Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 26 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (5): 354-356

FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
shu

Content determination of citrate in sodium citrate injection for catheter locking by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China

  • Received Date: 2007-09-27
  • Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column（250 mm×4.6 mm,5μm）,using MeOH:0.05 mol/L KH2PO4（adjusted to pH 2.5～2.8 by H3PO4）（5:95,v:v）as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5～6 mg/mL（r=0.999 9,n=5）.The average recovery was 98.79% （RSD=1.08%）.The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2484) PDF downloads(729) Cited by()

Related
Proportional views

Content determination of citrate in sodium citrate injection for catheter locking by HPLC

  • Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China
  • Received Date: 2007-09-27

Abstract: Objective:To establish a content determination method of citrate in sodium citrate injection for catheter locking. Methods:HPLC was used to determine citrate on Diamonsil C18 column（250 mm×4.6 mm,5μm）,using MeOH:0.05 mol/L KH2PO4（adjusted to pH 2.5～2.8 by H3PO4）（5:95,v:v）as a mobile phase with a flow rate at 1.0 mL/min and UV wavelengh of 210 nm.Results:The calibration curve of citrate was line in the range of 0.5～6 mg/mL（r=0.999 9,n=5）.The average recovery was 98.79% （RSD=1.08%）.The relative contents of citrate in three batch of citrate in sodium citrate injection for catheter locking were 100.51%,98.22% and 97.78%,respectively.Conclusion:This method was simple,rapid,accurate and suitable for the quality control of citrate.

FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
Citation: FAN Rong, ZHANG Chun, GUAN Hao-yue, PIAO Shu-juan. Content determination of citrate in sodium citrate injection for catheter locking by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2008, (5): 354-356.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return