Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro

HE Quan-shan; YANG Chang-yun; CHEN Wei-zhong; YANG Xiang-yue; RONG Jiang-kai

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Volume 25 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2007 > (5): 303-306

HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.

Citation:

HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306.

Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro

1.
Department of Pharmacy, Fuzhou General Hospital, Fuzhou 350025, China
2.
Department of Pharmacy, No.180 Hospital of PLA Quanzhou 362000, china
3.
Shool of pharmacy, Second Military Medical University Shanghai 200433, china

Received Date: 2007-07-24

Abstract

Objective :To synthesize metallic salts of norfloxacin(NFLO) and evaluate their bacteriaostatic activities in vitro. Methods : The compounds were syntherized from the starting material norfloxacin and metallic salts.The bateriostatic activities of these new compounds were tested. Results : Five new compounds(NFLO-Ag,,NFLO-Zn,NFLO-Ce,NFLO-Co,NFLO-Bi) were produced and their primary quality criteria were established. Conclusions : The bateriostatic tests showed that these new compounds exhibit more potent antimicrobial activities than sliver sulfadiazine against Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa.
- Silver Norfloxacin,
- Zinc Norfloxacin,
- Cerous Norfloxacin,
- Chloriole Norfloxacin,
- Bismuth Norfloxacin,
- preparation,
- synthesis bacteriostatic activity.
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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