV wavelengh of 214 nm.Results:The calibration curve of lincomycin hydrochloride was line in the range of 10～30μg（r=0.999 7）.The average recovery was 98.74%（RSD= 2.06%,n=9）.The relative content of lincomycin hydrochloride in three batch of lincomycin cream was 96.21%,96.50% and 93.38%.Conclusion:This method is simple,quick,accurate and suitable for the quality control of lincomyein cream.

PIAO Shu-juan, ZHANG Chun, JIANG Chun-xia, LIN Hou-Wen, CHEN Wan-sheng. Determination of lincomycin hydrochloride in lincomycin cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 357-358,361.
Citation: PIAO Shu-juan, ZHANG Chun, JIANG Chun-xia, LIN Hou-Wen, CHEN Wan-sheng. Determination of lincomycin hydrochloride in lincomycin cream by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 357-358,361.
shu

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