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Volume 20 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2002  >  (4): 215-220

LI Yu-mei, ZHU Xiao-mei, ZHANG Cheng, WEI Hong-chang, ZENG Zao-lin, . The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2002, (4): 215-220.
Citation: LI Yu-mei, ZHU Xiao-mei, ZHANG Cheng, WEI Hong-chang, ZENG Zao-lin, . The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2002, (4): 215-220.
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The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits

  • Shanghai University of Traditional Chinese Medicine, Department of Patholog, Shanghai 200032, China

  • Received Date: 2001-12-27
  • OBJECTIVE In order to investigate the mechanism of the action of Da-cheng-qi-decoction (DD) in treating acute pulmonary edema, Rabbit model of experimental pulmonary edema was made with injecting oleic acid (group B), and then treated with DD (group C). Randomly 10 cases of normal rabbit without any treatment were served as the normal control group (group A). RESULT:In group B, the important pathological changes are interstitial and intra-alveolar edema, hemorrhage, hyaline thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina. DD show a effection of improving above pathological changes, promoting growth of pneumocyte espectialy pneumocyte Ⅱ, reducing multi-organs injury. These findings indicate that it may be its mainly mechanism in treating with acute pulmonary edema by eliminating exudation, enhancing the growth of pneu-mocyte Ⅱ, adjusting the balance of ventilation-perfusion, protecting organs from injury and so on.
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The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits

  • Shanghai University of Traditional Chinese Medicine, Department of Patholog, Shanghai 200032, China
  • Received Date: 2001-12-27

Abstract: OBJECTIVE In order to investigate the mechanism of the action of Da-cheng-qi-decoction (DD) in treating acute pulmonary edema, Rabbit model of experimental pulmonary edema was made with injecting oleic acid (group B), and then treated with DD (group C). Randomly 10 cases of normal rabbit without any treatment were served as the normal control group (group A). RESULT:In group B, the important pathological changes are interstitial and intra-alveolar edema, hemorrhage, hyaline thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina. DD show a effection of improving above pathological changes, promoting growth of pneumocyte espectialy pneumocyte Ⅱ, reducing multi-organs injury. These findings indicate that it may be its mainly mechanism in treating with acute pulmonary edema by eliminating exudation, enhancing the growth of pneu-mocyte Ⅱ, adjusting the balance of ventilation-perfusion, protecting organs from injury and so on.

LI Yu-mei, ZHU Xiao-mei, ZHANG Cheng, WEI Hong-chang, ZENG Zao-lin, . The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2002, (4): 215-220.
Citation: LI Yu-mei, ZHU Xiao-mei, ZHANG Cheng, WEI Hong-chang, ZENG Zao-lin, . The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2002, (4): 215-220.
shu

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