Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 25 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 290-291

GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
Citation: GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
shu

Determination of the dissociation constant and partition coefficient of mesylate delavirdine

  • 1.

    School of Pharmacy, Jilin University, Changchun 130021, China;School of Life Science, Jilin University, Changchun 130021, China

  • 2.

    School of Life Science, Jilin University, Changchun 130021, China

  • Received Date: 2007-04-09
  • Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2262) PDF downloads(50) Cited by()

Related
Proportional views

Determination of the dissociation constant and partition coefficient of mesylate delavirdine

  • 1. School of Pharmacy, Jilin University, Changchun 130021, China;School of Life Science, Jilin University, Changchun 130021, China
  • 2. School of Life Science, Jilin University, Changchun 130021, China
  • Received Date: 2007-04-09

Abstract: Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.

GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
Citation: GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return