Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 26 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2008  >  (1): 23-27,50

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
Citation: SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
shu

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

  • 1.

    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China

  • 2.

    Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China

  • 3.

    Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2007-08-28
  • Rev Recd Date: 2007-09-03
  • Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2312) PDF downloads(991) Cited by()

Related
Proportional views

Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice

  • 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • 2. Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, Shanghai 200433, China
  • 3. Department of Natural Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2007-08-28
  • Rev Recd Date: 2007-09-03

Abstract: Objective: To investigate the effects of Dehydrocavidine (YHL-DC) on carbon tetrachloride (CCl4) induced acute liver injury in mice. Methods: The mice were pre-treatment with YHL-DC prior to the administration of CCl4 and post-treatment with YHL-DC after the administration of CCl4, and the changes of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in these mice were examined respectively. Histopathology changes of liver were also observed under both light and electron microscope. Results: Pre-treatment and post-treatment with YHL-DC significantly prevented increase in serum enzymatic activities of ALT, AST and TBIL in a dose-dependent manner. Hepatocyte degeneration and necrosis, infiltration of inflammatory cells and destruction of hepatocyte ultrastructure appeared in carbon tetrachloride induced acute injured liver in mice, while extenuations were observed in both pre-and post-treatment groups administered with YHL-DC. Conclusion: The results suggest that YHL-DC has a potent hepatoprotective action on CCl4 induced acute liver injury in mice.

SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
Citation: SUN Ning-ling, WANG Tao, YUAN Ben-li, LI Hui-liang, LU Guo-cai, ZHANG Wei-dong, ZHANG Chuan, YUAN Bo-jun. Protective effects of dehydrocavidine on carbon tetrachloride induced acute liver injury in mice[J]. Journal of Pharmaceutical Practice and Service, 2008, (1): 23-27,50.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return